Adiabatic Quantum Optimization for Associative Memory Recall

Hopfield networks are a variant of associative memory that recall information stored in the couplings of an Ising model. Stored memories are fixed points for the network dynamics that correspond to energetic minima of the spin state. We formulate the recall of memories stored in a Hopfield network using energy minimization by adiabatic quantum optimization (AQO). Numerical simulations of the quantum dynamics allow us to quantify the AQO recall accuracy with respect to the number of stored memories and the noise in the input key. We also investigate AQO performance with respect to how memories are stored in the Ising model using different learning rules. Our results indicate that AQO performance varies strongly with learning rule due to the changes in the energy landscape. Consequently, learning rules offer indirect methods for investigating change to the computational complexity of the recall task and the computational efficiency of AQO.Comment: 22 pages, 11 figures. Updated for clarity and figures, to appear in Frontiers of Physic

Unconventional machine learning of genome-wide human cancer data

Recent advances in high-throughput genomic technologies coupled with exponential increases in computer processing and memory have allowed us to interrogate the complex aberrant molecular underpinnings of human disease from a genome-wide perspective. While the deluge of genomic information is expected to increase, a bottleneck in conventional high-performance computing is rapidly approaching. Inspired in part by recent advances in physical quantum processors, we evaluated several unconventional machine learning (ML) strategies on actual human tumor data. Here we show for the first time the efficacy of multiple annealing-based ML algorithms for classification of high-dimensional, multi-omics human cancer data from the Cancer Genome Atlas. To assess algorithm performance, we compared these classifiers to a variety of standard ML methods. Our results indicate the feasibility of using annealing-based ML to provide competitive classification of human cancer types and associated molecular subtypes and superior performance with smaller training datasets, thus providing compelling empirical evidence for the potential future application of unconventional computing architectures in the biomedical sciences