A multidisciplinary survey of modeling techniques for biochemical networks

All processes of life are dominated by networks of interacting biochemical components. The purpose of modeling these networks is manifold. From a theoretical point of view it allows the exploration of network structures and dynamics, to find emergent properties or to explain the organization and evolution of networks. From a practical point of view, in silico experiments can be performed that would be very expensive or impossible to achieve in the laboratory, such as hypothesis-testing with regard to knockout experiments or overexpression, or checking the validity of a proposed molecular mechanism. The literature on modeling biochemical networks is growing rapidly and the motivations behind different modeling techniques are sometimes quite distant from each other. To clarify the current context, we present a systematic overview of the different philosophies to model biochemical networks. We put particular emphasis on three main domains which have been playing a major role in the past, namely: mathematics with ordinary and partial differential equations, statistics with stochastic simulation algorithms, Bayesian networks and Markov chains, and the field of computer science with process calculi, term rewriting systems and state based systems. For each school, we evaluate advantages and disadvantages such as the granularity of representation, scalability, accessibility or availability of analysis tools. Following this, we describe how one can combine some of those techniques and thus take advantages of several techniques through the use of bridging tools. Finally, we propose a next step for modeling biochemical networks by using artificial chemistries and evolutionary computation. This work was funded by ESIGNET (Evolving Cell Signaling Networks in Silico), an European Integrated Project in the EU FP6 NEST Initiative (contract no. 12789)

GA Based Robust Blind Digital Watermarking

A genetic algorithm based robust blind digital watermarking scheme is presented. The experimental results show that our scheme keeps invisibility, security and robustness more likely than other proposals in the literature, thanks to the GA pretreatment.Junta de Andalucía FQM-01

The DBSCAN Clustering Algorithm on P Systems

We show how to implement the DBSCAN clustering algorithm (Density Based Spatial Clustering of Applications with Noise) on membrane systems using evolution rules with promoters and priorities

Testing approaches for global optimization of space trajectories

In this paper, the procedures to test global search algorithms applied to space trajectory design problems are discussed. Furthermore, a number of performance indexes that can be used to evaluate the effectiveness of the tested algorithms are presented. The performance indexes are then compared and the actual significance of each one of them is highlighted. Three global optimization algorithms are tested on three typical space trajectory design problems