Mining protein function from text using term-based support vector machines

<p>Abstract</p> <p>Background</p> <p>Text mining has spurred huge interest in the domain of biology. The goal of the BioCreAtIvE exercise was to evaluate the performance of current text mining systems. We participated in Task 2, which addressed assigning Gene Ontology terms to human proteins and selecting relevant evidence from full-text documents. We approached it as a modified form of the document classification task. We used a supervised machine-learning approach (based on support vector machines) to assign protein function and select passages that support the assignments. As classification features, we used a protein's co-occurring terms that were automatically extracted from documents.</p> <p>Results</p> <p>The results evaluated by curators were modest, and quite variable for different problems: in many cases we have relatively good assignment of GO terms to proteins, but the selected supporting text was typically non-relevant (precision spanning from 3% to 50%). The method appears to work best when a substantial set of relevant documents is obtained, while it works poorly on single documents and/or short passages. The initial results suggest that our approach can also mine annotations from text even when an explicit statement relating a protein to a GO term is absent.</p> <p>Conclusion</p> <p>A machine learning approach to mining protein function predictions from text can yield good performance only if sufficient training data is available, and significant amount of supporting data is used for prediction. The most promising results are for combined document retrieval and GO term assignment, which calls for the integration of methods developed in BioCreAtIvE Task 1 and Task 2.</p

Search beyond traditional probabilistic information retrieval

"This thesis focuses on search beyond probabilistic information retrieval. Three ap- proached are proposed beyond the traditional probabilistic modelling. First, term associ- ation is deeply examined. Term association considers the term dependency using a factor analysis based model, instead of treating each term independently. Latent factors, con- sidered the same as the hidden variables of ""eliteness"" introduced by Robertson et al. to gain understanding of the relation among term occurrences and relevance, are measured by the dependencies and occurrences of term sequences and subsequences. Second, an entity-based ranking approach is proposed in an entity system named ""EntityCube"" which has been released by Microsoft for public use. A summarization page is given to summarize the entity information over multiple documents such that the truly relevant entities can be highly possibly searched from multiple documents through integrating the local relevance contributed by proximity and the global enhancer by topic model. Third, multi-source fusion sets up a meta-search engine to combine the ""knowledge"" from different sources. Meta-features, distilled as high-level categories, are deployed to diversify the baselines. Three modified fusion methods are employed, which are re- ciprocal, CombMNZ and CombSUM with three expanded versions. Through extensive experiments on the standard large-scale TREC Genomics data sets, the TREC HARD data sets and the Microsoft EntityCube Web collections, the proposed extended models beyond probabilistic information retrieval show their effectiveness and superiority.

Semantic concept extraction from electronic medical records for enhancing information retrieval performance

With the healthcare industry increasingly using EMRs, there emerges an opportunity for knowledge discovery within the healthcare domain that was not possible with paper-based medical records. One such opportunity is to discover UMLS concepts from EMRs. However, with opportunities come challenges that need to be addressed. Medical verbiage is very different from common English verbiage and it is reasonable to assume extracting any information from medical text requires different protocols than what is currently used in common English text. This thesis proposes two new semantic matching models: Term-Based Matching and CUI-Based Matching. These two models use specialized biomedical text mining tools that extract medical concepts from EMRs. Extensive experiments to rank the extracted concepts are conducted on the University of Pittsburgh BLULab NLP Repository for the TREC 2011 Medical Records track dataset that consists of 101,711 EMRs that contain concepts in 34 predefined topics. This thesis compares the proposed semantic matching models against the traditional weighting equations and information retrieval tools used in the academic world today

Using Learning to Rank Approach to Promoting Diversity for Biomedical Information Retrieval with Wikipedia

In most of the traditional information retrieval (IR) models, the independent relevance assumption is taken, which assumes the relevance of a document is independent of other documents. However, the pitfall of this is the high redundancy and low diversity of retrieval result. This has been seen in many scenarios, especially in biomedical IR, where the information need of one query may refer to different aspects. Promoting diversity in IR takes the relationship between documents into account. Unlike previous studies, we tackle this problem in the learning to rank perspective. The main challenges are how to find salient features for biomedical data and how to integrate dynamic features into the ranking model. To address these challenges, Wikipedia is used to detect topics of documents for generating diversity biased features. A combined model is proposed and studied to learn a diversified ranking result. Experiment results show the proposed method outperforms baseline models