Neutron/proton ratio of nucleon emissions as a probe of neutron skin

The dependence between neutron-to-proton yield ratio ($R_{np}$) and neutron skin thickness ($\delta_{np}$) in neutron-rich projectile induced reactions is investigated within the framework of the Isospin-Dependent Quantum Molecular Dynamics (IQMD) model. The density distribution of the Droplet model is embedded in the initialization of the neutron and proton densities in the present IQMD model. By adjusting the diffuseness parameter of neutron density in the Droplet model for the projectile, the relationship between the neutron skin thickness and the corresponding $R_{np}$ in the collisions is obtained. The results show strong linear correlation between $R_{np}$ and $\delta_{np}$ for neutron-rich Ca and Ni isotopes. It is suggested that $R_{np}$ may be used as an experimental observable to extract $\delta_{np}$ for neutron-rich nuclei, which is very significant to the study of the nuclear structure of exotic nuclei and the equation of state (EOS) of asymmetric nuclear matter.Comment: 7 pages, 5 figures; accepted by Phys. Lett.

Neutron-loaded outflows in gamma-ray bursts

Relativistic neutron-loaded outflows in gamma-ray bursts are studied at their early stages, before deceleration by a surrounding medium. The outflow has four components: radiation, electrons, protons and neutrons. The components interact with each other and exchange energy as the outflow expands. The presence of neutrons significantly changes the outflow evolution. Before neutrons decouple from protons, friction between the two components increases their temperatures by many orders of magnitude. After the decoupling, the gradual neutron decay inside the outflow has a drag effect on the protons and reduces their final Lorentz factor.Comment: 11 pages, 9 figures, submitted to MNRAS EMR current affiliation: JILA, UC at Boulde

An Analytical Framework to Describe the Interactions Between Individuals and a Continuum

We consider a discrete set of individual agents interacting with a continuum. Examples might be a predator facing a huge group of preys, or a few shepherd dogs driving a herd of sheeps. Analytically, these situations can be described through a system of ordinary differential equations coupled with a scalar conservation law in several space dimensions. This paper provides a complete well posedness theory for the resulting Cauchy problem. A few applications are considered in detail and numerical integrations are provided

Dysregulation of H/ACA ribonucleoprotein components in chronic lymphocytic leukemia

Telomeres are protective repeats of TTAGGG sequences located at the end of human chromosomes. They are essential to maintain chromosomal integrity and genome stability. Telomerase is a ribonucleoprotein complex containing an internal RNA template (hTR) and a catalytic subunit (hTERT). The human hTR gene consists of three major domains; among them the H/ACA domain is essential for telomere biogenesis. H/ACA ribonucleoprotein (RNP) complex is composed of four evolutionary conserved proteins, including dyskerin (encoded by DKC1 gene), NOP10, NHP2 and GAR1. In this study, we have evaluated the expression profile of the H/ACA RNP complex genes: DKC1, NOP10, NHP2 and GAR1, as well as hTERT and hTR mRNA levels, in patients with chronic lymphocytic leukemia (CLL). Results were correlated with the number and type of genetic alteration detected by conventional cytogenetics and FISH (fluorescence in situ hybridization), IGHV (immunoglobulin heavy chain variable region) mutational status, telomere length (TL) and clinico pathological characteristics of patients. Our results showed significant decreased expression of GAR1, NOP10, DKC1 and hTR, as well as increased mRNA levels of hTERT in patients compared to controls (p=0.04). A positive correlation between the expression of GAR1-NHP2, GAR1-NOP10, and NOP10-NHP2 (p=0.0001), were observed. The analysis taking into account prognostic factors showed a significant increased expression of hTERT gene in unmutated-IGHV cases compared to mutated-CLL patients (p = 0.0185). The comparisons among FISH groups exhibited increased expression of DKC1 in cases with two or more alterations with respect to no abnormalities, trisomy 12 and del13q14, and of NHP2 and NOP10 compared to those with del13q14 (p = 0.03). The analysis according to TL showed a significant increased expression of hTERT (p = 0.0074) and DKC1 (p = 0.0036) in patients with short telomeres compared to those with long TL. No association between gene expression and clinical parameters was found. Our results suggest a role for these telomere associated genes in genomic instability and telomere dysfunction in CLL.Fil: Dos Santos, Patricia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Panero, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Stanganelli, Carmen Graciela. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFil: Palau Nagore, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Stella, Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Bezares, Raimundo F.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; ArgentinaFil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentin

Influence of complex configurations on properties of pygmy dipole resonance in neutron-rich Ca isotopes

Starting from the quasiparticle random phase approximation based on the Skyrme interaction SLy5, we study the effects of phonon-phonon coupling~(PPC) on the low-energy electric dipole response in $^{40-58}$Ca. Using the same set of parameters we describe available experimental data for $^{40,44,48}$Ca and give prediction for $^{50-58}$Ca. The inclusion of the PPC results in the formation of low-energy $1^-$ states. There is an impact of the PPC effect on low-energy $E1$~strength of $^{40,44,48}$Ca. The PPC effect on the electric dipole polarizability is discussed. We predict a strong increase of the summed $E1$~strength below 10MeV, with increasing neutron number from $^{48}$Ca till $^{58}$Ca.Comment: 11 pages, 10 figure

Relativistic Brueckner-Hartree-Fock theory for neutron drops

Neutron drops confined in an external field are studied in the framework of relativistic Brueckner-Hartree-Fock theory using the bare nucleon-nucleon interaction. The ground state energies and radii of neutron drops with even numbers from $N = 4$ to $N=50$ are calculated and compared with results obtained from other nonrelativistic \textit{ab initio} calculations and from relativistic density functional theory. Special attention has been paid to the magic numbers and to the sub-shell closures. The single-particle energies are investigated and the monopole effect of the tensor force on the evolutions of the spin-orbit and the pseudospin-orbit splittings is discussed. The results provide interesting insight of neutron rich systems and can form an important guide for future density functionals.Comment: 31 pages, 12 figure

Cell division promotes efficient retrotransposition in a stable L1 reporter cell line

Background: Long interspersed element type one (L1) actively modifies the human genome by inserting new copies of itself. This process, termed retrotransposition, requires the formation of an L1 ribonucleoprotein (RNP) complex, which must enter the nucleus before retrotransposition can proceed. Thus, the nuclear import of L1 RNP presents an opportunity for cells to regulate L1 retrotransposition post-translationally. The effect of cell division on L1 retrotransposition has been investigated by two previous studies, which observed varied degrees of inhibition in retrotransposition when primary cell strains or cancer cell lines were experimentally arrested in different stages of the cell cycle. However, seemingly divergent conclusions were reached. The role of cell division on retrotransposition remains highly debated. Findings: To monitor both L1 expression and retrotransposition quantitatively, we developed a stable dual-luciferase L1 reporter cell line, in which a bi-directional tetracycline-inducible promoter drives the expression of both a firefly luciferase-tagged L1 element and a Renilla luciferase, the latter indicative of the level of promoter induction. We observed an additional 10-fold reduction in retrotransposition in cell-cycle arrested cells even after retrotransposition had been normalized to Renilla luciferase or L1 ORF1 protein levels. In synchronized cells, cells undergoing two mitoses showed 2.6-fold higher retrotransposition than those undergoing one mitosis although L1 expression was induced for the same amount of time. Conclusions: Our data provide additional support for an important role of cell division in retrotransposition and argue that restricting the accessibility of L1 RNP to nuclear DNA could be a post-translational regulatory mechanism for retrotransposition