MedGAN: Medical Image Translation using GANs

Image-to-image translation is considered a new frontier in the field of medical image analysis, with numerous potential applications. However, a large portion of recent approaches offers individualized solutions based on specialized task-specific architectures or require refinement through non-end-to-end training. In this paper, we propose a new framework, named MedGAN, for medical image-to-image translation which operates on the image level in an end-to-end manner. MedGAN builds upon recent advances in the field of generative adversarial networks (GANs) by merging the adversarial framework with a new combination of non-adversarial losses. We utilize a discriminator network as a trainable feature extractor which penalizes the discrepancy between the translated medical images and the desired modalities. Moreover, style-transfer losses are utilized to match the textures and fine-structures of the desired target images to the translated images. Additionally, we present a new generator architecture, titled CasNet, which enhances the sharpness of the translated medical outputs through progressive refinement via encoder-decoder pairs. Without any application-specific modifications, we apply MedGAN on three different tasks: PET-CT translation, correction of MR motion artefacts and PET image denoising. Perceptual analysis by radiologists and quantitative evaluations illustrate that the MedGAN outperforms other existing translation approaches.Comment: 16 pages, 8 figure

Self-imitating Feedback Generation Using GAN for Computer-Assisted Pronunciation Training

Self-imitating feedback is an effective and learner-friendly method for non-native learners in Computer-Assisted Pronunciation Training. Acoustic characteristics in native utterances are extracted and transplanted onto learner's own speech input, and given back to the learner as a corrective feedback. Previous works focused on speech conversion using prosodic transplantation techniques based on PSOLA algorithm. Motivated by the visual differences found in spectrograms of native and non-native speeches, we investigated applying GAN to generate self-imitating feedback by utilizing generator's ability through adversarial training. Because this mapping is highly under-constrained, we also adopt cycle consistency loss to encourage the output to preserve the global structure, which is shared by native and non-native utterances. Trained on 97,200 spectrogram images of short utterances produced by native and non-native speakers of Korean, the generator is able to successfully transform the non-native spectrogram input to a spectrogram with properties of self-imitating feedback. Furthermore, the transformed spectrogram shows segmental corrections that cannot be obtained by prosodic transplantation. Perceptual test comparing the self-imitating and correcting abilities of our method with the baseline PSOLA method shows that the generative approach with cycle consistency loss is promising

Adaptive transfer functions: improved multiresolution visualization of medical models

The final publication is available at Springer via http://dx.doi.org/10.1007/s00371-016-1253-9Medical datasets are continuously increasing in size. Although larger models may be available for certain research purposes, in the common clinical practice the models are usually of up to 512x512x2000 voxels. These resolutions exceed the capabilities of conventional GPUs, the ones usually found in the medical doctors’ desktop PCs. Commercial solutions typically reduce the data by downsampling the dataset iteratively until it fits the available target specifications. The data loss reduces the visualization quality and this is not commonly compensated with other actions that might alleviate its effects. In this paper, we propose adaptive transfer functions, an algorithm that improves the transfer function in downsampled multiresolution models so that the quality of renderings is highly improved. The technique is simple and lightweight, and it is suitable, not only to visualize huge models that would not fit in a GPU, but also to render not-so-large models in mobile GPUs, which are less capable than their desktop counterparts. Moreover, it can also be used to accelerate rendering frame rates using lower levels of the multiresolution hierarchy while still maintaining high-quality results in a focus and context approach. We also show an evaluation of these results based on perceptual metrics.Peer ReviewedPostprint (author's final draft