Automatic Parameterization of the Purine Metabolism Pathway through Discrete Event-based Simulation

Model development and analysis of metabolic networks is recognized as a key requirement for integrating in-vitro and in-vivo experimental data. In-silico simulation of a biochemical model allows one to test different experimental conditions, helping in the discovery of the dynamics that regulate the system. Although qualitative characterizations of such complex mechanisms are, at least partially, available, a fully-parametrized quantitative description is often miss- ing. On the other hand, several characteristics and issues to model biological systems are common to the electronics system modelling, such as concurrency, reactivity, abstraction levels, automatic reverse engineering, as well as design space explosion during validation. This work presents a methodology that applies languages, techniques, and tools well established in the context of electronic design automation (EDA) for modelling and simulation of metabolic networks through Petri nets. The paper presents the results obtained by applying the proposed methodology to model the purine metabolism starting from the metabolomics data obtained from naive lymphocytes and autoreactive T cells implicated in the induction of experimental autoimmune disorders

On Modeling and Analyzing Cost Factors in Information Systems Engineering

Introducing enterprise information systems (EIS) is usually associated with high costs. It is therefore crucial to understand those factors that determine or influence these costs. Though software cost estimation has received considerable attention during the last decades, it is difficult to apply existing approaches to EIS. This difficulty particularly stems from the inability of these methods to deal with the dynamic interactions of the many technological, organizational and projectdriven cost factors which specifically arise in the context of EIS. Picking up this problem, we introduce the EcoPOST framework to investigate the complex cost structures of EIS engineering projects through qualitative cost evaluation models. This paper extends previously described concepts and introduces design rules and guidelines for cost evaluation models in order to enhance the development of meaningful and useful EcoPOST cost evaluation models. A case study illustrates the benefits of our approach. Most important, our EcoPOST framework is an important tool supporting EIS engineers in gaining a better understanding of the critical factors determining the costs of EIS engineering projects

Automatic construction of rules fuzzy for modelling and prediction of the central nervous system

The main goal of this work is to study the performance of CARFIR (Automatic Construction of Rules in Fuzzy Inductive Reasoning) methodology for the modelling and prediction of the human central nervous system (CNS). The CNS controls the hemodynamical system by generating the regulating signals for the blood vessels and the heart. The main idea behind CARFIR is to expand the capacity of the FIR methodology allowing it to work with classical fuzzy rules. CARFIR is able to automatically construct fuzzy rules starting from a set of pattern rules obtained by FIR. The new methodology preserves as much as possible the knowledge of the pattern rules in a compact fuzzy rule base. The prediction results obtained by the fuzzy prediction process of CARFIR methodology are compared with those of other inductive methodologies, i.e. FIR, NARMAX and neural networksPostprint (published version

Modeling an ontology on accessible evacuation routes for emergencies

Providing alert communication in emergency situations is vital to reduce the number of victims. However, this is a challenging goal for researchers and professionals due to the diverse pool of prospective users, e.g. people with disabilities as well as other vulnerable groups. Moreover, in the event of an emergency situation, many people could become vulnerable because of exceptional circumstances such as stress, an unknown environment or even visual impairment (e.g. fire causing smoke). Within this scope, a crucial activity is to notify affected people about safe places and available evacuation routes. In order to address this need, we propose to extend an ontology, called SEMA4A (Simple EMergency Alert 4 [for] All), developed in a previous work for managing knowledge about accessibility guidelines, emergency situations and communication technologies. In this paper, we introduce a semi-automatic technique for knowledge acquisition and modeling on accessible evacuation routes. We introduce a use case to show applications of the ontology and conclude with an evaluation involving several experts in evacuation procedures. © 2014 Elsevier Ltd. All rights reserved