23,206 research outputs found
Developing and applying heterogeneous phylogenetic models with XRate
Modeling sequence evolution on phylogenetic trees is a useful technique in
computational biology. Especially powerful are models which take account of the
heterogeneous nature of sequence evolution according to the "grammar" of the
encoded gene features. However, beyond a modest level of model complexity,
manual coding of models becomes prohibitively labor-intensive. We demonstrate,
via a set of case studies, the new built-in model-prototyping capabilities of
XRate (macros and Scheme extensions). These features allow rapid implementation
of phylogenetic models which would have previously been far more
labor-intensive. XRate's new capabilities for lineage-specific models,
ancestral sequence reconstruction, and improved annotation output are also
discussed. XRate's flexible model-specification capabilities and computational
efficiency make it well-suited to developing and prototyping phylogenetic
grammar models. XRate is available as part of the DART software package:
http://biowiki.org/DART .Comment: 34 pages, 3 figures, glossary of XRate model terminolog
Learning Latent Tree Graphical Models
We study the problem of learning a latent tree graphical model where samples
are available only from a subset of variables. We propose two consistent and
computationally efficient algorithms for learning minimal latent trees, that
is, trees without any redundant hidden nodes. Unlike many existing methods, the
observed nodes (or variables) are not constrained to be leaf nodes. Our first
algorithm, recursive grouping, builds the latent tree recursively by
identifying sibling groups using so-called information distances. One of the
main contributions of this work is our second algorithm, which we refer to as
CLGrouping. CLGrouping starts with a pre-processing procedure in which a tree
over the observed variables is constructed. This global step groups the
observed nodes that are likely to be close to each other in the true latent
tree, thereby guiding subsequent recursive grouping (or equivalent procedures)
on much smaller subsets of variables. This results in more accurate and
efficient learning of latent trees. We also present regularized versions of our
algorithms that learn latent tree approximations of arbitrary distributions. We
compare the proposed algorithms to other methods by performing extensive
numerical experiments on various latent tree graphical models such as hidden
Markov models and star graphs. In addition, we demonstrate the applicability of
our methods on real-world datasets by modeling the dependency structure of
monthly stock returns in the S&P index and of the words in the 20 newsgroups
dataset
The Mathematics of Phylogenomics
The grand challenges in biology today are being shaped by powerful
high-throughput technologies that have revealed the genomes of many organisms,
global expression patterns of genes and detailed information about variation
within populations. We are therefore able to ask, for the first time,
fundamental questions about the evolution of genomes, the structure of genes
and their regulation, and the connections between genotypes and phenotypes of
individuals. The answers to these questions are all predicated on progress in a
variety of computational, statistical, and mathematical fields.
The rapid growth in the characterization of genomes has led to the
advancement of a new discipline called Phylogenomics. This discipline results
from the combination of two major fields in the life sciences: Genomics, i.e.,
the study of the function and structure of genes and genomes; and Molecular
Phylogenetics, i.e., the study of the hierarchical evolutionary relationships
among organisms and their genomes. The objective of this article is to offer
mathematicians a first introduction to this emerging field, and to discuss
specific mathematical problems and developments arising from phylogenomics.Comment: 41 pages, 4 figure
Deep Tree Transductions - A Short Survey
The paper surveys recent extensions of the Long-Short Term Memory networks to
handle tree structures from the perspective of learning non-trivial forms of
isomorph structured transductions. It provides a discussion of modern TreeLSTM
models, showing the effect of the bias induced by the direction of tree
processing. An empirical analysis is performed on real-world benchmarks,
highlighting how there is no single model adequate to effectively approach all
transduction problems.Comment: To appear in the Proceedings of the 2019 INNS Big Data and Deep
Learning (INNSBDDL 2019). arXiv admin note: text overlap with
arXiv:1809.0909
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