Collaborative Artificial Intelligence Algorithms for Medical Imaging Applications

In this dissertation, we propose novel machine learning algorithms for high-risk medical imaging applications. Specifically, we tackle current challenges in radiology screening process and introduce cutting-edge methods for image-based diagnosis, detection and segmentation. We incorporate expert knowledge through eye-tracking, making the whole process human-centered. This dissertation contributes to machine learning, computer vision, and medical imaging research by: 1) introducing a mathematical formulation of radiologists level of attention, and sparsifying their gaze data for a better extraction and comparison of search patterns. 2) proposing novel, local and global, image analysis algorithms. Imaging based diagnosis and pattern analysis are high-risk Artificial Intelligence applications. A standard radiology screening procedure includes detection, diagnosis and measurement (often done with segmentation) of abnormalities. We hypothesize that having a true collaboration is essential for a better control mechanism, in such applications. In this regard, we propose to form a collaboration medium between radiologists and machine learning algorithms through eye-tracking. Further, we build a generic platform consisting of novel machine learning algorithms for each of these tasks. Our collaborative algorithm utilizes eye tracking and includes an attention model and gaze-pattern analysis, based on data clustering and graph sparsification. Then, we present a semi-supervised multi-task network for local analysis of image in radiologists\u27 ROIs, extracted in the previous step. To address missing tumors and analyze regions that are completely missed by radiologists during screening, we introduce a detection framework, S4ND: Single Shot Single Scale Lung Nodule Detection. Our proposed detection algorithm is specifically designed to handle tiny abnormalities in lungs, which are easy to miss by radiologists. Finally, we introduce a novel projective adversarial framework, PAN: Projective Adversarial Network for Medical Image Segmentation, for segmenting complex 3D structures/organs, which can be beneficial in the screening process by guiding radiologists search areas through segmentation of desired structure/organ

Online Object Tracking with Proposal Selection

Tracking-by-detection approaches are some of the most successful object trackers in recent years. Their success is largely determined by the detector model they learn initially and then update over time. However, under challenging conditions where an object can undergo transformations, e.g., severe rotation, these methods are found to be lacking. In this paper, we address this problem by formulating it as a proposal selection task and making two contributions. The first one is introducing novel proposals estimated from the geometric transformations undergone by the object, and building a rich candidate set for predicting the object location. The second one is devising a novel selection strategy using multiple cues, i.e., detection score and edgeness score computed from state-of-the-art object edges and motion boundaries. We extensively evaluate our approach on the visual object tracking 2014 challenge and online tracking benchmark datasets, and show the best performance.Comment: ICCV 201

Track, then Decide: Category-Agnostic Vision-based Multi-Object Tracking

The most common paradigm for vision-based multi-object tracking is tracking-by-detection, due to the availability of reliable detectors for several important object categories such as cars and pedestrians. However, future mobile systems will need a capability to cope with rich human-made environments, in which obtaining detectors for every possible object category would be infeasible. In this paper, we propose a model-free multi-object tracking approach that uses a category-agnostic image segmentation method to track objects. We present an efficient segmentation mask-based tracker which associates pixel-precise masks reported by the segmentation. Our approach can utilize semantic information whenever it is available for classifying objects at the track level, while retaining the capability to track generic unknown objects in the absence of such information. We demonstrate experimentally that our approach achieves performance comparable to state-of-the-art tracking-by-detection methods for popular object categories such as cars and pedestrians. Additionally, we show that the proposed method can discover and robustly track a large variety of other objects.Comment: ICRA'18 submissio

Action Recognition in Videos: from Motion Capture Labs to the Web

This paper presents a survey of human action recognition approaches based on visual data recorded from a single video camera. We propose an organizing framework which puts in evidence the evolution of the area, with techniques moving from heavily constrained motion capture scenarios towards more challenging, realistic, "in the wild" videos. The proposed organization is based on the representation used as input for the recognition task, emphasizing the hypothesis assumed and thus, the constraints imposed on the type of video that each technique is able to address. Expliciting the hypothesis and constraints makes the framework particularly useful to select a method, given an application. Another advantage of the proposed organization is that it allows categorizing newest approaches seamlessly with traditional ones, while providing an insightful perspective of the evolution of the action recognition task up to now. That perspective is the basis for the discussion in the end of the paper, where we also present the main open issues in the area.Comment: Preprint submitted to CVIU, survey paper, 46 pages, 2 figures, 4 table

A Survey on Deep Learning in Medical Image Analysis

Deep learning algorithms, in particular convolutional networks, have rapidly become a methodology of choice for analyzing medical images. This paper reviews the major deep learning concepts pertinent to medical image analysis and summarizes over 300 contributions to the field, most of which appeared in the last year. We survey the use of deep learning for image classification, object detection, segmentation, registration, and other tasks and provide concise overviews of studies per application area. Open challenges and directions for future research are discussed.Comment: Revised survey includes expanded discussion section and reworked introductory section on common deep architectures. Added missed papers from before Feb 1st 201