2,007,604 research outputs found
Outros
XXXII Congresso Brasileiro de Zoologia, Foz do Iguaçu, 2018. Tema: Desafios e perspectivas para a Zoologia na América LatinaCaderno de Resumos de Trabalhos da Área temática Outros, do XXXII Congresso Brasileiro de ZoologiaSociedade Brasileira de Zoologia (SBZ) e Universidade Federal da Integração Latino-Americana (Unila
Conhecimento profissional do jovem professor de Matemática sobre os alunos
Neste artigo aborda-se o conhecimento profissional de professores de Matemática e de professores do 1.º ciclo do ensino básico em início de carreira, sobre os alunos. A importância deste tipo de conhecimento do professor deriva da sua estreita relação com as práticas de sala de aula, qualquer que seja a perspectiva teórica que se adopte sobre esta relação. Neste estudo, assume-se uma relação dialéctica entre ambos não fazendo sentido falar de um sem o outro. Assim, por um lado, o conhecimento profissional tem uma fonte tanto disciplinar como experiencial, resultando da reflexão e investigação dos professores sobre as práticas; por outro, o conhecimento é extremamente importante como inspirador das práticas, apontando ao professor possíveis rumos de acção
Effectiveness of delayed-release dimethyl fumarate on patient-reported outcomes and clinical measures in patients with relapsing-remitting multiple sclerosis in a real-world clinical setting: PROTEC.
Ensaio clínico PROTEC, Protocolo nº 109MS408Abstract
BACKGROUND:
Patient-reported outcomes (PRO) and clinical outcomes give a broad assessment of relapsing-remitting multiple sclerosis (RRMS) disease.
OBJECTIVE:
The aim is to evaluate the effectiveness of delayed-release dimethyl fumarate (DMF) on disease activity and PROs in patients with RRMS in the clinic.
METHODS:
PROTEC, a phase 4, open-label, 12-month observational study, assessed annualized relapse rate (ARR), proportion of patients relapsed, and changes in PROs. Newly diagnosed and early MS (≤3.5 EDSS and ≤1 relapse in the prior year) patient subgroups were evaluated.
RESULTS:
Unadjusted ARR at 12 months post-DMF versus 12 months before DMF initiation was 75% lower (0.161 vs. 0.643, p < 0.0001) overall (n = 1105) and 84%, 77%, and 71% lower in newly diagnosed, ≤3.5 EDSS, and ≤1 relapse subgroups, respectively. Overall, 88% of patients were relapse-free 12 months after DMF initiation (84%, newly diagnosed; 88%, ≤3.5 EDSS; 88%, ≤1 relapse). PRO measures for fatigue, treatment satisfaction, daily living, and work improved significantly over 12 months of DMF versus baseline.
CONCLUSION:
At 12 months after versus 12 months before DMF initiation, ARR was significantly lower, the majority of patients were relapse-free, and multiple PRO measures showed improvement (overall and for subgroups), suggesting that DMF is effective based on clinical outcomes and from a patient perspective.Clinical trial: A Study Evaluating the Effectiveness of Tecfidera (Dimethyl Fumarate) on Multiple Sclerosis (MS) Disease Activity and Patient-Reported Outcomes (PROTEC), NCT01930708,info:eu-repo/semantics/publishedVersio
Outros recursos marinhos
The paper describes marine fish resources living in Mozambican waters. Resource data on distribution areas, reproduction, age, growth and stock size are described. Actual price of the commercially exploited stocks are also given. The problems involving the assessment of catch areas are discussed
WAVE : a virtual audio environment: an immersive musical instrument using a low cost technological system
The WAVE project proposes a multidisciplinary
investigation in order to create a model-prototype of a virtual immersive instrument using audio, visual technologies, and virtual reality. This model will open up new horizons for the processes involved in music making by dealing not only with relevant technological issues, but especially with meaningful research in theareas of human-machine interaction and sound
@rtec: art and technology in the cultural industries
The @rtec project – Art and Technology in the Cultural Industries – is co-financed by InterReg IIIA and its partners are the Bienal de Vila Nova de Cerveira (Biennial of Vila Nova de Cerveira), the Centro Cultural de Deputación de Ourense (Cultural Centre of the Municipal Council of Ourense), the Universities of Minho and Vigo, the Câmara Municipal de Vila Nova de Cerveira (Municipal Council of Vila Nova de Cerveira), and the Centro de Computação Gráfica (Centre of Computer Graphics). The aim of the project is to strengthen and accomplish their objective of cultural
cooperation and development, both technological and formative, in order to reduce the disparity between the border regions and the big urban centres
Olhando a morte dos outros
Com especial propensão para o desenvolvimento de uma racionalidade emotiva, os media têm hoje uma particular vocação para nos fazer olhar a morte. Tão intensa como a própria vida, a morte impõe-se nos media por um “fazer-se sentir”, um imperativo de participação colectiva na dor alheia. A mediatização da agonia de João Paulo II é apenas o pretexto para um trabalho que pretende, acima de tudo, interrogar o carácter de noticiabilidade da morte
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