10,209 research outputs found
Predicting Slice-to-Volume Transformation in Presence of Arbitrary Subject Motion
This paper aims to solve a fundamental problem in intensity-based 2D/3D
registration, which concerns the limited capture range and need for very good
initialization of state-of-the-art image registration methods. We propose a
regression approach that learns to predict rotation and translations of
arbitrary 2D image slices from 3D volumes, with respect to a learned canonical
atlas co-ordinate system. To this end, we utilize Convolutional Neural Networks
(CNNs) to learn the highly complex regression function that maps 2D image
slices into their correct position and orientation in 3D space. Our approach is
attractive in challenging imaging scenarios, where significant subject motion
complicates reconstruction performance of 3D volumes from 2D slice data. We
extensively evaluate the effectiveness of our approach quantitatively on
simulated MRI brain data with extreme random motion. We further demonstrate
qualitative results on fetal MRI where our method is integrated into a full
reconstruction and motion compensation pipeline. With our CNN regression
approach we obtain an average prediction error of 7mm on simulated data, and
convincing reconstruction quality of images of very young fetuses where
previous methods fail. We further discuss applications to Computed Tomography
and X-ray projections. Our approach is a general solution to the 2D/3D
initialization problem. It is computationally efficient, with prediction times
per slice of a few milliseconds, making it suitable for real-time scenarios.Comment: 8 pages, 4 figures, 6 pages supplemental material, currently under
review for MICCAI 201
Low temperature dynamics of kinks on Ising interfaces
The anisotropic motion of an interface driven by its intrinsic curvature or
by an external field is investigated in the context of the kinetic Ising model
in both two and three dimensions. We derive in two dimensions (2d) a continuum
evolution equation for the density of kinks by a time-dependent and nonlocal
mapping to the asymmetric exclusion process. Whereas kinks execute random walks
biased by the external field and pile up vertically on the physical 2d lattice,
then execute hard-core biased random walks on a transformed 1d lattice. Their
density obeys a nonlinear diffusion equation which can be transformed into the
standard expression for the interface velocity v = M[(gamma + gamma'')kappa +
H]$, where M, gamma + gamma'', and kappa are the interface mobility, stiffness,
and curvature, respectively. In 3d, we obtain the velocity of a curved
interface near the orientation from an analysis of the self-similar
evolution of 2d shrinking terraces. We show that this velocity is consistent
with the one predicted from the 3d tensorial generalization of the law for
anisotropic curvature-driven motion. In this generalization, both the interface
stiffness tensor and the curvature tensor are singular at the
orientation. However, their product, which determines the interface velocity,
is smooth. In addition, we illustrate how this kink-based kinetic description
provides a useful framework for studying more complex situations by modeling
the effect of immobile dilute impurities.Comment: 11 pages, 10 figure
Role of computed tomography and magnetic resonance imaging in patients with cardiovascular disease
Background: Although there have been recent advances, cardiovascular disease remains the commonest cause of premature death in the United Kingdom. There is a need to develop safe non-invasive techniques to aid the diagnosis and treatment of patients with cardiovascular disease.Objectives: The aims of this thesis are: (i) to establish whether coronary artery calcification can be measured reproducibly by helical computed tomography; (ii) to establish the effect of lipid lowering therapy on the progression of coronary calcification; (iii) to determine whether multidetector computed tomography can predict graft patency in patients who have undergone coronary artery bypass grafting; and (iv), to investigate the role of magnetic resonance imaging to assess plaque characteristics following acute carotid plaque rupture.Methods: In 16 patients, coronary artery calcification was assessed twice within 4 weeks by helical computed tomography. As part of a randomised controlled trial, patients received atorvastatin 80 mg daily or matching placebo, and had coronary calcification assessed annually. Fifty patients with previous coronary artery bypass surgery who were listed for diagnostic coronary angiography underwent contrast enhanced computed tomography angiography using a 16-slice multidetector computed tomography scanner. Finally, 15 patients with recent symptoms and signs of an acute transient ischaemic attack, amaurosis fugax or stroke underwent magnetic resonance angiography of the carotid arteries using dedicated surface coils. Plaque volume, regional plaque densities and neovascularisation were determined before and after gadolinium enhancement.Results: Quantification of coronary artery calcification demonstrated good reproducibility in patients with scores > 100 AU. Despite reducing systemic inflammation and halving serum low-density lipoprotein cholesterol concentrations, atorvastatin therapy did not affect the rate of progression of coronary artery calcification. Computed tomography angiography was found to be highly specific for the detection of graft patency. Assessment of plaque characteristics by magnetic resonance scanning in patients with recent acute carotid plaque was feasible and reproducible.Conclusions: Coronary artery calcium scores can be determined in a reproducible manner. Although they correlate well with the presence of atherosclerosis and predict future coronary risk. there is little role for monitoring progression of coronary artery calcification in order to assess the response to lipid lowering therapy. Computed tomography can be used reliably to predict graft patency in patients who have undergone coronary artery bypass grafting, and is an acceptable non-invasive alternative to invasive coronary angiography. Magnetic resonance imaging techniques ' can be employed in a feasible, timely and reproducible manner to detect plaque characteristics associated with acute atherothrombotic disease
AFFIRM: Affinity Fusion-based Framework for Iteratively Random Motion correction of multi-slice fetal brain MRI
Multi-slice magnetic resonance images of the fetal brain are usually
contaminated by severe and arbitrary fetal and maternal motion. Hence, stable
and robust motion correction is necessary to reconstruct high-resolution 3D
fetal brain volume for clinical diagnosis and quantitative analysis. However,
the conventional registration-based correction has a limited capture range and
is insufficient for detecting relatively large motions. Here, we present a
novel Affinity Fusion-based Framework for Iteratively Random Motion (AFFIRM)
correction of the multi-slice fetal brain MRI. It learns the sequential motion
from multiple stacks of slices and integrates the features between 2D slices
and reconstructed 3D volume using affinity fusion, which resembles the
iterations between slice-to-volume registration and volumetric reconstruction
in the regular pipeline. The method accurately estimates the motion regardless
of brain orientations and outperforms other state-of-the-art learning-based
methods on the simulated motion-corrupted data, with a 48.4% reduction of mean
absolute error for rotation and 61.3% for displacement. We then incorporated
AFFIRM into the multi-resolution slice-to-volume registration and tested it on
the real-world fetal MRI scans at different gestation stages. The results
indicated that adding AFFIRM to the conventional pipeline improved the success
rate of fetal brain super-resolution reconstruction from 77.2% to 91.9%
Active swarms on a sphere
Here we show that coupling to curvature has profound effects on collective
motion in active systems, leading to patterns not observed in flat space.
Biological examples of such active motion in curved environments are numerous:
curvature and tissue folding are crucial during gastrulation, epithelial and
endothelial cells move on constantly growing, curved crypts and vili in the
gut, and the mammalian corneal epithelium grows in a steady-state vortex
pattern. On the physics side, droplets coated with actively driven microtubule
bundles show active nematic patterns. We study a model of self-propelled
particles with polar alignment on a sphere. Hallmarks of these motion patterns
are a polar vortex and a circulating band arising due to the incompatibility
between spherical topology and uniform motion - a consequence of the hairy ball
theorem. We present analytical results showing that frustration due to
curvature leads to stable elastic distortions storing energy in the band.Comment: 5 pages, 4 figures plus Supporting Informatio
Bulk Fields and Supersymmetry in a Slice of AdS
Five-dimensional models where the bulk is a slice of AdS have the virtue of
solving the hierarchy problem. The electroweak scale is generated by a ``warp''
factor of the induced metric on the brane where the standard model fields live.
However, it is not necessary to confine the standard model fields on the brane
and we analyze the possibility of having the fields actually living in the
slice of AdS. Specifically, we study the behaviour of fermions, gauge bosons
and scalars in this geometry and their implications on electroweak physics.
These scenarios can provide an explanation of the fermion mass hierarchy by
warp factors. We also consider the case of supersymmetry in the bulk, and
analyze the conditions on the mass spectrum. Finally, a model is proposed where
the warp factor generates a small (TeV) supersymmetry-breaking scale, with the
gauge interactions mediating the breaking to the scalar sector.Comment: 22 pages, 2 figures, LaTe
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