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Neural masses and fields: modeling the dynamics of brain activity
This technical note introduces a conductance-based neural field model that combines biologically realistic synaptic dynamics—based on transmembrane currents—with neural field equations, describing the propagation of spikes over the cortical surface. This model allows for fairly realistic inter-and intra-laminar intrinsic connections that underlie spatiotemporal neuronal dynamics. We focus on the response functions of expected neuronal states (such as depolarization) that generate observed electrophysiological signals (like LFP recordings and EEG). These response functions characterize the model's transfer functions and implicit spectral responses to (uncorrelated) input. Our main finding is that both the evoked responses (impulse response functions) and induced responses (transfer functions) show qualitative differences depending upon whether one uses a neural mass or field model. Furthermore, there are differences between the equivalent convolution and conductance models. Overall, all models reproduce a characteristic increase in frequency, when inhibition was increased by increasing the rate constants of inhibitory populations. However, convolution and conductance-based models showed qualitatively different changes in power, with convolution models showing decreases with increasing inhibition, while conductance models show the opposite effect. These differences suggest that conductance based field models may be important in empirical studies of cortical gain control or pharmacological manipulations
Neural mass modeling of power-line magnetic fields effects on brain activity
Neural mass models are an appropriate framework to study brain activity, combining a high degree of biological realism while being mathematically tractable. These models have been used, with a certain success, to simulate brain electric (electroencephalography, EEG) and metabolic (functional magnetic resonance imaging, fMRI) activity. However, concrete applications of neural mass models have remained limited to date. Motivated by experimental results obtained in humans, we propose in this paper a neural mass model designed to study the interaction between power-line magnetic fields (MFs) (60 Hz in North America) and brain activity. The model includes pyramidal cells; dendrite-projecting, slow GABAergic neurons; soma-projecting, fast GABAergic neurons; and glutamatergic interneurons. A simple phenomenological model of interaction between the induced electric field and neuron membranes is also considered, along with a model of post-synaptic calcium concentration and associated changes in synaptic weights Simulated EEG signals are produced in a simple protocol, both in the absence and presence of a 60 Hz MF. These results are discussed based on results obtained previously in humans. Notably, results highlight that (1) EEG alpha (8–12 Hz) power can be modulated by weak membrane depolarizations induced by the exposure; (2) the level of input noise has a significant impact on EEG power modulation; and (3) the threshold value in MF flux density resulting in a significant effect on the EEG depends on the type of neuronal populations modulated by the MF exposure. Results obtained from the model shed new light on the effects of power-line MFs on brain activity, and will provide guidance in future human experiments. This may represent a valuable contribution to international regulation agencies setting guidelines on MF values to which the general public and workers can be exposed
Neural mass modeling of power-line magnetic fields effects on brain activity
Neural mass models are an appropriate framework to study brain activity, combining a high degree of biological realism while being mathematically tractable. These models have been used, with a certain success, to simulate brain electric (electroencephalography, EEG) and metabolic (functional magnetic resonance imaging, fMRI) activity. However, concrete applications of neural mass models have remained limited to date. Motivated by experimental results obtained in humans, we propose in this paper a neural mass model designed to study the interaction between power-line magnetic fields (60 Hz in North America) and brain activity. The model includes pyramidal cells; dendrite-projecting, slow GABAergic neurons; soma-projecting, fast GABAergic neurons; and glutamatergic interneurons. A simple phenomenological model of interaction between the induced electric field and neuron membranes is also considered, along with a model of post-synaptic calcium concentration and associated changes in synaptic weights Simulated EEG signals are produced in a simple protocol, both in the absence and presence of a 60 Hz magnetic field. These results are discussed based on results obtained previously in humans. Notably, results highlight that 1) EEG alpha (8-12 Hz) power can be modulated by weak membrane depolarizations induced by the exposure; 2) the level of input noise has a significant impact on EEG alpha power modulation; and 3) neural mass network size results in a different alpha rhythm modulation than when an individual neural mass is considered. Results obtained from the model shed new light on the effects of power-line magnetic fields on brain activity, and will provide guidance in future human experiments. This may represent a valuable contribution to international regulation agencies setting guidelines on magnetic field values to which the general public and workers can be exposed
Impact of Extremely Low-Frequency Magnetic and Electric Stimuli on Vestibular-Driven Outcomes
The vestibular system is extremely sensitive to electric fields (E-fields). Indeed, vestibular hair cells are graded potential cells and this property makes them very susceptible to small membrane potential modulations. Studies show that extremely low-frequency magnetic fields (ELF-MF) induced E-fields impact postural control in which the vestibular system plays an important role. However, the knowledge of whether this is indeed a vestibular specific effect is still pending.
Considering its crucial role and the specific neurophysiological characteristics of its hair cells, the vestibular system emerges as an ELF-MF likely target
The three studies presented in this thesis aimed to further address whether ELF-MF modulate vestibular-driven outcomes.
Studies 1 and 2 aimed to investigate postural responses while more specifically targeting the vestibular system. However, we did not find any modulation in either study. Nonetheless, based on both studies, study 3 aimed to determine whether the orientation and frequency of our stimulations were more likely to target the otoliths. Therefore, the third study looked at the subjective visual vertical. Here, we found a potential ELF-MF utricular modulation.
This thesis is the first steppingstone in a new field of research. Further investigations regarding the interaction between the ELF-MF and the vestibular system will have to look at more reflexives vestibular outcomes. Nonetheless, this thesis provides valuable information that will need to be taken into consideration when writing future international guidelines and standards related to ELF-MF
The Largest Unethical Medical Experiment in Human History
This monograph describes the largest unethical medical experiment in human history: the implementation and operation of non-ionizing non-visible EMF radiation (hereafter called wireless radiation) infrastructure for communications, surveillance, weaponry, and other applications. It is unethical because it violates the key ethical medical experiment requirement for “informed consent” by the overwhelming majority of the participants.
The monograph provides background on unethical medical research/experimentation, and frames the implementation of wireless radiation within that context. The monograph then identifies a wide spectrum of adverse effects of wireless radiation as reported in the premier biomedical literature for over seven decades. Even though many of these reported adverse effects are extremely severe, the true extent of their severity has been grossly underestimated.
Most of the reported laboratory experiments that produced these effects are not reflective of the real-life environment in which wireless radiation operates. Many experiments do not include pulsing and modulation of the carrier signal, and most do not account for synergistic effects of other toxic stimuli acting in concert with the wireless radiation. These two additions greatly exacerbate the severity of the adverse effects from wireless radiation, and their neglect in current (and past) experimentation results in substantial under-estimation of the breadth and severity of adverse effects to be expected in a real-life situation. This lack of credible safety testing, combined with depriving the public of the opportunity to provide informed consent, contextualizes the wireless radiation infrastructure operation as an unethical medical experiment