The CARMENES search for exoplanets around M dwarfs: Radial-velocity variations of active stars in visual-channel spectra

Previous simulations predicted the activity-induced radial-velocity (RV) variations of M dwarfs to range from $\sim1$ cm/s to $\sim1$ km/s, depending on various stellar and activity parameters. We investigate the observed relations between RVs, stellar activity, and stellar parameters of M dwarfs by analyzing CARMENES high-resolution visual-channel spectra ($0.5$$-$$1$$\mu$m), which were taken within the CARMENES RV planet survey during its first $20$ months of operation. During this time, $287$ of the CARMENES-sample stars were observed at least five times. From each spectrum we derived a relative RV and a measure of chromospheric H$\alpha$ emission. In addition, we estimated the chromatic index (CRX) of each spectrum, which is a measure of the RV wavelength dependence. Despite having a median number of only $11$ measurements per star, we show that the RV variations of the stars with RV scatter of $>10$ m/s and a projected rotation velocity $v \sin{i}>2$ km/s are caused mainly by activity. We name these stars `active RV-loud stars' and find their occurrence to increase with spectral type: from $\sim3\%$ for early-type M dwarfs (M$0.0$$-$$2.5$V) through $\sim30\%$ for mid-type M dwarfs (M$3.0$$-$$5.5$V) to $>50\%$ for late-type M dwarfs (M$6.0$$-$$9.0$V). Their RV-scatter amplitude is found to be correlated mainly with $v \sin{i}$. For about half of the stars, we also find a linear RV$-$CRX anticorrelation, which indicates that their activity-induced RV scatter is lower at longer wavelengths. For most of them we can exclude a linear correlation between RV and H$\alpha$ emission. Our results are in agreement with simulated activity-induced RV variations in M dwarfs. The RV variations of most active RV-loud M dwarfs are likely to be caused by dark spots on their surfaces, which move in and out of view as the stars rotate.Comment: A&A accepte

Understanding stellar activity-induced radial velocity jitter using simultaneous K2 photometry and HARPS RV measurements

One of the best ways to improve our understanding of the stellar activity-induced signal in radial velocity (RV) measurements is through simultaneous high-precision photometric and RV observations. This is of prime importance to mitigate the RV signal induced by stellar activity and therefore unveil the presence of low-mass exoplanets. The K2 Campaign 7 and 8 field-of-views were located in the southern hemisphere, and provided a unique opportunity to gather unprecedented simultaneous high precision photometric observation with K2 and high-precision RV measurements with the HARPS spectrograph to study the relationship between photometric variability and RV jitter. We observed nine stars with different levels of activity; from quiet to very active. We probe the presence of any meaningful relation between measured RV jitter and the simultaneous photometric variation, and also other activity indicators (e.g. BIS, FWHM, $logR'_{HK}$, and F8), by evaluating the strength and significance of the correlation between RVs and each indicator. We found that for the case of very active stars, strong and significant correlations exist between almost all the observables and measured RVs; however, for lower activity levels the correlations become random. Except for the F8 which its strong correlation with RV jitter persists over a wide range of stellar activity level, and thus our result suggests that F8 might be a powerful proxy for activity induced RV jitter. Moreover, we examine the capability of two state-of-the-art modeling techniques, namely the FF' method and SOAP2.0, in accurately predicting the RV jitter amplitude using the simultaneous photometric observation. We found that for the very active stars both techniques can reasonably well predict the amplitude of the RV jitter, however, at lower activity levels the FF' method underpredicts the RV jitter amplitude.Comment: 13 pages, 7 figures, 2 tables, accepted for publication in A&

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs

Rotavirus 993/83, isolated from calf faeces, closely resembles an avian rotavirus

Polypeptides from purified virions of the calf rotavirus (RV) isolate 993/83 and those from the pigeon RV isolate PO-13 comigrated on SDS-polyacrylamide gels. Two polypeptides of 45K and 47K were detected at the position of VP6. Both proteins behaved like authentic VP6 protein with EDTA and heat treatment. RV 993/83 and PO-13 showed identical one-dimensional peptide maps for VP2, and the 45K and 47K proteins. More than 70% of sera from German cattle older than 1 year showed neutralizing serum antibodies to RV 993/83 and RV PO-1

Emerging role of angiogenesis in adaptive and maladaptive right ventricular remodeling in pulmonary hypertension

Right ventricular (RV) function is the primary prognostic factor for both morbidity and mortality in pulmonary hypertension (PH). RV hypertrophy is initially an adaptive physiological response to increased overload; however, with persistent and/or progressive afterload increase, this response frequently transitions to more pathological maladaptive remodeling. The mechanisms and disease processes underlying this transition are mostly unknown. Angiogenesis has recently emerged as a major modifier of RV adaptation in the setting of pressure overload. A novel paradigm has emerged that suggests that angiogenesis and angiogenic signaling are required for RV adaptation to afterload increases and that impaired and/or insufficient angiogenesis is a major driver of RV decompensation. Here, we summarize our current understanding of the concepts of maladaptive and adaptive RV remodeling, discuss the current literature on angiogenesis in the adapted and failing RV, and identify potential therapeutic approaches targeting angiogenesis in RV failure

The Bizarre Spectral Variability of Central Stars of Planetary Nebulae

A radial velocity (RV) survey to detect central stars in binary systems was carried out between 2002 and 2004. De Marco et al. (2004) reported that 10 out of 11 monitored stars exhibited strong RV variability, but periods were not detected. Since other mechanisms, such as wind variability, can cause apparent RV variations, we monitored 4 of the 10 RV-variable stars at echelle resolutions to determine the origin of the variability. Although RV changes are confirmed for all four stars, none of them can be ascribed to binarity at this time. However, only for IC4593 is wind variability able to explain most (though not all) spectral variability. For BD+332642, no wind and no pulsations appear to be the origin of the RV changes. Finally, M1-77 and M2-54, both known to be irregular photometric variables, exhibit dramatic RV and line shape variability of the hydrogen and HeI absorption lines, as well as large RV variability of weaker lines, which do not change in shape. There is no satisfactory explanation of this variability, though a combination of wind variability and pulsations is still the best guess at what makes these stars so variable. We suggest that luminous central stars are ill suited to detect spectroscopic binaries, because winds (and possibly pulsations) are pervasive and would mask even strong periodicities. It it likely that a sample of intrinsically faint central stars would more readily yield binary information.Comment: 7 pages, 3 figures. To appear in the proceedings of the conference "Asymmetric Planetary Nebulae IV

Right Heart Remodeling in Patients with End-Stage Alcoholic Liver Cirrhosis: Speckle Tracking Point of View

BACKGROUND: Data regarding cardiac remodeling in patients with alcoholic liver cirrhosis are scarce. We sought to investigate right atrial (RA) and right ventricular (RV) structure, function, and mechanics in patients with alcoholic liver cirrhosis. METHODS: This retrospective cross-sectional investigation included 67 end-stage cirrhotic patients, who were referred for evaluation for liver transplantation and 36 healthy controls. All participants underwent echocardiographic examination including strain analysis, which was performed offline. RESULTS: RV basal diameter and RV thickness were significantly higher in patients with cirrhosis. Conventional parameters of the RV systolic function were similar between the observed groups. Global, endocardial, and epicardial RV longitudinal strains were significantly lower in patients with cirrhosis. Active RA function was significantly higher in cirrhotic patients than in controls. The RA reservoir and conduit strains were significantly lower in cirrhotic patients, while there was no difference in the RA contractile strain. Early diastolic and systolic RA strain rates were significantly lower in cirrhotic patients than in controls, whereas there was no difference in the RA late diastolic strain rate between the two groups. Transaminases and bilirubin correlated negatively with RV global longitudinal strain and RV-free wall strain in patients with end-stage liver cirrhosis. The Model for End-stage Liver Disease (MELD) score, predictor of 3-month mortality, correlated with parameters of RV structure and systolic function, and RA active function in patients with end-stage liver cirrhosis. CONCLUSIONS: RA and RV remodeling is present in patients with end-stage liver cirrhosis even though RV systolic function is preserved. Liver enzymes, bilirubin, and the MELD score correlated with RV and RA remodeling

Three-dimensional echocardiography and 2D-3D speckle tracking imaging in chronic pulmonary hypertension. diagnostic accuracy in detecting hemodynamic signs of RV failure

Background and objective. Our aim was to compare three-dimensional (3D) and 2D and 3D speckle tracking (2D-STE, 3D-STE) echocardiographic parameters with conventional right ventricular (RV) indexes in patients with chronic pulmonary hypertension (PH), and investigate whether these techniques could result in better correlation with hemodynamic variables indicative of heart failure. Methods. Seventy-three adult patients (mean age, 53±13 years; 44% male) with chronic PH of different etiologies were studied by echocardiography and cardiac catheterization (25 precapillary PH from pulmonary arterial hypertension, 23 obstructive pulmonary heart disease, and 23 postcapillary PH from mitral regurgitation). Thirty healthy subjects (mean age, 54±15 years; 43% male) served as controls. Standard 2D measurements (RV-FAC -fractional area change-, TAPSE -tricuspid annular plane systolic excursion-) and mitral and tricuspid tissue Doppler annular velocities were obtained. RV 3D volumes, and global and regional ejection fraction (3D-RVEF) were determined. RV strains were calculated by 2D-STE and 3D-STE. Results. RV 3D global-free-wall longitudinal strain (3DGFW-RVLS), 2D global-free-wall longitudinal strain (GFW-RVLS), apical-free-wall longitudinal strain (AFW-RVLS), basal-free-wall longitudinal strain (BFW-RVLS), and 3D-RVEF were lower in patients with pre-capillary PH (p<0.0001) and post-capillary PH (p<0.01) compared to controls. 3DGFW-RVLS (HR 4.6, 95% CI 2.79-8.38, p=0.004) and 3D-RVEF (HR 5.3, 95% CI 2.85-9.89, p=0.002) were independent predictors of mortality. ROC curves showed that the thresholds offering an adequate compromise between sensitivity and specificity for detecting hemodynamic signs of RV failure were 39% for 3D-RVEF (AUC 0.89), -17% for 3DGFW-RVLS (AUC 0.88), -18% for GFW-RVLS (AUC 0.88), -16% for AFW-RVLS (AUC 0.85), 16mm for TAPSE (AUC 0.67), and 38% for RV-FAC (AUC 0.62). Conclusions. In chronic PH, 3D, 2D-STE and 3D-STE parameters indicate global and regional RV dysfunction that is associated with RV failure hemodynamics better than conventional echo indices