A Novel Algorithm for Cooperative Distributed Sequential Spectrum Sensing in Cognitive Radio

This paper considers cooperative spectrum sensing in Cognitive Radios. In our previous work we have developed DualSPRT, a distributed algorithm for cooperative spectrum sensing using Sequential Probability Ratio Test (SPRT) at the Cognitive Radios as well as at the fusion center. This algorithm works well, but is not optimal. In this paper we propose an improved algorithm- SPRT-CSPRT, which is motivated from Cumulative Sum Procedures (CUSUM). We analyse it theoretically. We also modify this algorithm to handle uncertainties in SNR's and fading.Comment: This paper has been withdrawn by the author due to the submission of detailed journal version of the same paper, to arXi

Distributed Nonparametric Sequential Spectrum Sensing under Electromagnetic Interference

A nonparametric distributed sequential algorithm for quick detection of spectral holes in a Cognitive Radio set up is proposed. Two or more local nodes make decisions and inform the fusion centre (FC) over a reporting Multiple Access Channel (MAC), which then makes the final decision. The local nodes use energy detection and the FC uses mean detection in the presence of fading, heavy-tailed electromagnetic interference (EMI) and outliers. The statistics of the primary signal, channel gain or the EMI is not known. Different nonparametric sequential algorithms are compared to choose appropriate algorithms to be used at the local nodes and the FC. Modification of a recently developed random walk test is selected for the local nodes for energy detection as well as at the fusion centre for mean detection. It is shown via simulations and analysis that the nonparametric distributed algorithm developed performs well in the presence of fading, EMI and is robust to outliers. The algorithm is iterative in nature making the computation and storage requirements minimal.Comment: 8 pages; 6 figures; Version 2 has the proofs for the theorems. Version 3 contains a new section on approximation analysi

On optimal designs for clinical trials: An updated review

Optimization of clinical trial designs can help investigators achieve higher qualityresults for the given resource constraints. The present paper gives an overviewof optimal designs for various important problems that arise in different stages ofclinical drug development, including phase I dose–toxicity studies; phase I/II studiesthat consider early efficacy and toxicity outcomes simultaneously; phase IIdose–response studies driven by multiple comparisons (MCP), modeling techniques(Mod), or their combination (MCP–Mod); phase III randomized controlled multiarmmulti-objective clinical trials to test difference among several treatment groups;and population pharmacokinetics–pharmacodynamics experiments. We find thatmodern literature is very rich with optimal design methodologies that can be utilizedby clinical researchers to improve efficiency of drug development