Cancer diagnosis using deep learning: A bibliographic review

In this paper, we first describe the basics of the field of cancer diagnosis, which includes steps of cancer diagnosis followed by the typical classification methods used by doctors, providing a historical idea of cancer classification techniques to the readers. These methods include Asymmetry, Border, Color and Diameter (ABCD) method, seven-point detection method, Menzies method, and pattern analysis. They are used regularly by doctors for cancer diagnosis, although they are not considered very efficient for obtaining better performance. Moreover, considering all types of audience, the basic evaluation criteria are also discussed. The criteria include the receiver operating characteristic curve (ROC curve), Area under the ROC curve (AUC), F1 score, accuracy, specificity, sensitivity, precision, dice-coefficient, average accuracy, and Jaccard index. Previously used methods are considered inefficient, asking for better and smarter methods for cancer diagnosis. Artificial intelligence and cancer diagnosis are gaining attention as a way to define better diagnostic tools. In particular, deep neural networks can be successfully used for intelligent image analysis. The basic framework of how this machine learning works on medical imaging is provided in this study, i.e., pre-processing, image segmentation and post-processing. The second part of this manuscript describes the different deep learning techniques, such as convolutional neural networks (CNNs), generative adversarial models (GANs), deep autoencoders (DANs), restricted Boltzmann’s machine (RBM), stacked autoencoders (SAE), convolutional autoencoders (CAE), recurrent neural networks (RNNs), long short-term memory (LTSM), multi-scale convolutional neural network (M-CNN), multi-instance learning convolutional neural network (MIL-CNN). For each technique, we provide Python codes, to allow interested readers to experiment with the cited algorithms on their own diagnostic problems. The third part of this manuscript compiles the successfully applied deep learning models for different types of cancers. Considering the length of the manuscript, we restrict ourselves to the discussion of breast cancer, lung cancer, brain cancer, and skin cancer. The purpose of this bibliographic review is to provide researchers opting to work in implementing deep learning and artificial neural networks for cancer diagnosis a knowledge from scratch of the state-of-the-art achievements

Residual-Sparse Fuzzy CC-Means Clustering Incorporating Morphological Reconstruction and Wavelet frames

Instead of directly utilizing an observed image including some outliers, noise or intensity inhomogeneity, the use of its ideal value (e.g. noise-free image) has a favorable impact on clustering. Hence, the accurate estimation of the residual (e.g. unknown noise) between the observed image and its ideal value is an important task. To do so, we propose an $\ell_0$ regularization-based Fuzzy $C$-Means (FCM) algorithm incorporating a morphological reconstruction operation and a tight wavelet frame transform. To achieve a sound trade-off between detail preservation and noise suppression, morphological reconstruction is used to filter an observed image. By combining the observed and filtered images, a weighted sum image is generated. Since a tight wavelet frame system has sparse representations of an image, it is employed to decompose the weighted sum image, thus forming its corresponding feature set. Taking it as data for clustering, we present an improved FCM algorithm by imposing an $\ell_0$ regularization term on the residual between the feature set and its ideal value, which implies that the favorable estimation of the residual is obtained and the ideal value participates in clustering. Spatial information is also introduced into clustering since it is naturally encountered in image segmentation. Furthermore, it makes the estimation of the residual more reliable. To further enhance the segmentation effects of the improved FCM algorithm, we also employ the morphological reconstruction to smoothen the labels generated by clustering. Finally, based on the prototypes and smoothed labels, the segmented image is reconstructed by using a tight wavelet frame reconstruction operation. Experimental results reported for synthetic, medical, and color images show that the proposed algorithm is effective and efficient, and outperforms other algorithms.Comment: 12 pages, 11 figur

Enhanced free space detection in multiple lanes based on single CNN with scene identification

Many systems for autonomous vehicles' navigation rely on lane detection. Traditional algorithms usually estimate only the position of the lanes on the road, but an autonomous control system may also need to know if a lane marking can be crossed or not, and what portion of space inside the lane is free from obstacles, to make safer control decisions. On the other hand, free space detection algorithms only detect navigable areas, without information about lanes. State-of-the-art algorithms use CNNs for both tasks, with significant consumption of computing resources. We propose a novel approach that estimates the free space inside each lane, with a single CNN. Additionally, adding only a small requirement concerning GPU RAM, we infer the road type, that will be useful for path planning. To achieve this result, we train a multi-task CNN. Then, we further elaborate the output of the network, to extract polygons that can be effectively used in navigation control. Finally, we provide a computationally efficient implementation, based on ROS, that can be executed in real time. Our code and trained models are available online.Comment: Will appear in the 2019 IEEE Intelligent Vehicles Symposium (IV 2019

Computerized Analysis of Magnetic Resonance Images to Study Cerebral Anatomy in Developing Neonates

The study of cerebral anatomy in developing neonates is of great importance for the understanding of brain development during the early period of life. This dissertation therefore focuses on three challenges in the modelling of cerebral anatomy in neonates during brain development. The methods that have been developed all use Magnetic Resonance Images (MRI) as source data. To facilitate study of vascular development in the neonatal period, a set of image analysis algorithms are developed to automatically extract and model cerebral vessel trees. The whole process consists of cerebral vessel tracking from automatically placed seed points, vessel tree generation, and vasculature registration and matching. These algorithms have been tested on clinical Time-of- Flight (TOF) MR angiographic datasets. To facilitate study of the neonatal cortex a complete cerebral cortex segmentation and reconstruction pipeline has been developed. Segmentation of the neonatal cortex is not effectively done by existing algorithms designed for the adult brain because the contrast between grey and white matter is reversed. This causes pixels containing tissue mixtures to be incorrectly labelled by conventional methods. The neonatal cortical segmentation method that has been developed is based on a novel expectation-maximization (EM) method with explicit correction for mislabelled partial volume voxels. Based on the resulting cortical segmentation, an implicit surface evolution technique is adopted for the reconstruction of the cortex in neonates. The performance of the method is investigated by performing a detailed landmark study. To facilitate study of cortical development, a cortical surface registration algorithm for aligning the cortical surface is developed. The method first inflates extracted cortical surfaces and then performs a non-rigid surface registration using free-form deformations (FFDs) to remove residual alignment. Validation experiments using data labelled by an expert observer demonstrate that the method can capture local changes and follow the growth of specific sulcus

Burning Skin Detection System in Human Body

Early accurate burn depth diagnosis is crucial for selecting the appropriate clinical intervention strategies and assessing burn patient prognosis quality. However, with limited diagnostic accuracy, the current burn depth diagnosis approach still primarily relies on the empirical subjective assessment of clinicians. With the quick development of artificial intelligence technology, integration of deep learning algorithms with image analysis technology can more accurately identify and evaluate the information in medical images. The objective of the work is to detect and classify burn area in medical images using an unsupervised deep learning algorithm. The main contribution is to developing computations using one of the deep learning algorithm. To demonstrate the effectiveness of the proposed framework, experiments are performed on the benchmark to evaluate system stability. The results indicate that, the proposed system is simple and suits real life applications. The system accuracy was 75%, when compared with some of the state-of-the-art techniques