XXV Congreso Argentino de Ciencias de la Computación - CACIC 2019: libro de actas

Trabajos presentados en el XXV Congreso Argentino de Ciencias de la Computación (CACIC), celebrado en la ciudad de Río Cuarto los días 14 al 18 de octubre de 2019 organizado por la Red de Universidades con Carreras en Informática (RedUNCI) y Facultad de Ciencias Exactas, Físico-Químicas y Naturales - Universidad Nacional de Río CuartoRed de Universidades con Carreras en Informátic

XXV Congreso Argentino de Ciencias de la Computación - CACIC 2019: libro de actas

Trabajos presentados en el XXV Congreso Argentino de Ciencias de la Computación (CACIC), celebrado en la ciudad de Río Cuarto los días 14 al 18 de octubre de 2019 organizado por la Red de Universidades con Carreras en Informática (RedUNCI) y Facultad de Ciencias Exactas, Físico-Químicas y Naturales - Universidad Nacional de Río CuartoRed de Universidades con Carreras en Informátic

The effects of innovation on channels on distribution

There exists a certain wisdom in management which accepts that there will always be problems which by their very nature are insoluble; nevertheless many remain which, due to the application of particular management skills, are potentially more capable of solution. This research programme is pitched at the latter category in the belief that at least some improvement in current practice is feasible provided a more fundamental level of understanding of the relevant (underlying) mechanisms can be achieved. Professor E.C. Zeeman of Warwick University confirms this view with the comment, made to the writer in conversation, that "explanation should reduce the arbitrariness of description". It is only through attainment of this 'explanation' level of understanding that meaningful strategic action becomes possible. Primarily our aim here is to explain and, if possible, predict how channels of· distribution react when subjected to the forces of· change, and more specifically, change in the form of innovation A review of the literature pertinent to innovation reveals some disturbing knowledge gaps. In particular, there appears to be a general ignorance of the possible consequences of innovation, and a corresponding lack of any concerted attempt to suggest how innovation (and its consequences) may be managed in an interorganizational context. Similarly, a state-of-the-art review of the distribution channels literature leads us to conclude that, like so much of the_ general marketing literature, it is predominantly descriptive in nature. Many of the issues are developed in piecemeal fashion and hence there is no generally applicable conceptualization. Given these problems,· any attempt at predicting the effects of innovation on channel behaviour patterns is premature and bound to fail. In order to even approach our original objective therefore, it firstly becomes necessary to attempt development of a new conceptual scaffolding with 'explanation' and 'predictive' capabilities. to do this we chose to search well outside the accepted boundaries of management science literature, seeking concepts from a wide range of disciplines and inter-disciplines, building the bridges between these and observed behaviour, and using systems theory as the core around which to develop a model with more general applicability. Our research orientation is therefore predominantly theoretical but, nevertheless has substantial practical relevance. Two actual cases of significant recent innovations in the UK food/ grocery industry are used as vehicles to partially test the model, and the analysis is extended into the predictive dimension using changes delineated by a Delphi futures forecast. The intention is to use the model to anticipate (or predict) what systemic effects can be expected subsequent to the introduction of innovation. The emphasis throughout is on assessing the implications of such changes using the language and concepts -central to our model. Because the external environment is such a key influential in any 'open system' situation, considerable attention is paid to developing this aspect. Since. we are concerned with finding a new way of viewing distribution channel systems, we have adopted a macro orientation throughout" in the belief that detailed refinements can be undertaken by future researchers working within the framework established here. As such soundness of the overall logic scheme is regarded as critical, and certainly of more fundamental importance than any requirement to measure .,, individual parameters. The value of such a broad orientation should overshadow any imperfections in detail which will almost certainly emerge. Generally, the model (and its component parameters) look promising, and our findings tend to indicate that it is no longer necessary to dilute the true complexity of distribution channel systems in order to achieve some understanding of what is happening within. It is now possible to evaluate in a conceptual sense, the effects of innovation on a channel system using stability criteria, and further, to assess the viability of such innovation in terms of Ashby's 'variety' principle.Ph

Dichotomic role of NAADP/two-pore channel 2/Ca2+ signaling in regulating neural differentiation of mouse embryonic stem cells

Poster Presentation - Stem Cells and Pluripotency: abstract no. 1866The mobilization of intracellular Ca2+stores is involved in diverse cellular functions, including cell proliferation and differentiation. At least three endogenous Ca2+mobilizing messengers have been identified, including inositol trisphosphate (IP3), cyclic adenosine diphosphoribose (cADPR), and nicotinic adenine acid dinucleotide phosphate (NAADP). Similar to IP3, NAADP can mobilize calcium release in a wide variety of cell types and species, from plants to animals. Moreover, it has been previously shown that NAADP but not IP3-mediated Ca2+increases can potently induce neuronal differentiation in PC12 cells. Recently, two pore channels (TPCs) have been identified as a novel family of NAADP-gated calcium release channels in endolysosome. Therefore, it is of great interest to examine the role of TPC2 in the neural differentiation of mouse ES cells. We found that the expression of TPC2 is markedly decreased during the initial ES cell entry into neural progenitors, and the levels of TPC2 gradually rebound during the late stages of neurogenesis. Correspondingly, perturbing the NAADP signaling by TPC2 knockdown accelerates mouse ES cell differentiation into neural progenitors but inhibits these neural progenitors from committing to the final neural lineage. Interestingly, TPC2 knockdown has no effect on the differentiation of astrocytes and oligodendrocytes of mouse ES cells. Overexpression of TPC2, on the other hand, inhibits mouse ES cell from entering the neural lineage. Taken together, our data indicate that the NAADP/TPC2-mediated Ca2+signaling pathway plays a temporal and dichotomic role in modulating the neural lineage entry of ES cells; in that NAADP signaling antagonizes ES cell entry to early neural progenitors, but promotes late neural differentiation.postprin