About differential inequalities for nonlocal boundary value problems with impulsive delay equations

summary:We propose results about sign-constancy of Green's functions to impulsive nonlocal boundary value problems in a form of theorems about differential inequalities. One of the ideas of our approach is to construct Green's functions of boundary value problems for simple auxiliary differential equations with impulses. Careful analysis of these Green's functions allows us to get conclusions about the sign-constancy of Green's functions to given functional differential boundary value problems, using the technique of theorems about differential and integral inequalities and estimates of spectral radii of the corresponding compact operators in the space of essential bounded functions

Impulsive perturbations to differential equations: stable/unstable pseudo-manifolds, heteroclinic connections, and flux

State-dependent time-impulsive perturbations to a two-dimensional autonomous flow with stable and unstable manifolds are analysed by posing in terms of an integral equation which is valid in both forwards- and backwards-time. The impulses destroy the smooth invariant manifolds, necessitating new definitions for stable and unstable pseudo-manifolds. Their time-evolution is characterised by solving a Volterra integral equation of the second kind with discontinuous inhomogeniety. A criteria for heteroclinic trajectory persistence in this impulsive context is developed, as is a quantification of an instantaneous flux across broken heteroclinic manifolds. Several examples, including a kicked Duffing oscillator and an underwater explosion in the vicinity of an eddy, are used to illustrate the theory

Existence and Asymptotic Stability of Periodic Solutions for Impulsive Delay Evolution Equations

In this paper, we are devoted to consider the periodic problem for the impulsive evolution equations with delay in Banach space. By using operator semigroups theory and fixed point theorem, we establish some new existence theorems of periodic mild solutions for the equations. In addition, with the aid of an integral inequality with impulsive and delay, we present essential conditions on the nonlinear and impulse functions to guarantee that the equations have an asymptotically stable $\omega$-periodic mild solution

From regional pulse vaccination to global disease eradication: insights from a mathematical model of Poliomyelitis

Mass-vaccination campaigns are an important strategy in the global fight against poliomyelitis and measles. The large-scale logistics required for these mass immunisation campaigns magnifies the need for research into the effectiveness and optimal deployment of pulse vaccination. In order to better understand this control strategy, we propose a mathematical model accounting for the disease dynamics in connected regions, incorporating seasonality, environmental reservoirs and independent periodic pulse vaccination schedules in each region. The effective reproduction number, $R_e$, is defined and proved to be a global threshold for persistence of the disease. Analytical and numerical calculations show the importance of synchronising the pulse vaccinations in connected regions and the timing of the pulses with respect to the pathogen circulation seasonality. Our results indicate that it may be crucial for mass-vaccination programs, such as national immunisation days, to be synchronised across different regions. In addition, simulations show that a migration imbalance can increase $R_e$ and alter how pulse vaccination should be optimally distributed among the patches, similar to results found with constant-rate vaccination. Furthermore, contrary to the case of constant-rate vaccination, the fraction of environmental transmission affects the value of $R_e$ when pulse vaccination is present.Comment: Added section 6.1, made other revisions, changed titl