Qualitative analysis of solutions to mixed-order positive linear coupled systems with bounded or unbounded delays

This paper addresses the qualitative theory of mixed-order positive linear coupled systems with bounded or unbounded delays. First, we introduce a general result on the existence and uniqueness of solutions to mixed-order linear coupled systems with time-varying delays. Next, we obtain the necessary and sufficient criteria which characterize the positivity of a mixed-order delay linear coupled system. Our main contribution is in Section 5. More precisely, by using a smoothness property of solutions to fractional differential equations and developing a new appropriated comparison principle for solutions to mixed-order delayed positive systems, we prove the attractivity of mixed-order non-homogeneous linear positive coupled systems with bounded or unbounded delays. We also establish a necessary and sufficient condition to characterize the stability of homogeneous systems. As a consequence of these results, we show the smallest asymptotic bound of solutions to mixed-order delay non-homogeneous linear positive coupled systems where disturbances are continuous and bounded. Finally, we provide numerical simulations to illustrate the proposed theoretical results

Positivity of Continuous-Time Descriptor Systems With Time Delays

This technical note is concerned with positivity characteristic of continuous-time descriptor systems with time delays. First, a set of necessary and sufficient conditions is presented to check the property. Then, considering a descriptor time-delay system with two assumptions, a new time-delay system is established whose positivity is equivalent to that of the original system. Furthermore, a set of necessary and sufficient conditions is provided to check the positivity of the new system. Finally, a numerical example is given to illustrate the validity of the results obtained

Time-delayed models of gene regulatory networks

We discuss different mathematical models of gene regulatory networks as relevant to the onset and development of cancer. After discussion of alternativemodelling approaches, we use a paradigmatic two-gene network to focus on the role played by time delays in the dynamics of gene regulatory networks. We contrast the dynamics of the reduced model arising in the limit of fast mRNA dynamics with that of the full model. The review concludes with the discussion of some open problems