Guest editorial foreword to the special issue on intelligent computation for bioinformatics

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Bioinformatics Education—Perspectives and Challenges

This article discusses the evolution of curriculum, instructional methodologies and initiatives supporting the dissemination of bioinformatics. Building on the early applications of informatics to the field of biology, bioinformatics research entails input from the diverse disciplines of mathematics and statistics, physics and chemistry and medicine and pharmacology. Training in bioinformatics remains the oldest and most important rapid introduction approach to learning bioinformatics skills.2 page(s

Partial Least Squares: A Versatile Tool for the Analysis of High-Dimensional Genomic Data

Partial Least Squares (PLS) is a highly efficient statistical regression technique that is well suited for the analysis of high-dimensional genomic data. In this paper we review the theory and applications of PLS both under methodological and biological points of view. Focusing on microarray expression data we provide a systematic comparison of the PLS approaches currently employed, and discuss problems as different as tumor classification, identification of relevant genes, survival analysis and modeling of gene networks

What is Computational Intelligence and where is it going?

What is Computational Intelligence (CI) and what are its relations with Artificial Intelligence (AI)? A brief survey of the scope of CI journals and books with ``computational intelligence'' in their title shows that at present it is an umbrella for three core technologies (neural, fuzzy and evolutionary), their applications, and selected fashionable pattern recognition methods. At present CI has no comprehensive foundations and is more a bag of tricks than a solid branch of science. The change of focus from methods to challenging problems is advocated, with CI defined as a part of computer and engineering sciences devoted to solution of non-algoritmizable problems. In this view AI is a part of CI focused on problems related to higher cognitive functions, while the rest of the CI community works on problems related to perception and control, or lower cognitive functions. Grand challenges on both sides of this spectrum are addressed

Introduction to the Special Issue: The AgentLink III Technical Forums

This article introduces the special issue of ACM Transactions on Autonomous and Adaptive Systems devoted to research papers arising from the three Technical Forum Group meetings held in 2004 and 2005 that were organized and sponsored by the European FP6 Coordination Action AgentLink III

Towards the ontology-based approach for factual information matching

Factual information is information based on facts or relating to facts. The reliability of automatically extracted facts is the main problem of processing factual information. The fact retrieval system remains one of the most effective tools for identifying the information for decision-making. In this work, we explore how can natural language processing methods and problem domain ontology help to check contradictions and mismatches in facts automatically

The E-health Strategic Research Orientation at the Centre for Telematics and Information Technology

This report gives an overview of research themes, research groups and research partners of the E-Health Strategic Research Orientation (SRO) at the University of Twente