Development of Neural Electromagnetic Ontologies (NEMO): Ontology-based Tools for Representation and Integration of Event-related Brain Potentials

We describe a first-generation ontology for
representation and integration of event-related brain potentials (ERPs). The ontology is designed following OBO “best practices” and is augmented with tools to perform ontology-based labeling and annotation of ERP data, and a database that enables semantically based reasoning over these data. Because certain high-level concepts in the ERP domain are illdefined, we have developed methods to support coordinated updates to each of these three components. This approach consists of “top-down” (knowledge-driven) design and implementation, followed by “bottom-up” (data-driven) validation and refinement. Our goal is to build an ERP ontology that is logically valid, empirically sound, robust in application, and transparent to users. This ontology will be used to support sharing and meta-analysis of EEG and MEG data collected within our Neural Electromagnetic Ontologies (NEMO) project

Knowledge-based systems and geological survey

This personal and pragmatic review of the philosophy underpinning methods of geological surveying suggests that important influences of information technology have yet to make their impact. Early approaches took existing systems as metaphors, retaining the separation of maps, map explanations and information archives, organised around map sheets of fixed boundaries, scale and content. But system design should look ahead: a computer-based knowledge system for the same purpose can be built around hierarchies of spatial objects and their relationships, with maps as one means of visualisation, and information types linked as hypermedia and integrated in mark-up languages. The system framework and ontology, derived from the general geoscience model, could support consistent representation of the underlying concepts and maintain reference information on object classes and their behaviour. Models of processes and historical configurations could clarify the reasoning at any level of object detail and introduce new concepts such as complex systems. The up-to-date interpretation might centre on spatial models, constructed with explicit geological reasoning and evaluation of uncertainties. Assuming (at a future time) full computer support, the field survey results could be collected in real time as a multimedia stream, hyperlinked to and interacting with the other parts of the system as appropriate. Throughout, the knowledge is seen as human knowledge, with interactive computer support for recording and storing the information and processing it by such means as interpolating, correlating, browsing, selecting, retrieving, manipulating, calculating, analysing, generalising, filtering, visualising and delivering the results. Responsibilities may have to be reconsidered for various aspects of the system, such as: field surveying; spatial models and interpretation; geological processes, past configurations and reasoning; standard setting, system framework and ontology maintenance; training; storage, preservation, and dissemination of digital records

Design of a goal ontology for medical decision-support

Thesis (S.M.)--Harvard-MIT Division of Health Sciences and Technology, 2005.Includes bibliographical references (leaves 34-36).Objectives: There are several ongoing efforts aimed at developing formal models of medical knowledge and reasoning to design decision-support systems. Until now, these efforts have focused primarily on representing content of clinical guidelines and their logical structure. The present study aims to develop a computable representation of health-care providers' intentions to be used as part of a framework for implementing clinical decision-support systems. Our goal is to create an ontology that supports retrieval of plans based on the intentions or goals of the clinician. Methods: We developed an ontological representation of medical goals, plans, clinical scenarios and other relevant entities in medical decision-making. We used the resulting ontology along with an external ontology inference engine to simulate selection of clinical recommendations based on goals. The ontology instances used in the simulation were modeled from two clinical guidelines. Testing the design: Thirty-two clinical recommendations were encoded in the experimental model. Nine test cases were created to verify the ability of the model to retrieve the plans. For all nine cases, plans were successfully retrieved. Conclusion: The ontological design we developed supported effective reasoning over a medical knowledge base.(cont.) The immediate extension of this approach to be fully developed in medical applications may be partially limited by the lack of available editing tools. Many efforts in this area are currently aiming to the development of needed technologies.by Davide Zacacagnini [i.e. Zaccagnini].S.M

Ontology-Based Queries over Cancer Data

The ever-increasing amount of data in biomedical research, and in cancer research in particular, needs to be managed to support efficient data access, exchange and integration. Existing software infrastructures, such as caGrid, support access to distributed information annotated with a domain ontology. However, caGrid's current querying functionality depends on the structure of individual data resources without exploiting the semantic annotations. In this paper, we present the design and development of an ontology-based querying functionality that consists of: the generation of OWL2 ontologies from the underlying data resources’ metadata and a query rewriting and translation process based on reasoning, which converts a query at the domain ontology level into queries at the software infrastructure level. We present a detailed analysis of our approach as well as an extensive performance evaluation. While the implementation and evaluation was performed for the caGrid infrastructure, the approach could be applicable to other model and metadata-driven environments for data sharing

Module Extraction and Incremental Classification: A Pragmatic Approach for EL ⁺ Ontologies

The description logic EL⁺ has recently proved practically useful in the life science domain with presence of several large-scale biomedical ontologies such as Snomed ct. To deal with ontologies of this scale, standard reasoning of classification is essential but not sufficient. The ability to extract relevant fragments from a large ontology and to incrementally classify it has become more crucial to support ontology design, maintenance and reuse. In this paper, we propose a pragmatic approach to module extraction and incremental classification for EL⁺ ontologies and report on empirical evaluations of our algorithms which have been implemented as an extension of the CEL reasoner

An Intelligent Help-Desk Framework for Effective Troubleshooting

Nowadays, technological infrastructure requires an intelligent virtual environment based on decision processes. These processes allow the coordination of individual elements and the tasks that connect them. Thus, incident resolution must be efficient and effective to achieve maximum productivity. In this paper, we present the design and implementation of an intelligent decision-support system applied in technology infrastructure at the University of Seville (Spain). We have used a Case Based Reasoning (CBR) methodology and an ontology to develop an intelligent system for supporting expert diagnosis and intelligent management of incidents. This is an innovative and interdisciplinary approach to knowledge management in problem-solving processes that are related to environmental issues. Our system provides an automatic semantic indexing for the generating of question/answer pairs, a case based reasoning technique for finding similar questions, and an integration of external information sources via ontologies. A real ontology-based question/answer platform named ExpertSOS is presented as a proof of concept. The intelligent diagnosis platform is able to identify and isolate the most likely cause of infrastructure failure in case of a faulty operation

Technical Issues in the Development of Knowledge-Based Services for the Semantic Web

The Semantic Web aims to extend the current Web with formal semantics in order to improve how users experience the Web, by ameliorating current activities and supporting the automation of some others. So far, current Semantic Web prototypes mostly aim at collecting and exposing information. Still, a semantic layer can support applying Knowledge-Based Systems techniques to the development of brand-new fully-fledged Knowledge-Based Services for the Web. In this paper, we present the technical issues that have to be faced in the development of such a kind of application by presenting the Online Design of Events Application: a Semantic Web-based design support system that assists event organisers in the process of preparing events such as workshops and conferences, by effectively reasoning over an inter-organisational process across the Web

Design of an ontology for decision support in VR exposure therapy

Virtual Reality (VR) is finding its way into many domains, including healthcare. Therapists greatly benefit from having any scenario in VR at their disposal for exposure therapy. However, adapting the VR environment to the needs of the patient is time-consuming. Therefore, an intelligent decision support system that takes context information into account would be a big improvement for personalised VR therapy. In this paper, a semantic ontology is presented for modelling relevant concepts and relations in the context of anxiety therapy in VR. The necessary knowledge was collected through workshops with therapists, this resulted in a layered ontology. Furthermore, semantic reasoning through logical rules enables deduction of interesting high-level knowledge from low-level data. The presented ontology is a starting point for further research on intelligent adaptation algorithms for personalised VR exposure therapy

Ambient-aware continuous care through semantic context dissemination

Background: The ultimate ambient-intelligent care room contains numerous sensors and devices to monitor the patient, sense and adjust the environment and support the staff. This sensor-based approach results in a large amount of data, which can be processed by current and future applications, e. g., task management and alerting systems. Today, nurses are responsible for coordinating all these applications and supplied information, which reduces the added value and slows down the adoption rate. The aim of the presented research is the design of a pervasive and scalable framework that is able to optimize continuous care processes by intelligently reasoning on the large amount of heterogeneous care data. Methods: The developed Ontology-based Care Platform (OCarePlatform) consists of modular components that perform a specific reasoning task. Consequently, they can easily be replicated and distributed. Complex reasoning is achieved by combining the results of different components. To ensure that the components only receive information, which is of interest to them at that time, they are able to dynamically generate and register filter rules with a Semantic Communication Bus (SCB). This SCB semantically filters all the heterogeneous care data according to the registered rules by using a continuous care ontology. The SCB can be distributed and a cache can be employed to ensure scalability. Results: A prototype implementation is presented consisting of a new-generation nurse call system supported by a localization and a home automation component. The amount of data that is filtered and the performance of the SCB are evaluated by testing the prototype in a living lab. The delay introduced by processing the filter rules is negligible when 10 or fewer rules are registered. Conclusions: The OCarePlatform allows disseminating relevant care data for the different applications and additionally supports composing complex applications from a set of smaller independent components. This way, the platform significantly reduces the amount of information that needs to be processed by the nurses. The delay resulting from processing the filter rules is linear in the amount of rules. Distributed deployment of the SCB and using a cache allows further improvement of these performance results

Improving Knowledge Retrieval in Digital Libraries Applying Intelligent Techniques

Nowadays an enormous quantity of heterogeneous and distributed information is stored in the digital University. Exploring online collections to find knowledge relevant to a user’s interests is a challenging work. The artificial intelligence and Semantic Web provide a common framework that allows knowledge to be shared and reused in an efficient way. In this work we propose a comprehensive approach for discovering E-learning objects in large digital collections based on analysis of recorded semantic metadata in those objects and the application of expert system technologies. We have used Case Based-Reasoning methodology to develop a prototype for supporting efficient retrieval knowledge from online repositories. We suggest a conceptual architecture for a semantic search engine. OntoUS is a collaborative effort that proposes a new form of interaction between users and digital libraries, where the latter are adapted to users and their surroundings