4,529 research outputs found
Machine Learning and Integrative Analysis of Biomedical Big Data.
Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues
Recent Advances and Applications of Fractional-Order Neural Networks
This paper focuses on the growth, development, and future of various forms of fractional-order neural networks. Multiple advances in structure, learning algorithms, and methods have been critically investigated and summarized. This also includes the recent trends in the dynamics of various fractional-order neural networks. The multiple forms of fractional-order neural networks considered in this study are Hopfield, cellular, memristive, complex, and quaternion-valued based networks. Further, the application of fractional-order neural networks in various computational fields such as system identification, control, optimization, and stability have been critically analyzed and discussed
Hybrid model using logit and nonparametric methods for predicting micro-entity failure
Following the calls from literature on bankruptcy, a parsimonious hybrid bankruptcy model is developed in this paper
by combining parametric and non-parametric approaches.To this end, the variables with the highest predictive power to
detect bankruptcy are selected using logistic regression (LR). Subsequently, alternative non-parametric methods
(Multilayer Perceptron, Rough Set, and Classification-Regression Trees) are applied, in turn, to firms classified as
either “bankrupt” or “not bankrupt”. Our findings show that hybrid models, particularly those combining LR and
Multilayer Perceptron, offer better accuracy performance and interpretability and converge faster than each method
implemented in isolation. Moreover, the authors demonstrate that the introduction of non-financial and macroeconomic
variables complement financial ratios for bankruptcy prediction
An empirical learning-based validation procedure for simulation workflow
Simulation workflow is a top-level model for the design and control of
simulation process. It connects multiple simulation components with time and
interaction restrictions to form a complete simulation system. Before the
construction and evaluation of the component models, the validation of
upper-layer simulation workflow is of the most importance in a simulation
system. However, the methods especially for validating simulation workflow is
very limit. Many of the existing validation techniques are domain-dependent
with cumbersome questionnaire design and expert scoring. Therefore, this paper
present an empirical learning-based validation procedure to implement a
semi-automated evaluation for simulation workflow. First, representative
features of general simulation workflow and their relations with validation
indices are proposed. The calculation process of workflow credibility based on
Analytic Hierarchy Process (AHP) is then introduced. In order to make full use
of the historical data and implement more efficient validation, four learning
algorithms, including back propagation neural network (BPNN), extreme learning
machine (ELM), evolving new-neuron (eNFN) and fast incremental gaussian mixture
model (FIGMN), are introduced for constructing the empirical relation between
the workflow credibility and its features. A case study on a landing-process
simulation workflow is established to test the feasibility of the proposed
procedure. The experimental results also provide some useful overview of the
state-of-the-art learning algorithms on the credibility evaluation of
simulation models
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