561 research outputs found
Theory of polygonal phases self-assembled from T-shaped liquid crystalline polymers
Extensive experimental studies have shown that numerous ordered phases can be
formed via the self-assembly of T-shaped liquid crystalline polymers (TLCPs)
composed of a rigid backbone, two flexible end chains and a flexible side
chain. However, a comprehensive understanding of the stability and formation
mechanisms of these intricately nano-structured phases remains incomplete. Here
we fill this gap by carrying out a theoretical study of the phase behaviour of
TLCPs. Specifically, we construct phase diagrams of TLCPs by computing the free
energy of different ordered phases of the system. Our results reveal that the
number of polygonal edges increases as the length of side chain or interaction
strength increases, consistent with experimental observations. The theoretical
study not only reproduces the experimentally observed phases and phase
transition sequences, but also systematically analyzes the stability mechanism
of the polygonal phases
Asymptotically Compatible Schemes for Nonlocal Ohta Kawasaki Model
We study the asymptotical compatibility of the Fourier spectral method in
multidimensional space for the Nonlocal Ohta-Kawasaka (NOK) model, which is
proposed in our previous work. By introducing the Fourier collocation
discretization for the spatial variable, we show that the asymptotical
compatibility holds in 2D and 3D over a periodic domain. For the temporal
discretization, we adopt the second-order backward differentiation formula
(BDF) method. We prove that for certain nonlocal kernels, the proposed time
discretization schemes inherit the energy dissipation law. In the numerical
experiments, we verify the asymptotical compatibility, the second-order
temporal convergence rate, and the energy stability of the proposed schemes.
More importantly, we discover a novel square lattice pattern when certain
nonlocal kernel are applied in the model. In addition, our numerical
experiments confirm the existence of an upper bound for the optimal number of
bubbles in 2D for some specific nonlocal kernels. Finally, we numerically
explore the promotion/demotion effect induced by the nonlocal horizon, which is
consistent with the theoretical studies presented in our earlier work
A finite element approach to self-consistent field theory calculations of multiblock polymers
Self-consistent field theory (SCFT) has proven to be a powerful tool for
modeling equilibrium microstructures of soft materials, particularly for
multiblock polymers. A very successful approach to numerically solving the SCFT
set of equations is based on using a spectral approach. While widely
successful, this approach has limitations especially in the context of current
technologically relevant applications. These limitations include non-trivial
approaches for modeling complex geometries, difficulties in extending to
non-periodic domains, as well as non-trivial extensions for spatial adaptivity.
As a viable alternative to spectral schemes, we develop a finite element
formulation of the SCFT paradigm for calculating equilibrium polymer
morphologies. We discuss the formulation and address implementation challenges
that ensure accuracy and efficiency. We explore higher order chain contour
steppers that are efficiently implemented with Richardson Extrapolation. This
approach is highly scalable and suitable for systems with arbitrary shapes. We
show spatial and temporal convergence and illustrate scaling on up to 2048
cores. Finally, we illustrate confinement effects for selected complex
geometries. This has implications for materials design for nanoscale
applications where dimensions are such that equilibrium morphologies
dramatically differ from the bulk phases
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Tuning the corona-core ratio of polyplex micelles for selective oligonucleotide delivery to hepatocytes or hepatic immune cells
Targeted delivery of oligonucleotides or small molecular drugs to hepatocytes, the liver's parenchymal cells, is challenging without targeting moiety due to the highly efficient mononuclear phagocyte system (MPS) of the liver. The MPS comprises Kupffer cells and specialized sinusoidal endothelial cells, efficiently clearing nanocarriers regardless of their size and surface properties. Physiologically, this non-parenchymal shield protects hepatocytes; however, these local barriers must be overcome for drug delivery. Nanocarrier structural properties strongly influence tissue penetration, in vivo pharmacokinetics, and biodistribution profile. Here we demonstrate the in vivo biodistribution of polyplex micelles formed by polyion complexation of short interfering (si)RNA with modified poly(ethylene glycol)-block-poly(allyl glycidyl ether) (PEG-b-PAGE) diblock copolymer that carries amino moieties in the side chain. The ratio between PEG corona and siRNA complexed PAGE core of polyplex micelles was chemically varied by altering the degree of polymerization of PAGE. Applying Raman-spectroscopy and dynamic in silico modeling on the polyplex micelles, we determined the corona-core ratio (CCR) and visualized the possible micellar structure with varying CCR. The results for this model system reveal that polyplex micelles with higher CCR, i.e., better PEG coverage, exclusively accumulate and thus allow passive cell-type-specific targeting towards hepatocytes, overcoming the macrophage-rich reticuloendothelial barrier of the liver
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Synthesis and characterization of functional polymeric materials for use in organic photovoltaics
Norbornene-type monomers with pendant oligothiophene donor and perylene diimide acceptor groups were synthesized and polymerized using ring-opening metathesis polymerization (ROMP) to yield donor and acceptor homopolymers. These semiconducting homopolymers were characterized by UV-Vis and fluorescence spectroscopy to determine absorbance maxima, emission and excitation profiles, optical bandgaps, molar absorbtivities, and quantum yields. The electrochemical behavior of the donor and acceptor materials was characterized by cyclic voltammetry to determine the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy levels of the organic semiconductors. Donor-acceptor diblock copolymers were synthesized using ROMP. Fluorescence spectroscopy demonstrated increased donor emission quenching with decreasing block length. Random donor-acceptor copolymers demonstrated almost complete quenching of the donor emission, likely due to increased donor-acceptor interfaces for charge transfer. Electron paramagnetic resonance spectroscopy (EPR) confirmed the formation of persistent donor radical cations and acceptor radical anions in the block copolymers. Small-angle X-ray scattering (SAXS) demonstrated bulk microphase separation with domain sizes between 24-28 nm. Furthermore, the formation of crystalline structure within the ordered microdomains was also observed. All of these studies indicate that the designed materials may be useful as the active layer in organic photovoltaic applications.
As a route to functional hybrid materials, block copolymers containing a donor-segment and a Lewis-basic oligoethylene glycol segment, for preferential ZnO nanoparticle growth, were synthesized by ROMP. Photophysical and electrochemical characterization demonstrated that the donor electronic properties were maintained upon incorporation into the copolymer. SAXS was used to demonstrate lamellar morphology in bulk films of the symmetric block copolymers. ZnO nanoparticles were synthesized and incorporated into composite thin films with the block copolymers. These composite films demonstrated high photoluminescence quenching, which increased upon thermal annealing, as a result of favorable charge transfer from the photo-excited donor to the ZnO nanoparticles. These studies demonstrate that improved morphology control and self-assembly can increase charge transfer in hybrid materials through increased interfacial area. As an alternative route to directed ZnO nanoparticle growth, a copolymer containing pendant dipicolylamine moieties was synthesized and characterized by photophysical and electrochemical methods.Chemistr
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