34 research outputs found
Deep Learning Framework for Spleen Volume Estimation from 2D Cross-sectional Views
Abnormal spleen enlargement (splenomegaly) is regarded as a clinical
indicator for a range of conditions, including liver disease, cancer and blood
diseases. While spleen length measured from ultrasound images is a commonly
used surrogate for spleen size, spleen volume remains the gold standard metric
for assessing splenomegaly and the severity of related clinical conditions.
Computed tomography is the main imaging modality for measuring spleen volume,
but it is less accessible in areas where there is a high prevalence of
splenomegaly (e.g., the Global South). Our objective was to enable automated
spleen volume measurement from 2D cross-sectional segmentations, which can be
obtained from ultrasound imaging. In this study, we describe a variational
autoencoder-based framework to measure spleen volume from single- or dual-view
2D spleen segmentations. We propose and evaluate three volume estimation
methods within this framework. We also demonstrate how 95% confidence intervals
of volume estimates can be produced to make our method more clinically useful.
Our best model achieved mean relative volume accuracies of 86.62% and 92.58%
for single- and dual-view segmentations, respectively, surpassing the
performance of the clinical standard approach of linear regression using manual
measurements and a comparative deep learning-based 2D-3D reconstruction-based
approach. The proposed spleen volume estimation framework can be integrated
into standard clinical workflows which currently use 2D ultrasound images to
measure spleen length. To the best of our knowledge, this is the first work to
achieve direct 3D spleen volume estimation from 2D spleen segmentations.Comment: 22 pages, 7 figure
Unsupervised Medical Image Translation Using Cycle-MedGAN
Image-to-image translation is a new field in computer vision with multiple
potential applications in the medical domain. However, for supervised image
translation frameworks, co-registered datasets, paired in a pixel-wise sense,
are required. This is often difficult to acquire in realistic medical
scenarios. On the other hand, unsupervised translation frameworks often result
in blurred translated images with unrealistic details. In this work, we propose
a new unsupervised translation framework which is titled Cycle-MedGAN. The
proposed framework utilizes new non-adversarial cycle losses which direct the
framework to minimize the textural and perceptual discrepancies in the
translated images. Qualitative and quantitative comparisons against other
unsupervised translation approaches demonstrate the performance of the proposed
framework for PET-CT translation and MR motion correction.Comment: Submitted to EUSIPCO 2019, 5 page
Deep Semantic Segmentation of Natural and Medical Images: A Review
The semantic image segmentation task consists of classifying each pixel of an
image into an instance, where each instance corresponds to a class. This task
is a part of the concept of scene understanding or better explaining the global
context of an image. In the medical image analysis domain, image segmentation
can be used for image-guided interventions, radiotherapy, or improved
radiological diagnostics. In this review, we categorize the leading deep
learning-based medical and non-medical image segmentation solutions into six
main groups of deep architectural, data synthesis-based, loss function-based,
sequenced models, weakly supervised, and multi-task methods and provide a
comprehensive review of the contributions in each of these groups. Further, for
each group, we analyze each variant of these groups and discuss the limitations
of the current approaches and present potential future research directions for
semantic image segmentation.Comment: 45 pages, 16 figures. Accepted for publication in Springer Artificial
Intelligence Revie