Introduction to the Special Issue on Approaches to Control Biological and Biologically Inspired Networks

The emerging field at the intersection of quantitative biology, network modeling, and control theory has enjoyed significant progress in recent years. This Special Issue brings together a selection of papers on complementary approaches to observe, identify, and control biological and biologically inspired networks. These approaches advance the state of the art in the field by addressing challenges common to many such networks, including high dimensionality, strong nonlinearity, uncertainty, and limited opportunities for observation and intervention. Because these challenges are not unique to biological systems, it is expected that many of the results presented in these contributions will also find applications in other domains, including physical, social, and technological networks

Minimal Driver Nodes for Structural Controllability of Large-Scale Dynamical Systems: Node Classification

This paper considers the problem of minimal control inputs to affect the system states such that the resulting system is structurally controllable. This problem and the dual problem of minimal observability are claimed to have no polynomial-order exact solution and, therefore, are NP-hard. Here, adopting a graph-theoretic approach, this problem is solved for general nonlinear (and also structure-invariant) systems and a P-order solution is proposed. In this direction, the dynamical system is modeled as a directed graph, called \textit{system digraph}, and two types of graph components are introduced which are tightly related with structural controllability. Two types of nodes which are required to be affected (or driven) by an input, called \textit{driver nodes}, are defined, and minimal number of these driver nodes are obtained. Polynomial-order complexity of the given algorithms to solve the problem ensures applicability of the solution for analysis of large-scale dynamical systems. {The structural results in this paper are significant as compared to the existing literature which offer approximate and computationally less-efficient, e.g. Gramian-based, solutions for the problem, while this paper provides exact solution with lower computational complexity and applicable for controllability analysis of nonlinear systems.Comment: accepted at IEEE Systems Journa