5,742 research outputs found
SeizureNet: Multi-Spectral Deep Feature Learning for Seizure Type Classification
Automatic classification of epileptic seizure types in electroencephalograms
(EEGs) data can enable more precise diagnosis and efficient management of the
disease. This task is challenging due to factors such as low signal-to-noise
ratios, signal artefacts, high variance in seizure semiology among epileptic
patients, and limited availability of clinical data. To overcome these
challenges, in this paper, we present SeizureNet, a deep learning framework
which learns multi-spectral feature embeddings using an ensemble architecture
for cross-patient seizure type classification. We used the recently released
TUH EEG Seizure Corpus (V1.4.0 and V1.5.2) to evaluate the performance of
SeizureNet. Experiments show that SeizureNet can reach a weighted F1 score of
up to 0.94 for seizure-wise cross validation and 0.59 for patient-wise cross
validation for scalp EEG based multi-class seizure type classification. We also
show that the high-level feature embeddings learnt by SeizureNet considerably
improve the accuracy of smaller networks through knowledge distillation for
applications with low-memory constraints
Learning Representations from EEG with Deep Recurrent-Convolutional Neural Networks
One of the challenges in modeling cognitive events from electroencephalogram
(EEG) data is finding representations that are invariant to inter- and
intra-subject differences, as well as to inherent noise associated with such
data. Herein, we propose a novel approach for learning such representations
from multi-channel EEG time-series, and demonstrate its advantages in the
context of mental load classification task. First, we transform EEG activities
into a sequence of topology-preserving multi-spectral images, as opposed to
standard EEG analysis techniques that ignore such spatial information. Next, we
train a deep recurrent-convolutional network inspired by state-of-the-art video
classification to learn robust representations from the sequence of images. The
proposed approach is designed to preserve the spatial, spectral, and temporal
structure of EEG which leads to finding features that are less sensitive to
variations and distortions within each dimension. Empirical evaluation on the
cognitive load classification task demonstrated significant improvements in
classification accuracy over current state-of-the-art approaches in this field.Comment: To be published as a conference paper at ICLR 201
Seizure-onset mapping based on time-variant multivariate functional connectivity analysis of high-dimensional intracranial EEG : a Kalman filter approach
The visual interpretation of intracranial EEG (iEEG) is the standard method used in complex epilepsy surgery cases to map the regions of seizure onset targeted for resection. Still, visual iEEG analysis is labor-intensive and biased due to interpreter dependency. Multivariate parametric functional connectivity measures using adaptive autoregressive (AR) modeling of the iEEG signals based on the Kalman filter algorithm have been used successfully to localize the electrographic seizure onsets. Due to their high computational cost, these methods have been applied to a limited number of iEEG time-series (< 60). The aim of this study was to test two Kalman filter implementations, a well-known multivariate adaptive AR model (Arnold et al. 1998) and a simplified, computationally efficient derivation of it, for their potential application to connectivity analysis of high-dimensional (up to 192 channels) iEEG data. When used on simulated seizures together with a multivariate connectivity estimator, the partial directed coherence, the two AR models were compared for their ability to reconstitute the designed seizure signal connections from noisy data. Next, focal seizures from iEEG recordings (73-113 channels) in three patients rendered seizure-free after surgery were mapped with the outdegree, a graph-theory index of outward directed connectivity. Simulation results indicated high levels of mapping accuracy for the two models in the presence of low-to-moderate noise cross-correlation. Accordingly, both AR models correctly mapped the real seizure onset to the resection volume. This study supports the possibility of conducting fully data-driven multivariate connectivity estimations on high-dimensional iEEG datasets using the Kalman filter approach
Topological exploration of artificial neuronal network dynamics
One of the paramount challenges in neuroscience is to understand the dynamics
of individual neurons and how they give rise to network dynamics when
interconnected. Historically, researchers have resorted to graph theory,
statistics, and statistical mechanics to describe the spatiotemporal structure
of such network dynamics. Our novel approach employs tools from algebraic
topology to characterize the global properties of network structure and
dynamics.
We propose a method based on persistent homology to automatically classify
network dynamics using topological features of spaces built from various
spike-train distances. We investigate the efficacy of our method by simulating
activity in three small artificial neural networks with different sets of
parameters, giving rise to dynamics that can be classified into four regimes.
We then compute three measures of spike train similarity and use persistent
homology to extract topological features that are fundamentally different from
those used in traditional methods. Our results show that a machine learning
classifier trained on these features can accurately predict the regime of the
network it was trained on and also generalize to other networks that were not
presented during training. Moreover, we demonstrate that using features
extracted from multiple spike-train distances systematically improves the
performance of our method
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