Feature Diminution by Ant Colonized Relative Reduct Algorithm for improving the Success Rate for IVF Treatment

Infertility is the most common problem faced by today’s generation. The factors like environment, genetic or personal characteristics are responsible for these problems. Different infertility treatments like IVF, IUI etc are used to treat those infertile people. But the cost and emotions beyond each and every cycle of IVF treatment is very high and also the success rate differs from person to person. So, there is a need to find a system which would predict the outcome of IVF to motivate the people both in psychologically and financially. Many Data Mining techniques are applied to predict the outcome of the IVF treatment. Reducing the unwanted features which affects the quality of result is one of the significant tasks in Data Mining. This paper proposes a hybrid algorithm named Ant Colonized Relative Reduct Algorithm (ACRRA) which combines the core features of Ant Colony Optimization Algorithm and Relative Reduct Theory for Feature Reduction. In this work, the proposed Algorithm is compared with the existing related algorithms. It is evident from the results that the proposed algorithm achieved its target of reducing the features to minimum numbers without compromising the core knowledge of the system to estimate the success rate

Pilot study on developing a decision support tool for guiding re-administration of chemotherapeutic agent after a serious adverse drug reaction

<p>Abstract</p> <p>Background</p> <p>Currently, there are no standard guidelines for recommending re-administration of a chemotherapeutic drug to a patient after a serious adverse drug reaction (ADR) incident. The decision on whether to rechallenge the patient is based on the experience of the clinician and is highly subjective. Thus the aim of this study is to develop a decision support tool to assist clinicians in this decision making process.</p> <p>Methods</p> <p>The inclusion criteria for patients in this study are: (1) had chemotherapy at National Cancer Centre Singapore between 2004 to 2009, (2) suffered from serious ADRs, and (3) were rechallenged. A total of 46 patients fulfilled the inclusion criteria. A genetic algorithm attribute selection method was used to identify clinical predictors for patients' rechallenge status. A Naïve Bayes model was then developed using 35 patients and externally validated using 11 patients.</p> <p>Results</p> <p>Eight patient attributes (age, chemotherapeutic drug, albumin level, red blood cell level, platelet level, abnormal white blood cell level, abnormal alkaline phosphatase level and abnormal alanine aminotransferase level) were identified as clinical predictors for rechallenge status of patients. The Naïve Bayes model had an AUC of 0.767 and was found to be useful for assisting clinical decision making after clinicians had identified a group of patients for rechallenge. A platform independent version and an online version of the model is available to facilitate independent validation of the model.</p> <p>Conclusion</p> <p>Due to the limited size of the validation set, a more extensive validation of the model is necessary before it can be adopted for routine clinical use. Once validated, the model can be used to assist clinicians in deciding whether to rechallenge patients by determining if their initial assessment of rechallenge status of patients is accurate.</p

Predicting Implantation Outcome from Imbalanced IVF Dataset

Abstract-Predicting implantation outcomes of invitro fertilization (IVF) embryos is critical for the success of the treatment. We have applied Naive Bayes classifier to an original IVF dataset in order to discriminate embryos according to implantation potentials. The dataset we analyzed represents an imbalanced distribution of positive and negative instances. In order to deal with the problem of imbalance, we examined the effects of over sampling the minority class, under sampling the majority class and adjustment of the decision threshold on the classification performance. We have used features of Receiver Operating Characteristics (ROC) curves in the evaluation of experiments. Our results revealed that it is possible to obtain optimum True Positive and False Positive Rates simply by adjusting the decision threshold. Under-sampling experiments show that we can achieve same prediction performance with less data as well as 736 embryo samples

Enhancing Software Project Outcomes: Using Machine Learning and Open Source Data to Employ Software Project Performance Determinants

Many factors can influence the ongoing management and execution of technology projects. Some of these elements are known a priori during the project planning phase. Others require real-time data gathering and analysis throughout the lifetime of a project. These real-time project data elements are often neglected, misclassified, or otherwise misinterpreted during the project execution phase resulting in increased risk of delays, quality issues, and missed business opportunities. The overarching motivation for this research endeavor is to offer reliable improvements in software technology management and delivery. The primary purpose is to discover and analyze the impact, role, and level of influence of various project related data on the ongoing management of technology projects. The study leverages open source data regarding software performance attributes. The goal is to temper the subjectivity currently used by project managers (PMs) with quantifiable measures when assessing project execution progress. Modern-day PMs who manage software development projects are charged with an arduous task. Often, they obtain their inputs from technical leads who tend to be significantly more technical. When assessing software projects, PMs perform their role subject to the limitations of their capabilities and competencies. PMs are required to contend with the stresses of the business environment, the policies, and procedures dictated by their organizations, and resource constraints. The second purpose of this research study is to propose methods by which conventional project assessment processes can be enhanced using quantitative methods that utilize real-time project execution data. Transferability of academic research to industry application is specifically addressed vis-à-vis a delivery framework to provide meaningful data to industry practitioners