Near-critical fluctuations and cytoskeleton-assisted phase separation lead to subdiffusion in cell membranes

We address the relationship between membrane microheterogeneity and anomalous subdiffusion in cell membranes by carrying out Monte Carlo simulations of two-component lipid membranes. We find that near-critical fluctuations in the membrane lead to transient subdiffusion, while membrane-cytoskeleton interaction strongly affects phase separation, enhances subdiffusion, and eventually leads to hop diffusion of lipids. Thus, we present a minimum realistic model for membrane rafts showing the features of both microscopic phase separation and subdiffusion.Comment: 21 pages, 5 figures; Supporting Material 5 pages, 1 figure, 1 tabl

Individualized Rank Aggregation using Nuclear Norm Regularization

In recent years rank aggregation has received significant attention from the machine learning community. The goal of such a problem is to combine the (partially revealed) preferences over objects of a large population into a single, relatively consistent ordering of those objects. However, in many cases, we might not want a single ranking and instead opt for individual rankings. We study a version of the problem known as collaborative ranking. In this problem we assume that individual users provide us with pairwise preferences (for example purchasing one item over another). From those preferences we wish to obtain rankings on items that the users have not had an opportunity to explore. The results here have a very interesting connection to the standard matrix completion problem. We provide a theoretical justification for a nuclear norm regularized optimization procedure, and provide high-dimensional scaling results that show how the error in estimating user preferences behaves as the number of observations increase

Synchronized Oscillations During Cooperative Feature Linking in a Cortical Model of Visual Perception

A neural network model of synchronized oscillator activity in visual cortex is presented in order to account for recent neurophysiological findings that such synchronization may reflect global properties of the stimulus. In these recent experiments, it was reported that synchronization of oscillatory firing responses to moving bar stimuli occurred not only for nearby neurons, but also occurred between neurons separated by several cortical columns (several mm of cortex) when these neurons shared some receptive field preferences specific to the stimuli. These results were obtained not only for single bar stimuli but also across two disconnected, but colinear, bars moving in the same direction. Our model and computer simulations obtain these synchrony results across both single and double bar stimuli. For the double bar case, synchronous oscillations are induced in the region between the bars, but no oscillations are induced in the regions beyond the stimuli. These results were achieved with cellular units that exhibit limit cycle oscillations for a robust range of input values, but which approach an equilibrium state when undriven. Single and double bar synchronization of these oscillators was achieved by different, but formally related, models of preattentive visual boundary segmentation and attentive visual object recognition, as well as nearest-neighbor and randomly coupled models. In preattentive visual segmentation, synchronous oscillations may reflect the binding of local feature detectors into a globally coherent grouping. In object recognition, synchronous oscillations may occur during an attentive resonant state that triggers new learning. These modelling results support earlier theoretical predictions of synchronous visual cortical oscillations and demonstrate the robustness of the mechanisms capable of generating synchrony.Air Force Office of Scientific Research (90-0175); Army Research Office (DAAL-03-88-K0088); Defense Advanced Research Projects Agency (90-0083); National Aeronautics and Space Administration (NGT-50497

A Harmonic Extension Approach for Collaborative Ranking

We present a new perspective on graph-based methods for collaborative ranking for recommender systems. Unlike user-based or item-based methods that compute a weighted average of ratings given by the nearest neighbors, or low-rank approximation methods using convex optimization and the nuclear norm, we formulate matrix completion as a series of semi-supervised learning problems, and propagate the known ratings to the missing ones on the user-user or item-item graph globally. The semi-supervised learning problems are expressed as Laplace-Beltrami equations on a manifold, or namely, harmonic extension, and can be discretized by a point integral method. We show that our approach does not impose a low-rank Euclidean subspace on the data points, but instead minimizes the dimension of the underlying manifold. Our method, named LDM (low dimensional manifold), turns out to be particularly effective in generating rankings of items, showing decent computational efficiency and robust ranking quality compared to state-of-the-art methods

Just Sort It! A Simple and Effective Approach to Active Preference Learning

We address the problem of learning a ranking by using adaptively chosen pairwise comparisons. Our goal is to recover the ranking accurately but to sample the comparisons sparingly. If all comparison outcomes are consistent with the ranking, the optimal solution is to use an efficient sorting algorithm, such as Quicksort. But how do sorting algorithms behave if some comparison outcomes are inconsistent with the ranking? We give favorable guarantees for Quicksort for the popular Bradley-Terry model, under natural assumptions on the parameters. Furthermore, we empirically demonstrate that sorting algorithms lead to a very simple and effective active learning strategy: repeatedly sort the items. This strategy performs as well as state-of-the-art methods (and much better than random sampling) at a minuscule fraction of the computational cost.Comment: Accepted at ICML 201

Evaluating Cartogram Effectiveness

Cartograms are maps in which areas of geographic regions (countries, states) appear in proportion to some variable of interest (population, income). Cartograms are popular visualizations for geo-referenced data that have been used for over a century and that make it possible to gain insight into patterns and trends in the world around us. Despite the popularity of cartograms and the large number of cartogram types, there are few studies evaluating the effectiveness of cartograms in conveying information. Based on a recent task taxonomy for cartograms, we evaluate four major different types of cartograms: contiguous, non-contiguous, rectangular, and Dorling cartograms. Specifically, we evaluate the effectiveness of these cartograms by quantitative performance analysis, as well as by subjective preferences. We analyze the results of our study in the context of some prevailing assumptions in the literature of cartography and cognitive science. Finally, we make recommendations for the use of different types of cartograms for different tasks and settings

How Does the Low-Rank Matrix Decomposition Help Internal and External Learnings for Super-Resolution

Wisely utilizing the internal and external learning methods is a new challenge in super-resolution problem. To address this issue, we analyze the attributes of two methodologies and find two observations of their recovered details: 1) they are complementary in both feature space and image plane, 2) they distribute sparsely in the spatial space. These inspire us to propose a low-rank solution which effectively integrates two learning methods and then achieves a superior result. To fit this solution, the internal learning method and the external learning method are tailored to produce multiple preliminary results. Our theoretical analysis and experiment prove that the proposed low-rank solution does not require massive inputs to guarantee the performance, and thereby simplifying the design of two learning methods for the solution. Intensive experiments show the proposed solution improves the single learning method in both qualitative and quantitative assessments. Surprisingly, it shows more superior capability on noisy images and outperforms state-of-the-art methods