Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs

Connes-Lott model building on the two-sphere

In this work we examine generalized Connes-Lott models on the two-sphere. The Hilbert space of the continuum spectral triple is taken as the space of sections of a twisted spinor bundle, allowing for nontrivial topological structure (magnetic monopoles). The finitely generated projective module over the full algebra is also taken as topologically non-trivial, which is possible over $S^2$. We also construct a real spectral triple enlarging this Hilbert space to include "particle" and "anti-particle" fields.Comment: 57 pages, LATE

Convergence of the Allen-Cahn equation with Neumann boundary conditions

We study a singular limit problem of the Allen-Cahn equation with Neumann boundary conditions and general initial data of uniformly bounded energy. We prove that the time-parametrized family of limit energy measures is Brakke's mean curvature flow with a generalized right angle condition on the boundary.Comment: 26 pages, 1 figur

Developing real-life driving simulations for novice driver education

This paper will describe the technological aspects of producing live-action videos of real traffic scenarios for a new driver education training CD-ROM (CD DRIVES) aimed at novice drivers in New Zealand. CD-DRIVES was created in order to help young drivers practise crucial higher level driving skills such as eye scanning, hazard detection and risk management. We will present a roadmap of the technological advances made through hardware, software and processes used in the production and post-production stages of CD-DRIVES

On the reactions p + p -> p + Lambda + K^+ and p + p -> p + Sigma^0 + K^+ near thresholds

The cross sections for the reactions of the strange production p + p -> p + Lambda + K^+ and p + p -> p + Sigma^0 + K^+ near thresholds of the final states p Lambda K^+ and p Sigma^0 K^+ are calculated in the effective Lagrangian approach. Our approach is based on the dominant contribution of the one-pion exchange and strong interaction of the colliding protons in the initial state. The theoretical values of the cross sections agree reasonably well with the experimental data. The polarization properties of the Lambda and Sigma^0 hyperons are discussed.Comment: 15 pages, 1 Postscript figure, Latex, to appear in Eur. Phys. J

Lyman Alpha Emitter Evolution in the Reionization Epoch

Combining cosmological SPH simulations with a previously developed Lyman Alpha production/transmission model and the Early Reionization Model (ERM, reionization ends at redshift z~7), we obtain Lyman Alpha and UV Luminosity Functions (LFs) for Lyman Alpha Emitters (LAEs) for redshifts between 5.7 and 7.6. Matching model results to observations at z~5.7 requires escape fractions of Lyman Alpha, f_alpha=0.3, and UV (non-ionizing) continuum photons, f_c=0.22, corresponding to a color excess, E(B-V)=0.15. We find that (i) f_c increases towards higher redshifts, due the decreasing mean dust content of galaxies, (ii) the evolution of f_alpha/f_c hints at the dust content of the ISM becoming progressively inhomogeneous/clumped with decreasing redshift. The clustering photoionization boost is important during the initial reionization phases but has little effect on the Lyman Alpha LF for a highly ionized IGM. Halo (stellar) masses are in the range 10.0 < \log M_h < 11.8 (8.1 < \log M_* < 10.4) with M_h \propto M_*^{0.64}. The star formation rates are between 3-120 solar masses per year, mass-weighted mean ages are greater than 20 Myr at all redshifts, while the mean stellar metallicity increases from Z=0.12 to 0.22 solar metallicity from z~7.6 to z~5.7; both age and metallicity positively correlate with stellar mass. The brightest LAEs are all characterized by large star formation rates and intermediate ages (~200 Myr), while objects in the faint end of the Lyman Alpha LF show large age and star formation rate spreads. With no more free parameters, the Spectral Energy Distributions of three LAE at z~5.7 observed by Lai et al. (2007) are well reproduced by an intermediate age (182-220 Myr) stellar population and the above E(B-V) value.Comment: 13 pages, 9 figures, accepted to MNRA

Empirical Determination of Threshold Partial Wave Amplitudes in pp→ppωp p \to p p \omega

Using the model independent irreducible tensor approach to $\omega$ production in $pp$ collisions, we show theoretically that, it is advantageous to measure experimentally the polarization of $\omega$, in addition to the proposed experimental study employing a polarized beam and a polarized target.Comment: 6 pages, 1 Table, Latex-2

Relativistic kinetic theory of magnetoplasmas

Recently, an increasing interest in astrophysical as well as laboratory plasmas has been manifested in reference to the existence of relativistic flows, related in turn to the production of intense electric fields in magnetized systems. Such phenomena require their description in the framework of a consistent relativistic kinetic theory, rather than on relativistic MHD equations, subject to specific closure conditions. The purpose of this work is to apply the relativistic single-particle guiding-center theory developed by Beklemishev and Tessarotto, including the nonlinear treatment of small-wavelength EM perturbations which may naturally arise in such systems. As a result, a closed set of relativistic gyrokinetic equations, consisting of the collisionless relativistic kinetic equation, expressed in hybrid gyrokinetic variables, and the averaged Maxwell's equations, is derived for an arbitrary four-dimensional coordinate system.Comment: 6 pages, 1 figure. Contributed to the Proceedings of the 24th International Symposium on Rarefied Gas Dynamics, July 10-16, 2004 Porto Giardino Monopoli (Bari), Ital

¹⁴C AMS at SUERC: improving QA data from the 5 MV tandem AMS and 250 kV SSAMS

In 2003, a National Electrostatics Corporation (NEC) 5MV tandem accelerator mass spectrometer was installed at SUERC, providing the radiocarbon laboratory with 14C measurements to 4–5‰ repeatability. In 2007, a 250kV single-stage accelerator mass spectrometer (SSAMS) was added to provide additional 14C capability and is now the preferred system for 14C analysis. Changes to the technology and to our operations are evident in our copious quality assurance data: typically, we now use the 134-position MC-SNICS source, which is filled to capacity. Measurement of standards shows that spectrometer running without the complication of on-line δ13C evaluation is a good operational compromise. Currently, 3‰ 14C/13C measurements are routinely achieved for samples up to nearly 3 half-lives old by consistent sample preparation and an automated data acquisition algorithm with sample random access for measurement repeats. Background and known-age standard data are presented for the period 2003–2008 for the 5MV system and 2007–2008 for the SSAMS, to demonstrate the improvements in data quality