A Note on Diphthongization

published or submitted for publicationis peer reviewe

The charybdotoxin receptor of a Shaker K+ channel: peptide and channel residues mediating molecular recognition.

Charybdotoxin (CTX) is a peptide of known structure that inhibits Shaker K+ channels by a pore-blocking mechanism. Point mutagenesis of all 30 solvent-exposed residues identified the part of the CTX molecular surface making contact with the receptor in the K+ channel. All close-contact residues are clustered in a well-defined interaction surface; the shape of this surface implies that the outer opening of the Shaker channel conduction pore abruptly widens to a 25 x 35 A plateau. A mutagenic scan of the S5-S6 linker sequence of the Shaker K+ channel identified those channel residues influencing CTX binding affinity. The Shaker residues making the strongest contribution to toxin binding are located close to the pore-lining sequence, and more distant residues on both sides of this region influence CTX binding weakly, probably by an electrostatic mechanism. Complementary mutagenesis of both CTX and Shaker suggests that Shaker-F425 contacts a specific area near T8 and T9 on the CTX molecular surface. This contact point constrains Shaker-F425 to be located at a 20 A radial distance from the pore axis and 10-15 A above the "floor" of the CTX receptor

English Centering Diphthong Production By Polish Learners of English

The paper shows how British English centering diphthongs are adapted to the vowel space of Polish learners of English. The goal is to focus on complex vowels and the interaction of qualitative and quantitative features. Acoustic analysis revealed various processes used to overcome pronunciation difficulties: /j/ and /w/ breaking, /r/ insertion, substitutions of other vocalic qualities, changes in diphthong duration and diphthong phases duration, and changes in the rate of frequency change

Sherlock Holmes: An expert’s view of expertise

In recent years, there has been an intense research effort to understand the cognitive processes and structures underlying expert behaviour. Work in different fields, including scientific domains, sports, games, and mnemonics, has shown that there are vast differences in perceptual abilities between experts and novices, and that these differences may underpin other cognitive differences in learning, memory, and problem solving. In this article, we evaluate the progress made in the last years through the eyes of an outstanding, albeit fictional, expert: Sherlock Holmes. We first use the Sherlock Holmes character to illustrate expert processes as described by current research and theories. In particular, the role of perception, as well as the nature and influence of expert knowledge, are all present in the description of Conan Doyle’s hero. In the second part of the article, we discuss a number of issues that current research on expertise has barely addressed. These gaps include, for example, several forms of reasoning, the influence of emotions on cognition, and the effect of age on experts’ knowledge and cognitive processes. Thus, although nearly 120 years old, Conan Doyle’s books show remarkable illustrations of expert behaviour, including the coverage of themes that have mostly been overlooked by current research

At Risk: The Bay Area Greenbelt

In 2006, Greenbelt Alliance, the Bay Area's land conservation and urban planning organization, published the newest edition of its landmark study on the state of the region's landscapes. The report found that if current development patterns continue, roughly one out of every 10 acres in the entire Bay Area could be paved over in the next thirty years. Today, there are 401,500 acres of greenbelt lands at risk of sprawl development. That includes 125,200 acres at risk within the next 10 years, classified as high-risk land, and 276,200 acres at risk within the next 10 to 30 years, classified as medium-risk land. Around the region, the places at highest risk -- the sprawl hot spots -- include the I-80 corridor in Solano County, the eastern cities in Contra Costa County, Coyote Valley in southern Santa Clara County, the Tri-Valley area of Alameda and Contra Costa Counties, and areas along Highway 101 through Sonoma County

Bay Area Smart Growth Scorecard

The Bay Area Smart Growth Scorecard is a landmark assessment of the planning policies of all 110 cities and counties of the San Francisco Bay Area.Although a city's current development is apparent to anyone who visits it, the policies that guide a city's future development are not so obvious. The Smart Growth Scorecard provides the first view into these policies and the first comparison among them.The Smart Growth Scorecard evaluated 101 cities in seven policy areas:preventing sprawl; making sure parks are nearby; creating homes people can afford; encouraging a mix of uses; encouraging density in the right places; requiring less land for parking; defining standards for good development. On average, Bay Area cities scored 34% (of a possible 100%), meaning cities are doing only a third of what they could be to achieve smart growth.The Smart Growth Scorecard evaluated eight counties (San Francisco is treated as a city) in five policy areas:managing growth; permanently protecting open space; preserving agricultural land; conserving natural resources; and offering transportation choices. On average, Bay Area counties scored 51%.The scores are low overall. But in every policy area, at least one city or county is doing well, whether it is a city that is encouraging walkable neighborhoods, or a county that is preserving its agricultural land. The Association of Bay Area Governments estimates that Bay Area will have one million additional residents by 2020; the Smart Growth Scorecard evaluates how well all the region's jurisdictions are planning for that growth, and how they can do better

Illustrations and associative logic. Short circuits between images of science, art and architecture / Illustrazioni e logiche associative. Cortocircuiti tra immagini della scienza, dell'arte e dell'architettura

Le illustrazioni di carattere scientifico non servono solo per veicolare informazioni tra addetti che operano nello stesso ambito all’interno del quale sono concepite e generate. Spesso modelli concettuali espressi attraverso illustrazioni possono migrare tra discipline diverse aprendo possibilità di inaspettati sviluppi. Le immagini, infatti, hanno il potere di comunicare suggestioni diverse, andando dunque oltre al loro compito di raffigurare i contenuti per i quali sono state elaborate. Forme, colori, artifici comunicativi, schemi, notazioni, ideogrammi, figure geometriche, forme diverse di rappresentazione possono “rivelare” e restituire il visibile ma anche “costruire” un’idea del possibile. Le immagini hanno dunque il potere di poter parlare a tutti a prescindere dalla condivisione dei codici figurativi che usano. Anche qualora non si parli lo stesso “linguaggio iconico” e si incorra in fraintendimenti, Hans Georg Gadamer ci ha insegnato che questi non sempre generano conseguenze negative, anzi, possono aprire nuove strade interpretative. Le immagini organizzano, d'altronde, la nostra memoria e il nostro pensiero e sono in grado di far scaturire una molteplicità di associazioni – come ha dimostrato Aby Warburg con la pratica ermeneutica esercitata sulle immagini nel suo Bilderatlas. La proprietà associativa è d’altra parte peculiare dell’immagine e ci consente di cogliere, di ricordare e di rivelare tanto elementi della realtà quanto interi sistemi di ordinamento della nostra memoria e dei nostri modi di interagire con la realtà stessa. Quando operiamo per alterare la realtà percepibile producendo nuove immagini, come avviene con l’arte o l’architettura, è inevitabile che la creatività si alimenti con altre immagini e suggestioni. Il gioco dei rimandi può essere più o meno esplicitato nell’opera compiuta, ma sarà comunque colto in virtù delle proprietà associative che sarà in grado di sollecitare dando vita a sua volta a nuove possibilità di sviluppi figurativi e/o concettuali.Although the main purpose of scientific illustrations is to facilitate the sharing of information between operators working in environments in which they are widely understood, drawings of conceptual models may also be used in other fields, often with the consequence of generating new, unexpected developments. The power of images to communicate ideas other than the contents for which they were originally designed means that shapes, colours, communicational expedients, diagrams, notes, ideographs, geometric figures and different forms of representation not only “show the visible” but also propose a way of “constructing the possible”. Indeed, images have the power to speak to everyone, regardless of their knowledge of the figurative codes employed. Even when those who ‘read’ the images are familiar with different “iconic languages” and there is a strong risk of misunderstanding, Hans Georg Gadamer teaches us that this does not always lead to negative results but, on the contrary, often paves the way for new interpretations. Images organize our memory and thoughts and enable us to generate multitudes of associations, as demonstrated by Aby Warburg’s exploitation of hermeneutics in the composition of Der Bilderatlas: Mnemosyne. However, the ability to stimulate the power of association is a feature peculiar to the image as images enable us to capture, remember and exploit not only elements of reality but also entire systems of ordering our memories and interacting with reality. Inevitably, when artists or architects endeavour to change perceived reality by producing new images, their creativity is fuelled by other images and ideas. Yet, regardless of the degree of explicitness of the references used in the finished work, the references are understood as a result of the power of association. This is the key to generating new figurative and/or conceptual developments

Caterina Sforza and Experimenti Translation into English and historical-linguistic analysis of some of her recipes

Caterina Sforza, Countess of Forlì from 1480 to 1500, was an intrepid and shrewd ruler, a mother, a lover, a woman with an eager interest in every field of knowledge, especially in science and experiments. Throughout her whole life, she devoted herself to experimenting and collecting hundreds of alchemical, cosmetic and medical recipes in a manuscript today known as “Experimenti”. This paper will include two chapters: in the first one, a biography of Caterina Sforza will be presented, together with a paragraph dedicated to her passion for botany and chemistry, which represent the foundation for her collection of recipes. Then, the reader will find a narration of the many changes of ownership and adventurous vicissitudes her manuscript experienced, thanks to which it is today possible to access Caterina’s remedies. The second chapter will contain the translation into present-day English of six recipes found in “Experimenti”. Each translation will be followed by the historical-linguistic analysis of some key words extracted from the original recipes: the analysis will base on the comparison between their Renaissance Italian translation and their current English meaning and spelling. An essential tool for this will be John Florio’s dictionary, first published in 1598 and considered the first extensive Italian-English dictionary. The aim of this paper is not only to make Caterina’s experiments accessible to an English public, but also to explore the development of the English language on different levels. Firstly, its evolution in time, from Early Modern English to today’s English. Secondly, its evolution in space, taking into consideration its immense spread all over the world through colonization (which, at the time Caterina Sforza and John Florio were alive, had only just begun), and the consequent many varieties of English existing now. Thirdly, its evolution with regard to the Italian language and culture

Magnetic oxide semiconductors

Magnetic oxide semiconductors, oxide semiconductors doped with transition metal elements, are one of the candidates for a high Curie temperature ferromagnetic semiconductor that is important to realize semiconductor spintronics at room temperature. We review in this paper recent progress of researches on various magnetic oxide semiconductors. The magnetization, magneto-optical effect, and magneto-transport such as anomalous Hall effect are examined from viewpoint of feasibility to evaluate the ferromagnetism. The ferromagnetism of Co-doped TiO2 and transition metal-doped ZnO is discussed.Comment: 26 pages, 5 tables, 6 figure

Introduction. Reconsidering Some Dogmas About Desire

Desire has not been at the center of recent preoccupations in the philosophy of mind. Consequently, the literature settled into several dogmas. The first part of this introduction presents these dogmas and invites readers to scrutinize them. The main dogma is that desires are motivational states. This approach contrasts with the other dominant conception: desires are positive evaluations. But there are at least four other dogmas: the world should conform to our desires (world-to-mind direction of fit), desires involve a positive evaluation (the “guise of the good”), we cannot desire what we think is actual (the “death of desire” principle), and, in neuroscience, the idea that the reward system is the key to understanding desire. The second part of the introduction summarizes the contributions to this volume. The hope is to contribute to the emergence of a fruitful debate on this neglected, albeit crucial, aspect of the mind