Extracting fetal heart beats from maternal abdominal recordings: Selection of the optimal principal components

This study presents a systematic comparison of different approaches to the automated selection of the principal components (PC) which optimise the detection of maternal and fetal heart beats from non-invasive maternal abdominal recordings. A public database of 75 4-channel non-invasive maternal abdominal recordings was used for training the algorithm. Four methods were developed and assessed to determine the optimal PC: (1) power spectral distribution, (2) root mean square, (3) sample entropy, and (4) QRS template. The sensitivity of the performance of the algorithm to large-amplitude noise removal (by wavelet de-noising) and maternal beat cancellation methods were also assessed. The accuracy of maternal and fetal beat detection was assessed against reference annotations and quantified using the detection accuracy score F1 [2*PPV*Se / (PPV + Se)], sensitivity (Se), and positive predictive value (PPV). The best performing implementation was assessed on a test dataset of 100 recordings and the agreement between the computed and the reference fetal heart rate (fHR) and fetal RR (fRR) time series quantified. The best performance for detecting maternal beats (F1 99.3%, Se 99.0%, PPV 99.7%) was obtained when using the QRS template method to select the optimal maternal PC and applying wavelet de-noising. The best performance for detecting fetal beats (F1 89.8%, Se 89.3%, PPV 90.5%) was obtained when the optimal fetal PC was selected using the sample entropy method and utilising a fixed-length time window for the cancellation of the maternal beats. The performance on the test dataset was 142.7 beats2/min2 for fHR and 19.9 ms for fRR, ranking respectively 14 and 17 (out of 29) when compared to the other algorithms presented at the Physionet Challenge 2013

An Accurate EEGNet-based Motor-Imagery Brain-Computer Interface for Low-Power Edge Computing

This paper presents an accurate and robust embedded motor-imagery brain-computer interface (MI-BCI). The proposed novel model, based on EEGNet, matches the requirements of memory footprint and computational resources of low-power microcontroller units (MCUs), such as the ARM Cortex-M family. Furthermore, the paper presents a set of methods, including temporal downsampling, channel selection, and narrowing of the classification window, to further scale down the model to relax memory requirements with negligible accuracy degradation. Experimental results on the Physionet EEG Motor Movement/Imagery Dataset show that standard EEGNet achieves 82.43%, 75.07%, and 65.07% classification accuracy on 2-, 3-, and 4-class MI tasks in global validation, outperforming the state-of-the-art (SoA) convolutional neural network (CNN) by 2.05%, 5.25%, and 5.48%. Our novel method further scales down the standard EEGNet at a negligible accuracy loss of 0.31% with 7.6x memory footprint reduction and a small accuracy loss of 2.51% with 15x reduction. The scaled models are deployed on a commercial Cortex-M4F MCU taking 101ms and consuming 4.28mJ per inference for operating the smallest model, and on a Cortex-M7 with 44ms and 18.1mJ per inference for the medium-sized model, enabling a fully autonomous, wearable, and accurate low-power BCI

Protected Health Information filter (Philter): accurately and securely de-identifying free-text clinical notes.

There is a great and growing need to ascertain what exactly is the state of a patient, in terms of disease progression, actual care practices, pathology, adverse events, and much more, beyond the paucity of data available in structured medical record data. Ascertaining these harder-to-reach data elements is now critical for the accurate phenotyping of complex traits, detection of adverse outcomes, efficacy of off-label drug use, and longitudinal patient surveillance. Clinical notes often contain the most detailed and relevant digital information about individual patients, the nuances of their diseases, the treatment strategies selected by physicians, and the resulting outcomes. However, notes remain largely unused for research because they contain Protected Health Information (PHI), which is synonymous with individually identifying data. Previous clinical note de-identification approaches have been rigid and still too inaccurate to see any substantial real-world use, primarily because they have been trained with too small medical text corpora. To build a new de-identification tool, we created the largest manually annotated clinical note corpus for PHI and develop a customizable open-source de-identification software called Philter ("Protected Health Information filter"). Here we describe the design and evaluation of Philter, and show how it offers substantial real-world improvements over prior methods