A fractional notion of length and an associated nonlocal curvature

Here a new notion of fractional length of a smooth curve, which depends on a parameter $\sigma$, is introduced that is analogous to the fractional perimeter functional of sets that has been studied in recent years. It is shown that in an appropriate limit the fractional length converges to the traditional notion of length up to a multiplicative constant. Since a curve that connects two points of minimal length must have zero curvature, the Euler--Lagrange equation associated with the fractional length is used to motivate a nonlocal notion of curvature for a curve. This is analogous to how the fractional perimeter has been used to define a nonlocal mean curvature.Comment: 20 pages, 3 figure

On the Number of Clumps Resulting from the Overlap of Randomly Placed Figures in a Plane

When two-dimensional figures, called laminae, are randomly placed on a plane domains result that can either be aggregates or individual laminae. The intersection of the union, U, of these domains with a specified field of view, F, in the plane is considered. The separate elements of the intersection are called clumps; they may be laminae, aggregates or partial laminae and aggregates. A formula is derived for the expected number of clumps minus enclosed voids. For bounded laminae homeomorphic to a closed disc with isotropic random direction the formula contains only their mean area and mean perimeter, the area and perimeter of F, and the intensity of the Poisson process

Punctured polygons and polyominoes on the square lattice

We use the finite lattice method to count the number of punctured staircase and self-avoiding polygons with up to three holes on the square lattice. New or radically extended series have been derived for both the perimeter and area generating functions. We show that the critical point is unchanged by a finite number of punctures, and that the critical exponent increases by a fixed amount for each puncture. The increase is 1.5 per puncture when enumerating by perimeter and 1.0 when enumerating by area. A refined estimate of the connective constant for polygons by area is given. A similar set of results is obtained for finitely punctured polyominoes. The exponent increase is proved to be 1.0 per puncture for polyominoes.Comment: 36 pages, 11 figure

Exact solution of two classes of prudent polygons

Prudent walks are self-avoiding walks on the square lattice which never step into the direction of an already occupied vertex. We study the closed version of these walks, called prudent polygons, where the last vertex is adjacent to the first one. More precisely, we give the half-perimeter generating functions of two subclasses of prudent polygons, which turn out to be algebraic and non-D-finite, respectively.Comment: 11 pages, 3 figures; 14 pages, 4 figures, improved exposition, additional figure; 23 pages, 12 figures, additional section and figure

Incorporating chemical signalling factors into cell-based models of growing epithelial tissues

In this paper we present a comprehensive computational framework within which the effects of chemical signalling factors on growing epithelial tissues can be studied. The method incorporates a vertex-based cell model, in conjunction with a solver for the governing chemical equations. The vertex model provides a natural mesh for the finite element method (FEM), with node movements determined by force laws. The arbitrary Lagrangian–Eulerian formulation is adopted to account for domain movement between iterations. The effects of cell proliferation and junctional rearrangements on the mesh are also examined. By implementing refinements of the mesh we show that the finite element (FE) approximation converges towards an accurate numerical solution. The potential utility of the system is demonstrated in the context of Decapentaplegic (Dpp), a morphogen which plays a crucial role in development of the Drosophila imaginal wing disc. Despite the presence of a Dpp gradient, growth is uniform across the wing disc. We make the growth rate of cells dependent on Dpp concentration and show that the number of proliferation events increases in regions of high concentration. This allows hypotheses regarding mechanisms of growth control to be rigorously tested. The method we describe may be adapted to a range of potential application areas, and to other cell-based models with designated node movements, to accurately probe the role of morphogens in epithelial tissues