3,699 research outputs found
Neural coding of naturalistic motion stimuli
We study a wide field motion sensitive neuron in the visual system of the
blowfly {\em Calliphora vicina}. By rotating the fly on a stepper motor outside
in a wooded area, and along an angular motion trajectory representative of
natural flight, we stimulate the fly's visual system with input that approaches
the natural situation. The neural response is analyzed in the framework of
information theory, using methods that are free from assumptions. We
demonstrate that information about the motion trajectory increases as the light
level increases over a natural range. This indicates that the fly's brain
utilizes the increase in photon flux to extract more information from the
photoreceptor array, suggesting that imprecision in neural signals is dominated
by photon shot noise in the physical input, rather than by noise generated
within the nervous system itself.Comment: 15 pages, 4 figure
Sequential Sparsening by Successive Adaptation in Neural Populations
In the principal cells of the insect mushroom body, the Kenyon cells (KC),
olfactory information is represented by a spatially and temporally sparse code.
Each odor stimulus will activate only a small portion of neurons and each
stimulus leads to only a short phasic response following stimulus onset
irrespective of the actual duration of a constant stimulus. The mechanisms
responsible for the sparse code in the KCs are yet unresolved.
Here, we explore the role of the neuron-intrinsic mechanism of
spike-frequency adaptation (SFA) in producing temporally sparse responses to
sensory stimulation in higher processing stages. Our single neuron model is
defined through a conductance-based integrate-and-fire neuron with
spike-frequency adaptation [1]. We study a fully connected feed-forward network
architecture in coarse analogy to the insect olfactory pathway. A first layer
of ten neurons represents the projection neurons (PNs) of the antenna lobe. All
PNs receive a step-like input from the olfactory receptor neurons, which was
realized by independent Poisson processes. The second layer represents 100 KCs
which converge onto ten neurons in the output layer which represents the
population of mushroom body extrinsic neurons (ENs).
Our simulation result matches with the experimental observations. In
particular, intracellular recordings of PNs show a clear phasic-tonic response
that outlasts the stimulus [2] while extracellular recordings from KCs in the
locust express sharp transient responses [3]. We conclude that the
neuron-intrinsic mechanism is can explain a progressive temporal response
sparsening in the insect olfactory system. Further experimental work is needed
to test this hypothesis empirically.
[1] Muller et. al., Neural Comput, 19(11):2958-3010, 2007. [2] Assisi et.
al., Nat Neurosci, 10(9):1176-1184, 2007. [3] Krofczik et. al. Front. Comput.
Neurosci., 2(9), 2009.Comment: 5 pages, 2 figures, This manuscript was submitted for review to the
Eighteenth Annual Computational Neuroscience Meeting CNS*2009 in Berlin and
accepted for oral presentation at the meetin
The iso-response method
Throughout the nervous system, neurons integrate high-dimensional input streams and transform them into an output of their own. This integration of incoming signals involves filtering processes and complex non-linear operations. The shapes of these filters and non-linearities determine the computational features of single neurons and their functional roles within larger networks. A detailed characterization of signal integration is thus a central ingredient to understanding information processing in neural circuits. Conventional methods for measuring single-neuron response properties, such as reverse correlation, however, are often limited by the implicit assumption that stimulus integration occurs in a linear fashion. Here, we review a conceptual and experimental alternative that is based on exploring the space of those sensory stimuli that result in the same neural output. As demonstrated by recent results in the auditory and visual system, such iso-response stimuli can be used to identify the non-linearities relevant for stimulus integration, disentangle consecutive neural processing steps, and determine their characteristics with unprecedented precision. Automated closed-loop experiments are crucial for this advance, allowing rapid search strategies for identifying iso-response stimuli during experiments. Prime targets for the method are feed-forward neural signaling chains in sensory systems, but the method has also been successfully applied to feedback systems. Depending on the specific question, “iso-response” may refer to a predefined firing rate, single-spike probability, first-spike latency, or other output measures. Examples from different studies show that substantial progress in understanding neural dynamics and coding can be achieved once rapid online data analysis and stimulus generation, adaptive sampling, and computational modeling are tightly integrated into experiments
Intrinsic Motivation and Mental Replay enable Efficient Online Adaptation in Stochastic Recurrent Networks
Autonomous robots need to interact with unknown, unstructured and changing
environments, constantly facing novel challenges. Therefore, continuous online
adaptation for lifelong-learning and the need of sample-efficient mechanisms to
adapt to changes in the environment, the constraints, the tasks, or the robot
itself are crucial. In this work, we propose a novel framework for
probabilistic online motion planning with online adaptation based on a
bio-inspired stochastic recurrent neural network. By using learning signals
which mimic the intrinsic motivation signalcognitive dissonance in addition
with a mental replay strategy to intensify experiences, the stochastic
recurrent network can learn from few physical interactions and adapts to novel
environments in seconds. We evaluate our online planning and adaptation
framework on an anthropomorphic KUKA LWR arm. The rapid online adaptation is
shown by learning unknown workspace constraints sample-efficiently from few
physical interactions while following given way points.Comment: accepted in Neural Network
How adaptation currents change threshold, gain and variability of neuronal spiking
Many types of neurons exhibit spike rate adaptation, mediated by intrinsic
slow -currents, which effectively inhibit neuronal responses. How
these adaptation currents change the relationship between in-vivo like
fluctuating synaptic input, spike rate output and the spike train statistics,
however, is not well understood. In this computational study we show that an
adaptation current which primarily depends on the subthreshold membrane voltage
changes the neuronal input-output relationship (I-O curve) subtractively,
thereby increasing the response threshold. A spike-dependent adaptation current
alters the I-O curve divisively, thus reducing the response gain. Both types of
adaptation currents naturally increase the mean inter-spike interval (ISI), but
they can affect ISI variability in opposite ways. A subthreshold current always
causes an increase of variability while a spike-triggered current decreases
high variability caused by fluctuation-dominated inputs and increases low
variability when the average input is large. The effects on I-O curves match
those caused by synaptic inhibition in networks with asynchronous irregular
activity, for which we find subtractive and divisive changes caused by external
and recurrent inhibition, respectively. Synaptic inhibition, however, always
increases the ISI variability. We analytically derive expressions for the I-O
curve and ISI variability, which demonstrate the robustness of our results.
Furthermore, we show how the biophysical parameters of slow
-conductances contribute to the two different types of adaptation
currents and find that -activated -currents are
effectively captured by a simple spike-dependent description, while
muscarine-sensitive or -activated -currents show a
dominant subthreshold component.Comment: 20 pages, 8 figures; Journal of Neurophysiology (in press
Neural synchrony in cortical networks : history, concept and current status
Following the discovery of context-dependent synchronization of oscillatory neuronal responses in the visual system, the role of neural synchrony in cortical networks has been expanded to provide a general mechanism for the coordination of distributed neural activity patterns. In the current paper, we present an update of the status of this hypothesis through summarizing recent results from our laboratory that suggest important new insights regarding the mechanisms, function and relevance of this phenomenon. In the first part, we present recent results derived from animal experiments and mathematical simulations that provide novel explanations and mechanisms for zero and nero-zero phase lag synchronization. In the second part, we shall discuss the role of neural synchrony for expectancy during perceptual organization and its role in conscious experience. This will be followed by evidence that indicates that in addition to supporting conscious cognition, neural synchrony is abnormal in major brain disorders, such as schizophrenia and autism spectrum disorders. We conclude this paper with suggestions for further research as well as with critical issues that need to be addressed in future studies
Neural synchrony in cortical networks : history, concept and current status
Following the discovery of context-dependent synchronization of oscillatory neuronal responses in the visual system, the role of neural synchrony in cortical networks has been expanded to provide a general mechanism for the coordination of distributed neural activity patterns. In the current paper, we present an update of the status of this hypothesis through summarizing recent results from our laboratory that suggest important new insights regarding the mechanisms, function and relevance of this phenomenon. In the first part, we present recent results derived from animal experiments and mathematical simulations that provide novel explanations and mechanisms for zero and nero-zero phase lag synchronization. In the second part, we shall discuss the role of neural synchrony for expectancy during perceptual organization and its role in conscious experience. This will be followed by evidence that indicates that in addition to supporting conscious cognition, neural synchrony is abnormal in major brain disorders, such as schizophrenia and autism spectrum disorders. We conclude this paper with suggestions for further research as well as with critical issues that need to be addressed in future studies
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