Efficient breast cancer classification network with dual squeeze and excitation in histopathological images.

Medical image analysis methods for mammograms, ultrasound, and magnetic resonance imaging (MRI) cannot provide the underline features on the cellular level to understand the cancer microenvironment which makes them unsuitable for breast cancer subtype classification study. In this paper, we propose a convolutional neural network (CNN)-based breast cancer classification method for hematoxylin and eosin (H&E) whole slide images (WSIs). The proposed method incorporates fused mobile inverted bottleneck convolutions (FMB-Conv) and mobile inverted bottleneck convolutions (MBConv) with a dual squeeze and excitation (DSE) network to accurately classify breast cancer tissue into binary (benign and malignant) and eight subtypes using histopathology images. For that, a pre-trained EfficientNetV2 network is used as a backbone with a modified DSE block that combines the spatial and channel-wise squeeze and excitation layers to highlight important low-level and high-level abstract features. Our method outperformed ResNet101, InceptionResNetV2, and EfficientNetV2 networks on the publicly available BreakHis dataset for the binary and multi-class breast cancer classification in terms of precision, recall, and F1-score on multiple magnification levels

Breast Cancer Detection Based on Simplified Deep Learning Technique With Histopathological Image Using BreaKHis Database

Presented here are the results of an investigation conducted to determine the effectiveness of deep learning (DL)-based systems utilizing the power of transfer learning for detecting breast cancer in histopathological images. It is shown that DL models that are not specifically developed for breast cancer detection can be trained using transfer learning to effectively detect breast cancer in histopathological images. The outcome of the analysis enables the selection of the best DL architecture for detecting cancer with high accuracy. This should facilitate pathologists to achieve early diagnoses of breast cancer and administer appropriate treatment to the patient. The experimental work here used the BreaKHis database consisting of 7909 histopathological pictures from 82 clinical breast cancer patients. The strategy presented for DL training uses various image processing techniques for extracting various feature patterns. This is followed by applying transfer learning techniques in the deep convolutional networks like ResNet, ResNeXt, SENet, Dual Path Net, DenseNet, NASNet, and Wide ResNet. Comparison with recent literature shows that ResNext-50, ResNext-101, DPN131, DenseNet-169 and NASNet-A provide an accuracy of 99.8%, 99.5%, 99.675%, 99.725%, and 99.4%, respectively, and outperform previous studies

Breast cancer detection based on simplified deep learning technique with histopathological image using BreaKHis database

Presented here are the results of an investigation conducted to determine the effectiveness of deep learning (DL)-based systems utilizing the power of transfer learning for detecting breast cancer in histopathological images. It is shown that DL models that are not specifically developed for breast cancer detection can be trained using transfer learning to effectively detect breast cancer in histopathological images. The outcome of the analysis enables the selection of the best DL architecture for detecting cancer with high accuracy. This should facilitate pathologists to achieve early diagnoses of breast cancer and administer appropriate treatment to the patient. The experimental work here used the BreaKHis database consisting of 7909 histopathological pictures from 82 clinical breast cancer patients. The strategy presented for DL training uses various image processing techniques for extracting various feature patterns. This is followed by applying transfer learning techniques in the deep convolutional networks like ResNet, ResNeXt, SENet, Dual Path Net, DenseNet, NASNet, and Wide ResNet. Comparison with recent literature shows that ResNext-50, ResNext-101, DPN131, DenseNet-169 and NASNet-A provide an accuracy of 99.8%, 99.5%, 99.675%, 99.725%, and 99.4%, respectively, and outperform previous studies

Breast Cancer Classification from Histopathological Images Using Transfer Learning and Deep Neural Networks

Early diagnosis of breast cancer is the most reliable and practical approach to managing cancer. Computer-aided detection or computer-aided diagnosis is one of the software technology designed to assist doctors in detecting or diagnose cancer and reduce mortality via using the medical image analysis with less time. Recently, medical image analysis used Convolution Neural Networks to evaluate a vast number of data to detect cancer cells or image classification. In this thesis, we implemented transfer learning from pre-trained deep neural networks ResNet18, Inception-V3Net, and ShuffleNet in terms of binary classification and multiclass classification for breast cancer from histopathological images. We use transfer learning with the fine-tuned network results in much faster and less complicated training than a training network with randomly initialized weights from scratch. Our approach is applied to image-based breast cancer classification using histopathological images from public dataset BreakHis. The highest average accuracy achieved for binary classification of benign or malignant cases was 97.11% for ResNet 18, followed by 96.78% for ShuffleNet and 95.65% for Inception-V3Net. In terms of the multiclass classification of eight cancer classes, the average accuracies for pre-trained networks are as follows. ResNet18 achieved 94.17%, Inception-V3Net 92.76% and ShuffleNet 92.27%

Towards Secure and Intelligent Diagnosis: Deep Learning and Blockchain Technology for Computer-Aided Diagnosis Systems

Cancer is the second leading cause of death across the world after cardiovascular disease. The survival rate of patients with cancerous tissue can significantly decrease due to late-stage diagnosis. Nowadays, advancements of whole slide imaging scanners have resulted in a dramatic increase of patient data in the domain of digital pathology. Large-scale histopathology images need to be analyzed promptly for early cancer detection which is critical for improving patient's survival rate and treatment planning. Advances of medical image processing and deep learning methods have facilitated the extraction and analysis of high-level features from histopathological data that could assist in life-critical diagnosis and reduce the considerable healthcare cost associated with cancer. In clinical trials, due to the complexity and large variance of collected image data, developing computer-aided diagnosis systems to support quantitative medical image analysis is an area of active research. The first goal of this research is to automate the classification and segmentation process of cancerous regions in histopathology images of different cancer tissues by developing models using deep learning-based architectures. In this research, a framework with different modules is proposed, including (1) data pre-processing, (2) data augmentation, (3) feature extraction, and (4) deep learning architectures. Four validation studies were designed to conduct this research. (1) differentiating benign and malignant lesions in breast cancer (2) differentiating between immature leukemic blasts and normal cells in leukemia cancer (3) differentiating benign and malignant regions in lung cancer, and (4) differentiating benign and malignant regions in colorectal cancer. Training machine learning models, disease diagnosis, and treatment often requires collecting patients' medical data. Privacy and trusted authenticity concerns make data owners reluctant to share their personal and medical data. Motivated by the advantages of Blockchain technology in healthcare data sharing frameworks, the focus of the second part of this research is to integrate Blockchain technology in computer-aided diagnosis systems to address the problems of managing access control, authentication, provenance, and confidentiality of sensitive medical data. To do so, a hierarchical identity and attribute-based access control mechanism using smart contract and Ethereum Blockchain is proposed to securely process healthcare data without revealing sensitive information to an unauthorized party leveraging the trustworthiness of transactions in a collaborative healthcare environment. The proposed access control mechanism provides a solution to the challenges associated with centralized access control systems and ensures data transparency and traceability for secure data sharing, and data ownership