The Parallelism Motifs of Genomic Data Analysis

Genomic data sets are growing dramatically as the cost of sequencing continues to decline and small sequencing devices become available. Enormous community databases store and share this data with the research community, but some of these genomic data analysis problems require large scale computational platforms to meet both the memory and computational requirements. These applications differ from scientific simulations that dominate the workload on high end parallel systems today and place different requirements on programming support, software libraries, and parallel architectural design. For example, they involve irregular communication patterns such as asynchronous updates to shared data structures. We consider several problems in high performance genomics analysis, including alignment, profiling, clustering, and assembly for both single genomes and metagenomes. We identify some of the common computational patterns or motifs that help inform parallelization strategies and compare our motifs to some of the established lists, arguing that at least two key patterns, sorting and hashing, are missing

Link prediction in very large directed graphs: Exploiting hierarchical properties in parallel

Link prediction is a link mining task that tries to find new edges within a given graph. Among the targets of link prediction there is large directed graphs, which are frequent structures nowadays. The typical sparsity of large graphs demands of high precision predictions in order to obtain usable results. However, the size of those graphs only permits the execution of scalable algorithms. As a trade-off between those two problems we recently proposed a link prediction algorithm for directed graphs that exploits hierarchical properties. The algorithm can be classified as a local score, which entails scalability. Unlike the rest of local scores, our proposal assumes the existence of an underlying model for the data which allows it to produce predictions with a higher precision. We test the validity of its hierarchical assumptions on two clearly hierarchical data sets, one of them based on RDF. Then we test it on a non-hierarchical data set based on Wikipedia to demonstrate its broad applicability. Given the computational complexity of link prediction in very large graphs we also introduce some general recommendations useful to make of link prediction an efficiently parallelized problem.Peer ReviewedPostprint (published version