5,192 research outputs found
Towards hardware acceleration of neuroevolution for multimedia processing applications on mobile devices
This paper addresses the problem of accelerating large artificial neural networks (ANN), whose topology and weights can evolve via the use of a genetic algorithm. The proposed digital hardware architecture is capable of processing any evolved network topology, whilst at the same time providing a good trade off between throughput, area and power consumption. The latter is vital for a longer battery life on mobile devices. The architecture uses multiple parallel arithmetic units in each processing element (PE). Memory partitioning and data caching are used to minimise the effects of PE pipeline stalling. A first order minimax polynomial approximation scheme, tuned via a genetic algorithm, is used for the activation function generator. Efficient arithmetic circuitry, which leverages modified Booth recoding, column compressors and carry save adders, is adopted throughout the design
Protein alignment HW/SW optimizations
Biosequence alignment recently received an amazing support from both commodity and dedicated hardware platforms. The limitless requirements of this application motivate the search for improved implementations to boost processing time and capabilities. We propose an unprecedented hardware improvement to the classic Smith-Waterman (S-W) algorithm based on a twofold approach: i) an on-the-fly gap-open/gap-extension selection that reduces the hardware implementation complexity; ii) a pre-selection filter that uses reduced amino-acid alphabets to screen out not-significant sequences and to shorten the S-Witerations on huge reference databases.We demonstrated the improvements w.r.t. a classic approach both from the point of view of algorithm efficiency and of HW performance (FPGA and ASIC post-synthesis analysis)
Effective network grid synthesis and optimization for high performance very large scale integration system design
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An efficient hardware architecture for a neural network activation function generator
This paper proposes an efficient hardware architecture for a function generator suitable for an artificial neural network (ANN). A spline-based approximation function is designed that provides a good trade-off between accuracy and silicon area, whilst also being inherently scalable and adaptable for numerous activation functions. This has been achieved by using a minimax polynomial and through optimal placement of the approximating polynomials based on the results of a genetic algorithm. The approximation error of the proposed method compares favourably to all related research in this field. Efficient hardware multiplication circuitry is used in the implementation, which reduces the area overhead and increases the throughput
Automated Circuit Approximation Method Driven by Data Distribution
We propose an application-tailored data-driven fully automated method for
functional approximation of combinational circuits. We demonstrate how an
application-level error metric such as the classification accuracy can be
translated to a component-level error metric needed for an efficient and fast
search in the space of approximate low-level components that are used in the
application. This is possible by employing a weighted mean error distance
(WMED) metric for steering the circuit approximation process which is conducted
by means of genetic programming. WMED introduces a set of weights (calculated
from the data distribution measured on a selected signal in a given
application) determining the importance of each input vector for the
approximation process. The method is evaluated using synthetic benchmarks and
application-specific approximate MAC (multiply-and-accumulate) units that are
designed to provide the best trade-offs between the classification accuracy and
power consumption of two image classifiers based on neural networks.Comment: Accepted for publication at Design, Automation and Test in Europe
(DATE 2019). Florence, Ital
Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2
Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is great interest in the therapeutic benefit for ACE2 overexpression in the heart. However, the role of ACE2 in the regulation of cardiac structure and function, as well as maintenance of systemic blood pressure, remains poorly understood. In cell culture, ACE2 overexpression led to markedly increased myocyte volume, assessed in primary rabbit myocytes. To assess ACE2 function in vivo, we used a recombinant adeno-associated virus 6 delivery system to provide 11-week overexpression of ACE2 in the myocardium of stroke-prone spontaneously hypertensive rats. ACE2, as well as the ACE inhibitor enalapril, significantly reduced systolic blood pressure. However, in the heart, ACE2 overexpression resulted in cardiac fibrosis, as assessed by histological analysis with concomitant deficits in ejection fraction and fractional shortening measured by echocardiography. Furthermore, global gene expression profiling demonstrated the activation of profibrotic pathways in the heart mediated by ACE2 gene delivery. This study demonstrates that sustained overexpression of ACE2 in the heart in vivo leads to the onset of severe fibrosis
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