Thermoelastic Properties of Ringwoodite [Fe_x,Mg_(1-x)]_2SiO_4: Its Relationship to the 520 km Seismic Discontinuity

We combine density functional theory (DFT) within the local density approximation (LDA), the quasiharmonic approximation (QHA), and a model vibrational density of states (VDoS) to calculate elastic moduli and sound velocities of gamma-[Fe_x,Mg_(1-x)]_2SiO_4 (ringwoodite), the most abundant mineral of the lower Earth's transition zone (TZ). Comparison with experimental values at room-temperature and high pressure or ambient-pressure and high temperature shows good agreement with our first-principles findings. Then, we investigate the contrasts associated with the beta-to-gamma-[Fe_x,Mg_(1-x)]_2SiO_4 transformation at pressures and temperatures relevant to the TZ. This information offers clearly defined reference values to advance the understanding of the nature of the 520 km seismic discontinuity.Comment: 29 pages, 6 figures, 2 tables. Under Revie

An autoregressive approach to house price modeling

A statistical model for predicting individual house prices and constructing a house price index is proposed utilizing information regarding sale price, time of sale and location (ZIP code). This model is composed of a fixed time effect and a random ZIP (postal) code effect combined with an autoregressive component. The former two components are applied to all home sales, while the latter is applied only to homes sold repeatedly. The time effect can be converted into a house price index. To evaluate the proposed model and the resulting index, single-family home sales for twenty US metropolitan areas from July 1985 through September 2004 are analyzed. The model is shown to have better predictive abilities than the benchmark S&P/Case--Shiller model, which is a repeat sales model, and a conventional mixed effects model. Finally, Los Angeles, CA, is used to illustrate a historical housing market downturn.Comment: Published in at http://dx.doi.org/10.1214/10-AOAS380 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

House of the Setting Sun: New Orleans, Katrina, and The Role of Historic Preservation Laws in Emergency Circumstances

In the aftermath of Hurricane Katrina, while various government bodies scrambled to address the myriad tragedies and emergencies that arose from the disaster, one critical question went largely unanswered and ignored: What was to become of the historic homes damaged in the storm and ensuing flood? Obviously this question was of secondary concern at the time—where human life and safety are imperiled, the primary focus of government officials should be on restoring order and ensuring their constituents are protected. Precisely because of the existence of more pressing issues in a time of emergency, therefore, it is important to have a prepared plan addressing how best to incorporate historic preservation law into recovery and rebuilding efforts. In many areas, and in New Orleans in particular, historic architecture and ambience play a large role in forming the identity of the community; if a community is rebuilt without its identity in mind, its residents will not truly be able to return home. In this paper I will discuss in more detail why a system for addressing historic preservation concerns in a time of emergency is necessary and what that system should entail. Part I includes a description of New Orleans, how the New Orleans historic preservation statute functions, and what the results were in historic districts affected by Hurricane Katrina. Part II is a brief description of other areas that have experienced large-scale disasters, with an exploration into how the various responses affected the goals of historic preservation. Part III details a proposed solution -- that emergency provisions be written into local historic preservation statutes to govern how the statute will function in a time of emergency, and what those provisions should look like. Although the typical procedure put in place by the historic preservation ordinance may not be feasible in a time of emergency, a modified or alternative version of that process would best protect the interests of preservation while allowing local government to sufficiently respond to the needs of the community

An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells.

Duchenne muscular dystrophy is a progressive and incurable neuromuscular disease caused by genetic and biochemical defects of the dystrophin-glycoprotein complex. Here we show the regenerative potential of myogenic progenitors derived from corrected dystrophic induced pluripotent stem cells generated from fibroblasts of mice lacking both dystrophin and utrophin. We correct the phenotype of dystrophic induced pluripotent stem cells using a Sleeping Beauty transposon system carrying the micro-utrophin gene, differentiate these cells into skeletal muscle progenitors and transplant them back into dystrophic mice. Engrafted muscles displayed large numbers of micro-utrophin-positive myofibers, with biochemically restored dystrophin-glycoprotein complex and improved contractile strength. The transplanted cells seed the satellite cell compartment, responded properly to injury and exhibit neuromuscular synapses. We also detect muscle engraftment after systemic delivery of these corrected progenitors. These results represent an important advance towards the future treatment of muscular dystrophies using genetically corrected autologous induced pluripotent stem cells

Searching for high magnetization density in bulk Fe: the new metastable Fe6_6 phase

We report the discovery of a new allotrope of iron by first principles calculations. This phase has $Pmn2_1$ symmetry, a six-atom unit cell (hence the name Fe$_6$), and the highest magnetization density (M$_s$) among all known crystalline phases of iron. Obtained from the structural optimizations of the Fe$_3$C-cementite crystal upon carbon removal, $Pmn2_1$ Fe$_6$ is shown to result from the stabilization of a ferromagnetic FCC phase, further strained along the Bain path. Although metastable from 0 to 50 GPa, the new phase is more stable, at low pressures, than the other well-known HCP and FCC allotropes and smoothly transforms into the FCC phase under compression. If stabilized to room temperature, e.g., by interstitial impurities, Fe$_{6}$ could become the basis material for high M$_s$ rare-earth-free permanent magnets and high-impact applications such as, light-weight electric engine rotors or high-density recording media. The new phase could also be key to explain the enigmatic high M$_s$ of Fe$_{16}$N$_2$, which is currently attracting an intense research activity.Comment: 7 pages, 7 figure

Evaluation of Minnesota Geographic Classifications Based on Caddisfly (Trichoptera) Data

The ability to partition the variation of faunal assemblages into homogenous units valuable for biomonitoring is referred to as classification strength (CS). In this study, the CSs of three types of geographic classifications: watershed basin, ecological region, and caddisfly region, were compared based on 248 light trap samples of adult caddisflies collected in Minnesota during 1999–2001. The effect on CS of three different levels of taxonomic resolution: family, genus, and species, was also assessed. Primary (broadest possible) a priori classification by watershed basin and ecological region had a lower CS than did secondary classification by these regions. Caddisfly region, an a posteriori classification based directly on caddisfly distribution data, had nearly twice the CS of any a priori classification. CS decreased approximately 20% with a decrease in taxonomic resolution from species to genus, and from genus to family. These results suggest that geographic classification, spatial scale, and taxonomic resolution are all important factors to consider when sampling aquatic insects, and that widely used a priori geographic classifications are not the ideal units for sampling the aquatic biota

Evolution of the Second-Story City: The Minneapolis Skyway System

This paper describes and explains the growth of the Minneapolis Skyway network. Accessibility is used as a major factor in understanding that growth (i.e. does the network connect to the location(s) with the highest accessibility, followed by the second highest, and so on). First, employment opportunities are used as the measure of activity and are based off of the square footage of buildings and/or ITE trip generation rates. Using information about the buildings located downtown for each year since the first skyway was built, the accessibilities of each of the connected and adjacent unconnected blocks were calculated for every time period the skyway system expanded. The purpose is to determine how often the expansion connected the block with the highest accessibility. The results show that though important, accessibility was rarely maximized, except in the early stages of development. A connect-choice logit model relating the probability of joining the network (in a given year) to accessibility and network size was employed. The results show accessibility does remain an important factor in predicting which links are connected. Physical difficulties in making connections may have played a role, as well as the potential for adverse economic impacts.Network growth, Transport economics, Incremental connection, Skyways, Minneapolis

Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling.

Matriptase is an epithelia-specific membrane-anchored serine protease that has received considerable attention in recent years because of its consistent dysregulation in human epithelial tumours, including breast cancer. Mice with reduced levels of matriptase display a significant delay in oncogene-induced mammary tumour formation and blunted tumour growth. The abated tumour growth is associated with a decrease in cancer cell proliferation. Here we demonstrate by genetic deletion and silencing that the proliferation impairment in matriptase-deficient breast cancer cells is caused by their inability to initiate activation of the c-Met signalling pathway in response to fibroblast-secreted pro-HGF. Similarly, inhibition of matriptase catalytic activity using a selective small-molecule inhibitor abrogates the activation of c-Met, Gab1 and AKT, in response to pro-HGF, which functionally leads to attenuated proliferation in breast carcinoma cells. We conclude that matriptase is critically involved in breast cancer progression and represents a potential therapeutic target in breast cancer