Research Scenario of Bio Informatics in Big Data Approach

Big Data can unify all patient related data to get a 360-degree view of the patient to analyze and predict outcomes. This investigation examines the concepts and characteristics of Big Data, concepts about Translational Bio Informatics and some public available big data repositories and major issues of big data. This issue covers the area of medical and healthcare applications and its opportunities.

Radial Basis Function-Sparse Partial Least Squares for Application to Brain Imaging Data

Magnetic resonance imaging (MRI) data is an invaluable tool in brain morphology research. Here, we propose a novel statistical method for investigating the relationship between clinical characteristics and brain morphology based on three-dimensional MRI data via radial basis function-sparse partial least squares (RBF-sPLS). Our data consisted of MRI image intensities for multimillion voxels in a 3D array along with 73 clinical variables. This dataset represents a suitable application of RBF-sPLS because of a potential correlation among voxels as well as among clinical characteristics. Additionally, this method can simultaneously select both effective brain regions and clinical characteristics based on sparse modeling. This is in contrast to existing methods, which consider prespecified brain regions because of the computational difficulties involved in processing high-dimensional data. RBF-sPLS employs dimensionality reduction in order to overcome this obstacle. We have applied RBF-sPLS to a real dataset composed of 102 chronic kidney disease patients, while a comparison study used a simulated dataset. RBF-sPLS identified two brain regions of interest from our patient data: the temporal lobe and the occipital lobe, which are associated with aging and anemia, respectively. Our simulation study suggested that such brain regions are extracted with excellent accuracy using our method

The construction of a partial least squares biplot

Includes bibliographical references.In multivariate analysis, data matrices are often very large, which sometimes makes it difficult to describe their structure and to make a visual inspection of the relationship between their respective rows (samples) and columns (variables). For this reason, biplots, the joint graphical display of the rows and columns of a data matrix, can be useful tools for analysis. Since they were first introduced, biplots have been employed in a number of multivariate methods, such as Correspondence Analysis (CA), Principal Component Analysis (PCA), Canonical Variate Analysis (CVA) and Discriminant Analysis (DA), as a form of graphical display of data. Another possible employment is in Partial Least Squares (PLS). First introduced as a regression method, PLS is more flexible than multivariate regression, but better suited than Principal Component Regression (PCR) for the prediction of a set of response variables from a large set of predictor variables. Employing the biplot in PLS gave rise to the PLS biplot, a new addition to the biplot family. In the current study, this biplot was successfully applied to the sensory data to investigate the relationships between the sensory panel characteristics and the chemical quality measurements of sixteen olive oils. It was also applied to a large set of mineral sorting production data to investigate the relationships between the output variables and the process factors used to produce a final product. Furthermore, the PLS biplot was applied to a Binomialdistributed data concerning the diabetes testing of Indian women and to a Poisson-distributed data showing the diversity of arboreal marsupials (possum) in the Montane ash forest. After these applications, it is proposed that the PLS biplot is a useful graphical tool for displaying results from the (univariate) Partial Least Squares-Generalized Linear Model (PLS-GLM) analysis of a data set. With Partial Least Squares Regression (PLSR) being a valuable method for modelling high-dimensional data, especially in chemometrics, the PLS biplot was successfully applied to a cereal evaluation containing one hundred and forty five infrared spectra and six chemical properties, and a gene expression data with two thousand genes