Counterfactual Risk Minimization: Learning from Logged Bandit Feedback

We develop a learning principle and an efficient algorithm for batch learning from logged bandit feedback. This learning setting is ubiquitous in online systems (e.g., ad placement, web search, recommendation), where an algorithm makes a prediction (e.g., ad ranking) for a given input (e.g., query) and observes bandit feedback (e.g., user clicks on presented ads). We first address the counterfactual nature of the learning problem through propensity scoring. Next, we prove generalization error bounds that account for the variance of the propensity-weighted empirical risk estimator. These constructive bounds give rise to the Counterfactual Risk Minimization (CRM) principle. We show how CRM can be used to derive a new learning method -- called Policy Optimizer for Exponential Models (POEM) -- for learning stochastic linear rules for structured output prediction. We present a decomposition of the POEM objective that enables efficient stochastic gradient optimization. POEM is evaluated on several multi-label classification problems showing substantially improved robustness and generalization performance compared to the state-of-the-art.Comment: 10 page

Tips for Transitional Jobs Programs Serving People Experiencing Homelessness

This brief offers recommendations for employment programs using the TJ model to serve jobseekers who are experiencing or at risk of homelessness. These recommendations reflect the most relevant research findings as well as the experiences of expert TJ practitioners

Polarization restricts hepatitis C virus entry into HepG2 hepatoma cells

The primary reservoir for hepatitis C virus (HCV) replication is believed to be hepatocytes, which are highly polarized with tight junctions (TJ) separating their basolateral and apical domains. HepG2 cells develop polarity over time, resulting in the formation and remodeling of bile canalicular (BC) structures. HepG2 cells expressing CD81 provide a model system to study the effects of hepatic polarity on HCV infection. We found an inverse association between HepG2-CD81 polarization and HCV pseudoparticle entry. As HepG2 cells polarize, discrete pools of claudin-1 (CLDN1) at the TJ and basal/lateral membranes develop, consistent with the pattern of receptor staining observed in liver tissue. The TJ and nonjunctional pools of CLDN1 show an altered association with CD81 and localization in response to the PKA antagonist Rp-8-Br-cyclic AMPs (cAMPs). Rp-8-Br-cAMPs reduced CLDN1 expression at the basal membrane and inhibited HCV infection, supporting a model where the nonjunctional pools of CLDN1 have a role in HCV entry. Treatment of HepG2 cells with proinflammatory cytokines, tumor necrosis factor alpha and gamma interferon, perturbed TJ integrity but had minimal effect(s) on cellular polarity and HCV infection, suggesting that TJ integrity does not limit HCV entry into polarized HepG2 cells. In contrast, activation of PKC with phorbol ester reduced TJ integrity, ablated HepG2 polarity, and stimulated HCV entry. Overall, these data show that complex hepatocyte-like polarity alters CLDN1 localization and limits HCV entry, suggesting that agents which disrupt hepatocyte polarity may promote HCV infection and transmission within the liver

The Transitional Jobs Reentry Demonstration: Advancing the Field of Transitional Jobs

The field of Transitional Jobs (TJ) is committed to providing employment opportunities to people throughout our nation who have struggled to find or keep a job. The National Transitional Jobs Network is committed to helping practitioners implement tested best practices to improve TJ program outcomes

Electron Bernstein waves emission in the TJ-II Stellarator

Taking advantage of the electron Bernstein waves heating (EBWH) system of the TJ-II stellarator, an electron Bernstein emission (EBE) diagnostic was installed. Its purpose is to investigate the B-X-O radiation properties in the zone where optimum theoretical EBW coupling is predicted. An internal movable mirror shared by both systems allows us to collect the EBE radiation along the same line of sight that is used for EBW heating. The theoretical EBE has been calculated for different orientations of the internal mirror using the TRUBA code as ray tracer. A comparison with experimental data obtained in NBI discharges is carried out. The results provide a valuable information regarding the experimental O-X mode conversion window expected in the EBW heating experiments. Furthermore, the characterization of the radiation polarization shows evidence of the underlying B-X-O conversion process.Comment: 21 pages, 14 figure

Effective Job Development Strategies for Working with the Hardest to Employ

Effective job development -- creating opportunity for subsidized employees to move into the unsubsidized labor market -- is integral to the goals and successful outcomes of the Transitional Jobs (TJ) strategy. It is also one of the most challenging aspects of TJ program delivery, especially during times of high unemployment

On kinetic energy stabilized superconductivity in cuprates

The possibility of kinetic energy driven superconductivity in cuprates as was recently found in the $tJ$ model is discussed. We argue that the violation of the virial theorem implied by this result is serious and means that the description of superconductivity within the $tJ$ model is pathological.Comment: 3 pages, v2 includes additional reference

Funding Transitional Jobs Programs: Identifying Sources and Developing Proposals

Securing adequate funding to operate a Transitional Jobs (TJ) program can be challenging This brief presents some basic tips for finding funding sources and developing proposals that may be helpful for startups and seasoned TJ providers alike as they pursue the financial support necessary for quality programs to help their participants find and keep employment