Folding and Aggregation of Designed Proteins

Studies of how protein fold have shown that the way protein clumps form in the test tube is similar to how proteins form the so-called ``amyloid'' deposits that are the pathological signal of a variety of diseases, among them the memory disorder Alzheimer's. Protein aggregation have traditionally been connected to either unfolded or native states. Inclusion body formation (disordered aggregation) has been assumed to arise from hydrophobic aggregation of the unfolded or denaturated states, while the amyloid fibrils (ordered aggregation) have been assumed to arise from native-like conformations in a process analogous to the polymerization of hemoglobin S. Making use of lattice-model simulations we find that both ordered and disordered aggregation arise from elementary structures which eventually build the folding nucleus of the heteropolymers, and takes place when some of the most strongly interacting amino acids establish their contacts leading to the formation of a specific subset of the native structure. These elementary structures can be viewed as the partially folded intermediates suggested to be involved in the aggregation of a number of proteins. These results have evolutionary implications, as the elementary structures forming the folding core of designed proteins contain the residues which are conserved among the members of homologous sequences.Comment: 10 pages, 2 colour ps figures and 1 b/w ps figur

Social Media And Health: Implications For Primary Health Care Providers

This report is the second deliverable of the ?Digital Inclusion and Social Knowledge Media for Health: Frameworks and Roadmaps? project. The first discussed the concept of social and digital exclusion whilst this report focuses on the emerging phenomenon of social media. The report outlines current knowledge on the users and usages of social media for health and goes on to discuss social media in the context of a continuing focus (ref. D1.1) on the areas of mental health, smoking cessation and teenage lifestyles. The report concludes with an outline of an approach to a ?social media strategy? and with suggestions for directions for future research

Playlab: Telling Stories with Technology (workshop summary)

This one-day workshop explores how playful interaction can be used to develop technologies for public spaces and create temporal experiences

Computer programs and documentation

Various statistical tests that were used to check out random number generators are described. A total of twelve different tests were considered, and from these, six were chosen to be used. The frequency test, max t test, run test, lag product test, gap test, and the matrix test are included