11,151 research outputs found
A Design Science Research Approach to Smart and Collaborative Urban Supply Networks
Urban supply networks are facing increasing demands and challenges and thus constitute a relevant field for research and practical development. Supply chain management holds enormous potential and relevance for society and everyday life as the flow of goods and information are important economic functions. Being a heterogeneous field, the literature base of supply chain management research is difficult to manage and navigate. Disruptive digital technologies and the implementation of cross-network information analysis and sharing drive the need for new organisational and technological approaches. Practical issues are manifold and include mega trends such as digital transformation, urbanisation, and environmental awareness.
A promising approach to solving these problems is the realisation of smart and collaborative supply networks. The growth of artificial intelligence applications in recent years has led to a wide range of applications in a variety of domains. However, the potential of artificial intelligence utilisation in supply chain management has not yet been fully exploited. Similarly, value creation increasingly takes place in networked value creation cycles that have become continuously more collaborative, complex, and dynamic as interactions in business processes involving information technologies have become more intense.
Following a design science research approach this cumulative thesis comprises the development and discussion of four artefacts for the analysis and advancement of smart and collaborative urban supply networks. This thesis aims to highlight the potential of artificial intelligence-based supply networks, to advance data-driven inter-organisational collaboration, and to improve last mile supply network sustainability. Based on thorough machine learning and systematic literature reviews, reference and system dynamics modelling, simulation, and qualitative empirical research, the artefacts provide a valuable contribution to research and practice
Strategies for Early Learners
Welcome to learning about how to effectively plan curriculum for young children. This textbook will address: • Developing curriculum through the planning cycle • Theories that inform what we know about how children learn and the best ways for teachers to support learning • The three components of developmentally appropriate practice • Importance and value of play and intentional teaching • Different models of curriculum • Process of lesson planning (documenting planned experiences for children) • Physical, temporal, and social environments that set the stage for children’s learning • Appropriate guidance techniques to support children’s behaviors as the self-regulation abilities mature. • Planning for preschool-aged children in specific domains including o Physical development o Language and literacy o Math o Science o Creative (the visual and performing arts) o Diversity (social science and history) o Health and safety • Making children’s learning visible through documentation and assessmenthttps://scholar.utc.edu/open-textbooks/1001/thumbnail.jp
Estudo da remodelagem reversa miocárdica através da análise proteómica do miocárdio e do líquido pericárdico
Valve replacement remains as the standard therapeutic option for aortic
stenosis patients, aiming at abolishing pressure overload and triggering
myocardial reverse remodeling. However, despite the instant hemodynamic
benefit, not all patients show complete regression of myocardial hypertrophy,
being at higher risk for adverse outcomes, such as heart failure. The current
comprehension of the biological mechanisms underlying an incomplete reverse
remodeling is far from complete. Furthermore, definitive prognostic tools and
ancillary therapies to improve the outcome of the patients undergoing valve
replacement are missing. To help abridge these gaps, a combined myocardial
(phospho)proteomics and pericardial fluid proteomics approach was followed,
taking advantage of human biopsies and pericardial fluid collected during
surgery and whose origin anticipated a wealth of molecular information
contained therein.
From over 1800 and 750 proteins identified, respectively, in the myocardium
and in the pericardial fluid of aortic stenosis patients, a total of 90 dysregulated
proteins were detected. Gene annotation and pathway enrichment analyses,
together with discriminant analysis, are compatible with a scenario of increased
pro-hypertrophic gene expression and protein synthesis, defective ubiquitinproteasome system activity, proclivity to cell death (potentially fed by
complement activity and other extrinsic factors, such as death receptor
activators), acute-phase response, immune system activation and fibrosis.
Specific validation of some targets through immunoblot techniques and
correlation with clinical data pointed to complement C3 β chain, Muscle Ring
Finger protein 1 (MuRF1) and the dual-specificity Tyr-phosphorylation
regulated kinase 1A (DYRK1A) as potential markers of an incomplete
response. In addition, kinase prediction from phosphoproteome data suggests
that the modulation of casein kinase 2, the family of IκB kinases, glycogen
synthase kinase 3 and DYRK1A may help improve the outcome of patients
undergoing valve replacement. Particularly, functional studies with DYRK1A+/-
cardiomyocytes show that this kinase may be an important target to treat
cardiac dysfunction, provided that mutant cells presented a different response
to stretch and reduced ability to develop force (active tension).
This study opens many avenues in post-aortic valve replacement reverse
remodeling research. In the future, gain-of-function and/or loss-of-function
studies with isolated cardiomyocytes or with animal models of aortic bandingdebanding will help disclose the efficacy of targeting the surrogate therapeutic
targets. Besides, clinical studies in larger cohorts will bring definitive proof of
complement C3, MuRF1 and DYRK1A prognostic value.A substituição da válvula aórtica continua a ser a opção terapêutica de
referência para doentes com estenose aórtica e visa a eliminação da
sobrecarga de pressão, desencadeando a remodelagem reversa miocárdica.
Contudo, apesar do benefício hemodinâmico imediato, nem todos os pacientes
apresentam regressão completa da hipertrofia do miocárdio, ficando com maior
risco de eventos adversos, como a insuficiência cardíaca. Atualmente, os
mecanismos biológicos subjacentes a uma remodelagem reversa incompleta
ainda não são claros. Além disso, não dispomos de ferramentas de
prognóstico definitivos nem de terapias auxiliares para melhorar a condição
dos pacientes indicados para substituição da válvula. Para ajudar a resolver
estas lacunas, uma abordagem combinada de (fosfo)proteómica e proteómica
para a caracterização, respetivamente, do miocárdio e do líquido pericárdico
foi seguida, tomando partido de biópsias e líquidos pericárdicos recolhidos em
ambiente cirúrgico.
Das mais de 1800 e 750 proteínas identificadas, respetivamente, no miocárdio
e no líquido pericárdico dos pacientes com estenose aórtica, um total de 90
proteínas desreguladas foram detetadas. As análises de anotação de genes,
de enriquecimento de vias celulares e discriminativa corroboram um cenário de
aumento da expressão de genes pro-hipertróficos e de síntese proteica, um
sistema ubiquitina-proteassoma ineficiente, uma tendência para morte celular
(potencialmente acelerada pela atividade do complemento e por outros fatores
extrínsecos que ativam death receptors), com ativação da resposta de fase
aguda e do sistema imune, assim como da fibrose.
A validação de alguns alvos específicos através de immunoblot e correlação
com dados clínicos apontou para a cadeia β do complemento C3, a Muscle
Ring Finger protein 1 (MuRF1) e a dual-specificity Tyr-phosphoylation
regulated kinase 1A (DYRK1A) como potenciais marcadores de uma resposta
incompleta. Por outro lado, a predição de cinases a partir do fosfoproteoma,
sugere que a modulação da caseína cinase 2, a família de cinases do IκB, a
glicogénio sintase cinase 3 e da DYRK1A pode ajudar a melhorar a condição
dos pacientes indicados para intervenção. Em particular, a avaliação funcional
de cardiomiócitos DYRK1A+/- mostraram que esta cinase pode ser um alvo
importante para tratar a disfunção cardíaca, uma vez que os miócitos mutantes
responderam de forma diferente ao estiramento e mostraram uma menor
capacidade para desenvolver força (tensão ativa).
Este estudo levanta várias hipóteses na investigação da remodelagem reversa.
No futuro, estudos de ganho e/ou perda de função realizados em
cardiomiócitos isolados ou em modelos animais de banding-debanding da
aorta ajudarão a testar a eficácia de modular os potenciais alvos terapêuticos
encontrados. Além disso, estudos clínicos em coortes de maior dimensão
trarão conclusões definitivas quanto ao valor de prognóstico do complemento
C3, MuRF1 e DYRK1A.Programa Doutoral em Biomedicin
Omics measures of ageing and disease susceptibility
While genomics has been a major field of study for decades due to relatively inexpensive genotyping arrays, the recent advancement of technology has also allowed the measure and study of various “omics”. There are now numerous methods and platforms available that allow high throughput and high dimensional quantification of many types of biological molecules. Traditional genomics and transcriptomics are now joined by proteomics, metabolomics, glycomics, lipidomics and epigenomics.
I was lucky to have access to a unique resource in the Orkney Complex Disease Study (ORCADES), a cohort of individuals from the Orkney Islands that are extremely deeply annotated. Approximately 1000 individuals in ORCADES have genomics, proteomics, lipidomics, glycomics, metabolomics, epigenomics, clinical risk factors and disease phenotypes, as well as body composition measurements from whole body scans. In addition to these cross-sectional omics and health related measures, these individuals also have linked electronic health records (EHR) available, allowing the assessment of the effect of these omics measures on incident disease over a ~10-year follow up period. In this thesis I use this phenotype rich resource to investigate the relationship between multiple types of omics measures and both ageing and health outcomes.
First, I used the ORCADES data to construct measures of biological age (BA). The idea that there is an underlying rate at which the body deteriorates with age that varies between individuals of the same chronological age, this biological age, would be more indicative of health status, functional capacity and risk of age-related diseases than chronological age. Previous models estimating BA (ageing clocks) have predominantly been built using a single type of omics assay and comparison between different omics ageing clocks has been limited. I performed the most exhaustive comparison of different omics ageing clocks yet, with eleven clocks spanning nine different omics assays. I show that different omics clocks overlap in the information they provide about age, that some omics clocks track more generalised ageing while others track specific disease risk factors and that omics ageing clocks are prognostic of incident disease over and above chronological age.
Second, I assessed whether individually or in multivariable models, omics measures are associated with health-related risk factors or prognostic of incident disease over 10 years post-assessment. I show that 2,686 single omics biomarkers are associated with 10 risk factors and 44 subsequent incident diseases. I also show that models built using multiple biomarkers from whole body scans, metabolomics, proteomics and clinical risk factors are prognostic of subsequent diabetes mellitus and that clinical risk factors are prognostic of incident hypertensive disorders, obesity, ischaemic heart disease and Framingham risk score.
Third, I investigated the genetic architecture of a subset of the proteomics measures available in ORCADES, specifically 184 cardiovascular-related proteins. Combining genome-wide association (GWAS) summary statistics from ORCADES and 17 other cohorts from the SCALLOP Consortium, giving a maximum sample size of 26,494 individuals, I performed 184 genome-wide association meta-analyses (GWAMAs) on the levels of these proteins circulating in plasma. I discovered 592 independent significant loci associated with the levels of at least one protein. I found that between 8-37% of these significant loci colocalise with known expression quantitative trait loci (eQTL). I also find evidence of causal associations between 11 plasma protein levels and disease susceptibility using Mendelian randomisation, highlighting potential candidate drug targets
Physical phenomena controlling quiescent flame spread in porous wildland fuel beds
Despite well-developed solid surface flame spread theories, we still lack a coherent theory to describe flame spread through porous wildland fuel beds. This porosity results in additional complexity, reducing the thermal conductivity of the fuel bed, but allowing in-bed radiative and convective heat transfer to occur. While previous studies have explored the effect of fuel bed structure on the overall fire behaviour, there remains a need for further investigation of the effect of fuel structure on the underlying physical phenomena controlling flame spread. Through an extensive series of laboratory-based experiments, this thesis provides detailed, physics-based insights for quiescent flame spread through natural porous beds, across a range of structural conditions.
Measurements are presented for fuel beds representative of natural field conditions within an area of the fire-prone New Jersey Pinelands National Reserve, which compliment a related series of field experiments conducted as part of a wider research project. Additional systematic investigation across a wider range of fuel conditions identified independent effects of fuel loading and bulk density on the spread rate, flame height and heat release rate. However, neither fuel loading nor bulk density alone provided adequate prediction of the resulting fire behaviour. Drawing on existing structural descriptors (for both natural and engineered fuel beds) an alternative parameter ασδ was proposed. This parameter (incorporating the fuel bed porosity (α), fuel element surface-to-volume ratio (σ), and the fuel bed height (δ)) was strongly correlated with the spread rate.
One effect of the fuel bed structure is to influence the heat transfer mechanisms both above and within the porous fuel bed. Existing descriptions of radiation transport through porous fuel beds are often predicated on the assumption of an isotropic fuel bed. However, given their preferential angle of inclination, the pine needle beds in this study may not exhibit isotropic behaviour.
Regardless, for the structural conditions investigated, horizontal heat transfer through the fuel bed was identified as the dominant heating mechanism within this quiescent flame spread scenario. However, the significance of heat transfer contributions from the above-bed flame generally increased with increasing ασδ value of the fuel bed. Using direct measurements of the heat flux magnitude and effective heating distance, close agreement was observed between experimentally observed spread rates and a simple thermal model considering only radiative heat transfer through the fuel bed, particularly at lower values of ασδ. Over-predictions occurred at higher ασδ values, or where other heat transfer terms were incorporated, which may highlight the need to include additional heat loss terms.
A significant effect of fuel structure on the primary flow regimes, both within and above these porous fuel beds, was also observed, with important implications for the heat transfer and oxygen supply within the fuel bed. Independent effects of fuel loading and bulk density on both the buoyant and buoyancy-driven entrainment flow were observed, with a complex feedback cycle occurring between Heat Release Rate (HRR) and combustion behaviour. Generally, increases in fuel loading resulted in increased HRR, and therefore increased buoyant flow velocity, along with an increase in the velocity of flow entrained towards the combustion region.
The complex effects of fuel structure in both the flaming and smouldering combustion phases may necessitate modifications to other common modelling approaches. The widely used Rothermel model under-predicted spread rate for higher bulk density and lower ασδ fuel beds. As previously suggested, an over-sensitivity to fuel bed height was observed, with experimental comparison indicating an under-prediction of reaction intensity at lower fuel heights. These findings have important implications particularly given the continuing widespread use of the Rothermel model, which continues to underpin elements of the BehavePlus fire modelling system and the US National Fire Danger Rating System.
The physical insights, and modelling approaches, developed for this low-intensity, quiescent flame spread scenario, are applicable to common prescribed fire activities. It is hoped that this work (alongside complimentary laboratory and field experiments conducted by various authors as part of a wider multi-agency project (SERDP-RC2641)) will contribute to the emerging field of prescribed fire science, and help to address the pressing need for further development of fire prediction and modelling tools
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Building Together: Problem Solving for Sustainability Consciousness
BUILDING TOGETHER:
PROBLEM SOLVING FOR SUSTAINABILITY CONSCIOUSNESS
FEBRUARY 2022
PAUL M. BOCKO, B.A., UNIVERSITY OF NEW HAMPSHIRE
M.S., ANTIOCH UNIVERSITY NEW ENGLAND
M.Ed. ANITOCH UNIVERSITY NEW ENGLAND
Ph.D., UNIVERSITY OF MASSACHUSETTS AMHERST
Directed by: Professor Linda Griffin
This case study examined the relationship of problem-based learning (PBL) and sustainability education in a combined fifth and sixth grade classroom in the northeast U.S. Research questions focused on PBL instructional strategies that promote sustainability education, skills and understandings promoted by PBL, and the extent that PBL affects students’ sustainability consciousness. One teacher and eleven students participated. Problem-posing, reconstructionist, and sociocultural theories framed the study. Relevant themes were identified in a review of sustainability consciousness (SC) and PreK-12 PBL research reports. The themes revealed that SC is a growing framework with which to assess sustainability education and PBL research has strong links with sustainability education learning outcomes. Survey, interview, artifact, and observational data were analyzed to understand the fifth and sixth grade class as a case study in sustainability education. Results include a learning environment that emphasizes a pedagogy of sustainable thinking, student exhibition of sustainability education skills and understandings, and a lack of quantitative evidence of growth in students’ SC contrasted
with evidence of SC in students’ written work. Findings affirmed prior PBL research focused on group collaboration, interdependency, and reflection. The study identified the need to study PBL in real-world contexts rather than only through problem scenarios. Contributions to knowledge include adding to PBL research literature, highlighting the importance of learning experiences designed to meet a school’s mission, and increasing the use of a new survey instrument.
Keywords: Sociocultural, reconstructionism, problem-based learning, wicked problems, sustainability education, scaffolding, collaboration, interdependency
Graphical scaffolding for the learning of data wrangling APIs
In order for students across the sciences to avail themselves of modern data streams, they must first know how to wrangle data: how to reshape ill-organised, tabular data into another format, and how to do this programmatically, in languages such as Python and R. Despite the cross-departmental demand and the ubiquity of data wrangling in analytical workflows, the research on how to optimise the instruction of it has been minimal. Although data wrangling as a programming domain presents distinctive challenges - characterised by on-the-fly syntax lookup and code example integration - it also presents opportunities. One such opportunity is how tabular data structures are easily visualised. To leverage the inherent visualisability of data wrangling, this dissertation evaluates three types of graphics that could be employed as scaffolding for novices: subgoal graphics, thumbnail graphics, and parameter graphics. Using a specially built e-learning platform, this dissertation documents a multi-institutional, randomised, and controlled experiment that investigates the pedagogical effects of these. Our results indicate that the graphics are well-received, that subgoal graphics boost the completion rate, and that thumbnail graphics improve navigability within a command menu. We also obtained several non-significant results, and indications that parameter graphics are counter-productive. We will discuss these findings in the context of general scaffolding dilemmas, and how they fit into a wider research programme on data wrangling instruction
The fairy tale therapist
Creative Work: The Fairy Tale Therapist:-
My original intention was to create a new form of self-help book using fairy tale characters to address psychological problems. The book I wrote does use fairy tale characters to address psychological problems, but it isn’t written as a typical self-help book.
Instead, it’s the story of Helen, a therapist whose personal life suddenly and dramatically falls apart. Her solution? Not one she would suggest to her clients. She leaves everyone she knows and sets up a new practice in a small village in Wales, where her troubles start to fade. Until, that is, the fairy tale characters start coming in through her office window.
Contextualising Research: The Fragility of Equilibrium in Therapy and Writing:-
In this part of the thesis, I explore the methodologies, underpinning literature and the personal journey of discovery that led to the final book. I examine bibliotherapy, the self-help genre and case studies after selecting a canon of well-known self-help books. I then review classical fairy tales and I try using fairy tale characters rather than case studies as examples in a self-help book. I present these attempts and argue why this straight substitution doesn’t work well. Instead, therefore, I decided to use fairy tale characters’ dilemmas to illustrate the process of psychotherapy, so readers can better understand the aims and processes in therapy, and see inside a therapist’s mind.
The resulting book ('The Fairy Tale Therapist', the creative part of my thesis), raised two further questions which I answer and explore in the critical component.
Is there a concept that is central both to writing fiction and to carrying out/undergoing psychotherapy, and if so how does it achieve this? Story is the bridge that links these disciplines, and I found the key within story is the concept of equilibrium, the desire to return to a stable state an organism is disrupted by a challenge. Equilibrium is, however, elusive: once achieved, disequilibrium begins again.
How might changing perspective help to better understand characters in fiction and clients in therapy/self-help? I found that by adhering to the plot but looking at what happens from a different perspective, as an author I gained a deeper understanding of characters other than the central character. I can also apply this technique to help my patients. Instead of trying to change what’s going on outside of themselves, I can challenge them to try changing the way they consider what’s going on, and in so doing help them to learn to accept—perhaps even celebrate—their circumstances
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