2 research outputs found
Incorporating white matter microstructure in the estimation of magnetic susceptibility in ex-vivo mouse brain
Accurate estimation of microscopic magnetic field variations induced in
biological tissue can be valuable for mapping tissue composition in health and
disease. Here, we present an extension to Quantitative susceptibility mapping
(QSM) to account for local white matter (WM) microstructure by using our
previously presented model for solid cylinders with arbitrary orientations to
describe axons in terms of concentric cylinders. We show how multi-gradient
echo (MGE) and diffusion MRI (dMRI) images can be combined to estimate an
apparent scalar susceptibility. Experiments in mouse brains acquired at
ultrahigh field shows the mesoscopic contribution due to WM microstructure to
be substantial, with a magnitude up to 70% of the total frequency shift in
highly anisotropic WM. This in turn changed estimated susceptibility values up
to 56% in WM compared to standard QSM. Our work underscores how microstructural
field effects impact susceptibility estimates, and should not be neglected when
imaging anisotropic tissue such as brain WM.Comment: 33 pages, 7 figure