Sparse feature learning for image analysis in segmentation, classification, and disease diagnosis.

The success of machine learning algorithms generally depends on intermediate data representation, called features that disentangle the hidden factors of variation in data. Moreover, machine learning models are required to be generalized, in order to reduce the specificity or bias toward the training dataset. Unsupervised feature learning is useful in taking advantage of large amount of unlabeled data, which is available to capture these variations. However, learned features are required to capture variational patterns in data space. In this dissertation, unsupervised feature learning with sparsity is investigated for sparse and local feature extraction with application to lung segmentation, interpretable deep models, and Alzheimer\u27s disease classification. Nonnegative Matrix Factorization, Autoencoder and 3D Convolutional Autoencoder are used as architectures or models for unsupervised feature learning. They are investigated along with nonnegativity, sparsity and part-based representation constraints for generalized and transferable feature extraction

Cancer diagnosis using deep learning: A bibliographic review

In this paper, we first describe the basics of the field of cancer diagnosis, which includes steps of cancer diagnosis followed by the typical classification methods used by doctors, providing a historical idea of cancer classification techniques to the readers. These methods include Asymmetry, Border, Color and Diameter (ABCD) method, seven-point detection method, Menzies method, and pattern analysis. They are used regularly by doctors for cancer diagnosis, although they are not considered very efficient for obtaining better performance. Moreover, considering all types of audience, the basic evaluation criteria are also discussed. The criteria include the receiver operating characteristic curve (ROC curve), Area under the ROC curve (AUC), F1 score, accuracy, specificity, sensitivity, precision, dice-coefficient, average accuracy, and Jaccard index. Previously used methods are considered inefficient, asking for better and smarter methods for cancer diagnosis. Artificial intelligence and cancer diagnosis are gaining attention as a way to define better diagnostic tools. In particular, deep neural networks can be successfully used for intelligent image analysis. The basic framework of how this machine learning works on medical imaging is provided in this study, i.e., pre-processing, image segmentation and post-processing. The second part of this manuscript describes the different deep learning techniques, such as convolutional neural networks (CNNs), generative adversarial models (GANs), deep autoencoders (DANs), restricted Boltzmann’s machine (RBM), stacked autoencoders (SAE), convolutional autoencoders (CAE), recurrent neural networks (RNNs), long short-term memory (LTSM), multi-scale convolutional neural network (M-CNN), multi-instance learning convolutional neural network (MIL-CNN). For each technique, we provide Python codes, to allow interested readers to experiment with the cited algorithms on their own diagnostic problems. The third part of this manuscript compiles the successfully applied deep learning models for different types of cancers. Considering the length of the manuscript, we restrict ourselves to the discussion of breast cancer, lung cancer, brain cancer, and skin cancer. The purpose of this bibliographic review is to provide researchers opting to work in implementing deep learning and artificial neural networks for cancer diagnosis a knowledge from scratch of the state-of-the-art achievements

Self-Supervised Blind Source Separation via Multi-Encoder Autoencoders

The task of blind source separation (BSS) involves separating sources from a mixture without prior knowledge of the sources or the mixing system. This is a challenging problem that often requires making restrictive assumptions about both the mixing system and the sources. In this paper, we propose a novel method for addressing BSS of non-linear mixtures by leveraging the natural feature subspace specialization ability of multi-encoder autoencoders with fully self-supervised learning without strong priors. During the training phase, our method unmixes the input into the separate encoding spaces of the multi-encoder network and then remixes these representations within the decoder for a reconstruction of the input. Then to perform source inference, we introduce a novel encoding masking technique whereby masking out all but one of the encodings enables the decoder to estimate a source signal. To this end, we also introduce a so-called pathway separation loss that encourages sparsity between the unmixed encoding spaces throughout the decoder's layers and a so-called zero reconstruction loss on the decoder for coherent source estimations. In order to carefully evaluate our method, we conduct experiments on a toy dataset and with real-world biosignal recordings from a polysomnography sleep study for extracting respiration.Comment: 17 pages, 8 figures, submitted to Information Science

Latent Class Model with Application to Speaker Diarization

In this paper, we apply a latent class model (LCM) to the task of speaker diarization. LCM is similar to Patrick Kenny's variational Bayes (VB) method in that it uses soft information and avoids premature hard decisions in its iterations. In contrast to the VB method, which is based on a generative model, LCM provides a framework allowing both generative and discriminative models. The discriminative property is realized through the use of i-vector (Ivec), probabilistic linear discriminative analysis (PLDA), and a support vector machine (SVM) in this work. Systems denoted as LCM-Ivec-PLDA, LCM-Ivec-SVM, and LCM-Ivec-Hybrid are introduced. In addition, three further improvements are applied to enhance its performance. 1) Adding neighbor windows to extract more speaker information for each short segment. 2) Using a hidden Markov model to avoid frequent speaker change points. 3) Using an agglomerative hierarchical cluster to do initialization and present hard and soft priors, in order to overcome the problem of initial sensitivity. Experiments on the National Institute of Standards and Technology Rich Transcription 2009 speaker diarization database, under the condition of a single distant microphone, show that the diarization error rate (DER) of the proposed methods has substantial relative improvements compared with mainstream systems. Compared to the VB method, the relative improvements of LCM-Ivec-PLDA, LCM-Ivec-SVM, and LCM-Ivec-Hybrid systems are 23.5%, 27.1%, and 43.0%, respectively. Experiments on our collected database, CALLHOME97, CALLHOME00 and SRE08 short2-summed trial conditions also show that the proposed LCM-Ivec-Hybrid system has the best overall performance