788 research outputs found
2023-2024 Catalog
The 2023-2024 Governors State University Undergraduate and Graduate Catalog is a comprehensive listing of current information regarding:Degree RequirementsCourse OfferingsUndergraduate and Graduate Rules and Regulation
Parental risk and resilience: How does evidence inform child maltreatment prevention and reduction?
Child Maltreatment is a global concern with a sequela of negative consequences. The Risk and Resilience Ecological Framework is used to enable synthesis of evidence from two systematic reviews, A and B, on evidence of factors that influence parental child maltreatment. Review A comprises non-interventional, empirical studies to determine parental risk and protective factor interplay, lending support to causal and correlational links to child maltreatment. Review B synthesises evidence from intervention evaluations on parental risk factors and intervention provision for child maltreatment. A total of 128 studies, 68 observational studies in Review A and 60 intervention evaluations in Review B, were systematically reviewed. Quality appraisal did not lead to exclusion of studies. Review A findings mirror prior evidence and highlight nuances such as memories of parental childhood maltreatment as risk, emotional support for mothers and companionship support for fathers as protective, and demarcate maltreatment type-specific factors, especially for physical abuse and neglect. A low representation of fathers, under-research of unique factors for sexual and emotional abuse and of macro-level protective factors were identified. Review B provides comprehensive data on potentially effective intervention components including child development education and parental emotional regulation. Behaviour Change Techniques Framework helped identify potentially optimal delivery techniques including Instruction on how to perform a behaviour and Social support (unspecified). Lack of cultural representation, sparsity of interventions targeting fathers, over-reliance on self-reporting measures and under-examination of macro-level intervention components were identified as gaps in knowledge. Both reviews underline a call for consensus in definitions and avoidance of umbrella terms. A final synthesis elucidated the complex interplay of multiple influences on parental child maltreatment. Findings offer valuable insight to move the field forward, inform researchers, policy, and practice to strengthen parental resilience to prevent and reduce child maltreatment
SOC ATTACKER CENTRIC - Analysis of a prevention oriented SOC
This thesis will explain what a Security Operation Center (SOC) is and how it works,
analyzing all the different phases and modules that make up the final product. Typically,
a SOC centralizes all of the company’s information in one place where it can
constantly keep an eye on the data and monitor the system. The IT infrastructure
is analyzed in real time for anomalies, malicious activities, or intrusion attempts.
Not only the data sent from one machine to another, but also the physical state
and resources (e.g., memory and CPU) are constantly monitored. Through the creation
and use of multiple detection rules, various alerts are generated and are then
reviewed by the SOC analyst team, which promptly informs customers in case of
need.
The State of the Art will be explored to study current SOCs and best practices
adopted. Then the innovative SOC Attacker Centric developed by the company
Wuerth Phoenix will be analyzed. The functioning of the SOC-AC will be studied
and explained, highlighting how it adds to the classic suite of services offered by a
SOC an extra part, focused on the attacker’s point of view. This SOC-AC is capable
of covering the reconnaissance phase, usually neglected by SOCs, in which attackers
gather information about a target in order to find the best strategy to break in and
successfully carry out the attack.
In the last part of the thesis, the design and implementation of an automatic SOC
reporting functionality will be shown. An important feature is to have an efficient
communication channel with the customer and to provide them with data on the
status of the SOC they are paying for. Initially, this procedure was a static, manually
executed, error-prone process. The procedure was improved by creating a
semi-automatic system of report generation and delivery using the Elastic SIEM
and several languages such as python, bash, Lucene, Elastic, and Kibana Query
Languages, leaving the reporter with fewer parts to analyze and document, saving
time and resources
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Investigation of the clinical utility of two potential pro-oncogenic genes in prostate cancer and breast cancer
The Identification of novel and specific biomarkers is crucial to diagnosis, and prognosis, in patients with prostate and breast cancer. Because cancer therapies have side effects in patients, discovering and potentially targeting specific biomarkers could promote the use of personalised approach for a more effective treatment.
Firstly, we have focused on the development of a monoclonal antibody-drug-based therapy, targeting prostate cancer stem cells (PCSCs), using a monoclonal antibody (mAb) previously generated in our laboratory against human endothelial protein C receptor (EPCR). PCSCs were isolated using lentivirus expressing the enhanced green fluorescent protein (EGFP) under NANOG-promoter generating two populations NANOG-EGFP+ and NANOG-EGFP- and analysed for EPCR expression.
No significant difference was observed in the expression of EPCR between NANOG-EGFP+ and NANOGEGFP- cell populations. A lack of conclusive correlation was observed between EPCR deficient cells with epithelial-mesenchymal transition (EMT) markers, cancer stem cells (CSCs), and stem cell markers. Finally, Gene Expression Profiling Interactive Analysis (GEPIA) was used to look at the tissue expression in normal and tumour tissue, showing high expression of EPCR in endothelial cells. Finally, based tissue expression profiling, EPCR is not a suitable candidate for antibody targeting as it would lead to off-target effects in multiple tissues, therefore no further experiments were designed using EPCR as a target biomarker.
Following this, a feasible study on the effect of Sperm-Associated Antigen 5 (SPAG5) chemoresistance and cancer progression in prostate and breast cancer was performed. The transcriptome and proteome of SPAG5 deficient were investigated in triple-negative breast cancer (TBC) MDA-MB-231 and androgenindependent prostate cancer DU145 cell lines, by RNA-sequencing and mass spectrometry (MS) analysis. Transcriptome was performed and a total of 2,201 differentially expressed genes (DEGs) in MDA-MB-231 SPAG5 deficient cells, while 907 DEGs DU145 SPAG5 deficient cells, versus control empty vector pLKO.1 cells, were identified. No significant differences in the cell cycle were observed in Doxorubicin and Epirubicin treatment DU145 and MDA-MB-231 SPAG5 deficient cells versus controls.
A list of the most statistically significant genes upregulated and downregulated was taken forward for verification for common and unique pathways, through free available online resources such as METASCAPE, and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO). Using StatsPro free online sources proteomics analysis generated 230 differentially expressed proteins (DEPs) in MDA-MB- 231 SPAG5 deficient cells and 65 DEPs DU145 SPAG5 deficient versus control cells. Protein-protein interaction (PPI) network using Cytoscape has been conducted for enrichment KEGG analysis.
Cross-over data from MS and RNAseq upregulated and downregulated genes in MDA-MB-231 and DU145 SPAG5 deficient were compared to in silico data from cBioPortal tool. Interestingly, positive correlation was observed in genes involved in cell cycle, but also in genes involved in catalyse and biosynthesis of cholesterol.
Collectively those data offer a wider insight into the association of SPAG5 in cancer progression and its potential role not only in pathways involved in cell cycle but also how in lipid metabolism in cancer
A multiple method approach: case studies of multiple nongovernmental development organisations in Zambia
The delivery of community-based international development programmes by local nongovernmental organisations in Zambia is now reaching the third generation of young people. Many of the first generation of children, once participants of community programmes, now manage the implementation process of those programmes. This sector integrates sport with programme delivery in Zambia to advance the life prospects of young people. In this field of sport and international development the development practices within local nongovernmental organisations in Zambia has received limited attention in research. The aim of this research is to explore the practices of development underway within these local nongovernmental organisations in Zambia.
The perspectives of development as freedom and capability and humanness and personhood inform the approach taken by this research to explore local development activities and practices. These perspectives are understood from wider international development literature (Sen, 1999; Hoffmann and Metz, 2017) and emergent literature in the field of sport and international development (Svensson and Levine, 2017; Mwaanga and Adeosun, 2020). Sen (1999) offers this research the lens of poverty as depriving people of what they would otherwise have the capability to achieve while Hoffmann and Metz (2017) offer a series of virtues one must exercise to qualify as an ethical being according to the perspective of humanness and personhood which is otherwise known as African ubuntu philosophy. Svensson and Levine (2017) enable the research to frame development activity that uses sport and physical activity according to the capability approach while Makuku’s (2013) analysis of Shalapo Canicandala, a well-known novel by Simon Mwansa Kapwepwe (1967), effectively lists ubuntu values long practiced by indigenous tribespeople of Zambia which this research applies to explore findings.
The research used a qualitative approach to gather empirical data about local development practitioners’ experiences working for local nongovernmental organisaitons in Zambia. Data were mainly collected from one round of interviews with 15 development practitoners. Further data were gathered by engaging local practitioners in creative methods of creative writing, photography, and voice recordings. Interviews were interpreted with thematic analysis with trustworthiness achieved through membeing checking.
The findings suggest that local development practitioners believe local nongovernmental organisations promote community development effectively and that they do so through a wide range of activities and processes which enable such promotion of community development. The research findings are presented as activities participants listed as essential to their organisations function which in general terms included organisation background, programmes, programme design and implementation, leadership, partnerships, Covid-19, and international voltuneering. Thematic analysis of findings prompted a discussion of precise themes featuring within these organisaiton functions as follows: international volunteers (religion, family values, dress codes, child safeguarding, problem-solving), organisation partnerships (community schools, government departments, universities, sporting bodies), programme design (Sport in Aciton, NOWSPAR, Response Network), programme implementation (dignity, feminism, civic/political leaders, life skills development), traditional games (HIV/AIDS education, male patriarchy, declining interest), social enterprise activity (Covid-19 as catalyst, Zoca, income generation, opportunities to value), international partnerships (independent female choice, social change and knowledge exchange, potential for social change, competing values), and organisation communications (transparent internal communications, effective stakeholder communication, independent stakeholder communication).
The original contributions made by this thesis to knowledge include contributions to theory, methodology, context, and practice. It contributes to theory development by applying the development as freedom and capability and development as humanness and personhood perspective to empirical findings drawn from community development activities underway in the context of Zambia. The thesis offers a contribution to methodology by applying creative methods like creative writing, photography, and voice recording which align with perspectives offered by postcoloinial theorists of development. An original contribution is made to context with the research gathering rich empirical data relevant to the national context of Zambia, the context of the local nongovernment organisations explored as case by the thesis, and community contexts where these organisations work. Finally, the thesis contributes to practice with nuanced understandings of development stakeholders involved in partnership working in the sport and international development sector of Zambia
Unified System on Chip RESTAPI Service (USOCRS)
Abstract. This thesis investigates the development of a Unified System on Chip RESTAPI Service (USOCRS) to enhance the efficiency and effectiveness of SOC verification reporting. The research aims to overcome the challenges associated with the transfer, utilization, and interpretation of SoC verification reports by creating a unified platform that integrates various tools and technologies.
The research methodology used in this study follows a design science approach. A thorough literature review was conducted to explore existing approaches and technologies related to SOC verification reporting, automation, data visualization, and API development. The review revealed gaps in the current state of the field, providing a basis for further investigation. Using the insights gained from the literature review, a system design and implementation plan were developed. This plan makes use of cutting-edge technologies such as FASTAPI, SQL and NoSQL databases, Azure Active Directory for authentication, and Cloud services. The Verification Toolbox was employed to validate SoC reports based on the organization’s standards. The system went through manual testing, and user satisfaction was evaluated to ensure its functionality and usability.
The results of this study demonstrate the successful design and implementation of the USOCRS, offering SOC engineers a unified and secure platform for uploading, validating, storing, and retrieving verification reports. The USOCRS facilitates seamless communication between users and the API, granting easy access to vital information including successes, failures, and test coverage derived from submitted SoC verification reports. By automating and standardizing the SOC verification reporting process, the USOCRS eliminates manual and repetitive tasks usually done by developers, thereby enhancing productivity, and establishing a robust and reliable framework for report storage and retrieval. Through the integration of diverse tools and technologies, the USOCRS presents a comprehensive solution that adheres to the required specifications of the SOC schema used within the organization.
Furthermore, the USOCRS significantly improves the efficiency and effectiveness of SOC verification reporting. It facilitates the submission process, reduces latency through optimized data storage, and enables meaningful extraction and analysis of report data
Medical devices with embedded electronics: design and development methodology for start-ups
358 p.El sector de la biotecnología demanda innovación constante para hacer frente a los retos del sector sanitario. Hechos como la reciente pandemia COVID-19, el envejecimiento de la población, el aumento de las tasas de dependencia o la necesidad de promover la asistencia sanitaria personalizada tanto en entorno hospitalario como domiciliario, ponen de manifiesto la necesidad de desarrollar dispositivos médicos de monitorización y diagnostico cada vez más sofisticados, fiables y conectados de forma rápida y eficaz. En este escenario, los sistemas embebidos se han convertido en tecnología clave para el diseño de soluciones innovadoras de bajo coste y de forma rápida. Conscientes de la oportunidad que existe en el sector, cada vez son más las denominadas "biotech start-ups" las que se embarcan en el negocio de los dispositivos médicos. Pese a tener grandes ideas y soluciones técnicas, muchas terminan fracasando por desconocimiento del sector sanitario y de los requisitos regulatorios que se deben cumplir. La gran cantidad de requisitos técnicos y regulatorios hace que sea necesario disponer de una metodología procedimental para ejecutar dichos desarrollos. Por ello, esta tesis define y valida una metodología para el diseño y desarrollo de dispositivos médicos embebidos
Hands-on Science. Celebrating Science and Science Education
The book herein aims to contribute to the improvement of Science Education in our schools and to an effective implementation of a sound widespread scientific literacy at all levels of society
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