2,702 research outputs found

    Nanomechanical single-photon routing

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    The merger between integrated photonics and quantum optics promises new opportunities within photonic quantum technology with the very significant progress on excellent photon-emitter interfaces and advanced optical circuits. A key missing functionality is rapid circuitry reconfigurability that ultimately does not introduce loss or emitter decoherence, and operating at a speed matching the photon generation and quantum memory storage time of the on-chip quantum emitter. This ambitious goal requires entirely new active quantum-photonic devices by extending the traditional approaches to reconfigurability. Here, by merging nano-optomechanics and deterministic photon-emitter interfaces we demonstrate on-chip single-photon routing with low loss, small device footprint, and an intrinsic time response approaching the spin coherence time of solid-state quantum emitters. The device is an essential building block for constructing advanced quantum photonic architectures on-chip, towards, e.g., coherent multi-photon sources, deterministic photon-photon quantum gates, quantum repeater nodes, or scalable quantum networks.Comment: 7 pages, 3 figures, supplementary informatio

    NASA SBIR abstracts of 1990 phase 1 projects

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    The research objectives of the 280 projects placed under contract in the National Aeronautics and Space Administration (NASA) 1990 Small Business Innovation Research (SBIR) Phase 1 program are described. The basic document consists of edited, non-proprietary abstracts of the winning proposals submitted by small businesses in response to NASA's 1990 SBIR Phase 1 Program Solicitation. The abstracts are presented under the 15 technical topics within which Phase 1 proposals were solicited. Each project was assigned a sequential identifying number from 001 to 280, in order of its appearance in the body of the report. The document also includes Appendixes to provide additional information about the SBIR program and permit cross-reference in the 1990 Phase 1 projects by company name, location by state, principal investigator, NASA field center responsible for management of each project, and NASA contract number

    Principles of Neuromorphic Photonics

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    In an age overrun with information, the ability to process reams of data has become crucial. The demand for data will continue to grow as smart gadgets multiply and become increasingly integrated into our daily lives. Next-generation industries in artificial intelligence services and high-performance computing are so far supported by microelectronic platforms. These data-intensive enterprises rely on continual improvements in hardware. Their prospects are running up against a stark reality: conventional one-size-fits-all solutions offered by digital electronics can no longer satisfy this need, as Moore's law (exponential hardware scaling), interconnection density, and the von Neumann architecture reach their limits. With its superior speed and reconfigurability, analog photonics can provide some relief to these problems; however, complex applications of analog photonics have remained largely unexplored due to the absence of a robust photonic integration industry. Recently, the landscape for commercially-manufacturable photonic chips has been changing rapidly and now promises to achieve economies of scale previously enjoyed solely by microelectronics. The scientific community has set out to build bridges between the domains of photonic device physics and neural networks, giving rise to the field of \emph{neuromorphic photonics}. This article reviews the recent progress in integrated neuromorphic photonics. We provide an overview of neuromorphic computing, discuss the associated technology (microelectronic and photonic) platforms and compare their metric performance. We discuss photonic neural network approaches and challenges for integrated neuromorphic photonic processors while providing an in-depth description of photonic neurons and a candidate interconnection architecture. We conclude with a future outlook of neuro-inspired photonic processing.Comment: 28 pages, 19 figure

    Graphene-Based Acousto-Optic Sensors with Vibrating Resonance Energy Transfer and Applications

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    Graphene as a two-dimensional planar material has numerous advantages for realizing high-performance nano-electromechanical systems (NEMS) such as nanoscale sensors including strain sensors, optical modulators or energy harvesters. Large Young’s modulus (1 TPa for single layer graphene), ultra-low weight, low residual stress and large breaking strength properties are important properties as two-dimensional (2D) ultrathin resonators. Graphene resonators are recently utilized for low complexity design of nanoscale acousto-optic sensors based on a novel theoretical model describing vibrating Förster resonance energy transfer (VFRET) mechanism. Proposed system combines the advantages of graphene with quantum dots (QDs) as donor and acceptor pairs with broad absorption spectrum, large cross-sections, tunable emission spectra, size-dependent emission wavelength, high photochemical stability and improved quantum yield. Device structure supporting wide-band resonance frequencies including acoustic and ultrasound ranges promises high-performance applications for challenging environments. Remote sensors and acousto-optic communication channels are formed for in-body applications, wireless body area sensor networks (WBASNs), space and interplanetary systems, microfluidics and visible light communication (VLC)-based architectures

    Development of a three-dimensional microphysiological Retina-on-a-Chip system

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    The human retina is a complex neurosensory system that features multiple layers of different retinal neurons. Those neurons are arranged in a unique architecture and function to transmit a signal to the human brain that is interpreted as visual perception. Vision impairment is affecting millions of people worldwide while at the same time, for many disorders, pharmacological treatment options are not available or can only ameliorate the symptoms. To be able to investigate underlying disease mechanisms and to find new pharmacologic treatment options, new retina models are urgently required. Up to now, there are several different retinal model systems available, ranging from animal models to in silico as well as in vitro cell culture models. These systems differ considerably in their advantages and applicability. However, the limitations of each system lead to the consequence that a new and physiological accurate model system is necessary that is able to represent the human retina biology with all of its cell types as precisely as possible. Retinal organoids (ROs) as miniature “retina in a dish” have the potential to serve as new in vitro model system. They feature all retinal layers, can be generated from healthy human cells but also from patient material. Here especially, they can serve as disease model and allow to test potential treatment options. However, standard dish culture of these organoids leads to several limitations since the tissues’ natural environment is not considered. This thesis substantially contributed to the development of a new microfluidic retina-on-a-chip (RoC) system. For this purpose, we combined RO-technology with organ-on-a-chip technology (OoC). OoC technology uses microfluidic devices for cell-culture to simulate an organ-like physiology. We used ROs as well as retinal pigment epithelium (RPE) cells derived from human induced pluripotent stem cells by retinal differentiation to integrate them into a microfluidic chip system. By first establishing individual culture chips for monoculture of RPE or ROs alone, we verified that both tissues are viable and can be cultured in the chip environment. Using immunohistochemistry and qRT-PCR we showed that characteristic markers expression is not affected and using electron microscopy that the typical morphology is preserved. The chips were then combined into a co-culture RoC system, enabling the cultivation of ROs in close contact with RPE cells. We verified that it was possible to bring both tissues into a physiological and close contact by analyzing the distance between RPE and RO inside the chip using live-cell imaging and immunohistochemistry. Further, we found that the setup inside the RoC leads to improved segment formation in the photoreceptors of the ROs. This was shown in a qualitative fashion using immunohistochemistry and also in a quantitative fashion, using electron microscopic comparisons between dish-cultured and chip-cultured ROs. In this context, we also observed a positive impact of the presence of RPE inside the chip regarding photoreceptor segment formation. As another functionality test to show a physiological setup, we analyzed the phagocytotic ability of the RPE cells for digestions of shed photoreceptors segments inside the RoC. Using live-cell imaging, immunohistochemistry and electron microscopy, we were able to confirm phagocytosis inside the RPE layer within the RoC. Lastly, as a proof-of-principle study, we showed that the RoC is suitable as an in vitro drug-testing device for analysis of retinal toxicity. The known retinopathic effect of two different drugs, chloroquine and gentamicin, was verified by analyzing cell death with live-cell imaging of treated RoCs and subsequent quantitative comparison to non-treated RoCs. In the case of chloroquine, also the known lysosomotropic effect was verified using immunohistochemistry. In summary, we have generated a new and physiological microfluidic retina-on-a-chip system that helps to improve RO generation and maturation. This system represents a new retinal model system and is suitable not only for testing of candidate or established drugs regarding retinal toxicity, but it has the outmost potential to serve as a disease model to identify new pharmacological treatment options as well as underlying disease mechanisms
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