Patents vs Trade Secrets: Knowledge Licensing and Spillover

We develop a model of two-stage cumulative research and development (R&D), in which one Research Unit (RU) with an innovative idea bargains to license her nonverifiable interim knowledge exclusively to one of two competing Development Units (DUs) via one of two alternative modes: an Open sale after patenting this knowledge, or a Closed sale in which precluding further disclosure to a competing DU requires the RU to hold a stake in the licensed DU’s post-invention revenues. Both modes lead to partial leakage of RU’s knowledge from its description, to the licensed DU alone in a closed sale, and to both DUs in an open sale. The open sale is socially optimal; yet the contracting parties choose the closed sale whenever the interim knowledge is more valuable and leakage is sufficiently high. If the extent of leakage is lower, more RUs choose open sales, generating a non-monotonic relationship between the strength of Intellectual Property Rights (IPR) and aggregate R&D expenditures and the overall likelihood of development by either DU.

The application of multiplex fluorimetric sensor for the analysis of flavonoids content in the medicinal herbs family Asteraceae, Lamiaceae, Rosaceae

BACKGROUND: The aim of our research work was to quantify total flavonoid contents in the leaves of 13 plant species family Asteraceae, 8 representatives of family Lamiaceae and 9 plant species belonging to familyRosaceae, using the multiplex fluorimetric sensor. Fluorescence was measured using optical fluorescence apparatus Multiplex(R) 3 (Force-A, France) for non-destructive flavonoids estimation. The content of total flavonoids was estimated by FLAV index (expressed in relative units), that is deduced from flavonoids UV absorbing properties. RESULTS: Among observed plant species, the highest amount of total flavonoids has been found in leaves ofHelianthus multiflorus (1.65 RU) and Echinops ritro (1.27 RU), Rudbeckia fulgida (1.13 RU) belonging to the family Asteraceae. Lowest flavonoid content has been observed in the leaves of marigold (Calendula officinalis) (0.14 RU) also belonging to family Asteraceae. The highest content of flavonoids among experimental plants of family Rosaceae has been estimated in the leaves of Rosa canina (1.18 RU) and among plant species of family Lamiaceae in the leaves of Coleus blumei (0.90 RU). CONCLUSIONS: This research work was done as pre-screening of flavonoids content in the leaves of plant species belonging to family Asteraceae, Lamiaceae and Rosaceae. Results indicated that statistically significant differences (P > 0.05) in flavonoids content were observed not only between families, but also among individual plant species within one family

Knowledge Disclosure, Patents and Optimal Organization of Research and Development

We develop a model of two-stage cumulative research and development (R&D), in which one Research Unit (RU) with an innovative idea bargains to license her nonverifiable interim knowledge exclusively to one of two competing Development Units (DUs) via one of two alternative modes: an Open sale after patenting this interim knowledge, or a Closed sale in which precluding further disclosure to a competing DU requires the RU to hold a stake in the licensed DU's post-invention revenues. Both models lead to partial leakage of RU's knowledge from it's description, to the licensed DU alone in a closed sale, and to both DUs in an open sale. We find that higher levels of interim knowledge are more likely to be licensed via closed sales. If the extent of leakage is lower, more RUs choose open sales, generating a non-monotonic relationship between the strength of Intellectual Property Rights (IPR) and aggregate R&D expenditures. We also develop a rationale for the ex ante acquisition of control rights over the RU by a DU, rooted in the RU's incentives to create knowledge under alternative modes of sale thereof, and her wealth constraint in ex interim bargaining.R&D organisation, patents, intellectual property rights

High School–University Collaborations for Latinx Student Success: Navigating the Political Reality

Latinx students are a growing population in postsecondary education but attain degrees at a pace behind their non-Latinx peers. This research examines a partnership between a research university (RU) and career and technical education (CTE) high school, Hillside Technical High School (HTHS). Through a 2-year ethnographic case study, we found that different logistics and cultural values were primary contributors to the bifurcated pathway between high school and college. These pathways were most successfully connected through strategies such as flexibility, personal relationships, and incorporation of community resources as well as viewing the students as resources. Our study suggests a need to reframe partnerships in recognition of the assets that students bring to these e orts, while also creating opportunities for additional faculty support and community involvement

Photoinduced electron transfer in supramolecular ruthenium-porphyrin assemblies

EZ-C acknowledges the University of St Andrews and EPSRC (EP/M02105X/1) for financial support. DE thanks funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 700961. DJ acknowledges the European Research Council (grant: 278845) and the RFI Lumomat for financial support.We present dynamic supramolecular systems composed of a Ru(II) complex of the form of [Ru(dtBubpy)2(qpy)][PF6]2 (where dtBubpy is 4,4′-di-tert-butyl-2,2′-dipyridyl and qpy is 4,4':2',2'':4'',4'''-quaterpyridine) and zinc tetraphenylporphyrins (ZnTPP), through non- covalent interactions between the distal pyridine moieties of the qpy ligand the zinc of ZnTPP. The optoelectronic properties of the assemblies and the electronic interactions between the chromophoric units have been comprehensively characterized by computational investigations, and steady-state and time-resolved emission spectroscopy. Upon photoexcitation of ZnTPP, electron transfer to the ruthenium center is thermodynamically favorable and, as a result, strong emission quenching of both units occurs.PostprintPeer reviewe

Anti-inflammatory activity of electron-deficient organometallics

YesWe report an evaluation of the cytotoxicity of a series of electron-deficient (16-electron) half-sandwich precious metal complexes of ruthenium, osmium and iridium ([Os/Ru(η6-pcymene)( 1,2-dicarba-closo-dodecarborane-1,2-dithiolato)] (1/2), [Ir(η5-pentamethylcyclopentadiene)(1,2-dicarba-closo-dodecarborane- 1,2-dithiolato)] (3), [Os/Ru(η6-p-cymene)(benzene-1, 2-dithiolato)] (4/5) and [Ir(η5-pentamethylcyclopentadiene) (benzene-1,2-dithiolato)] (6)) towards RAW 264.7 murine macrophages and MRC-5 fibroblast cells. Complexes 3 and 6 were found to be non-cytotoxic. The anti-inflammatory activity of 1–6 was evaluated in both cell lines after nitric oxide (NO) production and inflammation response induced by bacterial endotoxin lipopolysaccharide (LPS) as the stimulus. All metal complexes were shown to exhibit dose-dependent inhibitory effects on LPS-induced NO production on both cell lines. Remarkably, the two iridium complexes 3 and 6 trigger a full anti-inflammatory response against LPS-induced NO production, which opens up new avenues for the development of non-cytotoxic anti-inflammatory drug candidates with distinct structures and solution chemistry from that of organic drugs, and as such with potential novel mechanisms of action.We thank the Royal Society (University Research Fellowship No. UF150295 to NPEB), and the University of Bradford for financial support

Impact of template backbone heterogeneity on RNA polymerase II transcription.

Variations in the sugar component (ribose or deoxyribose) and the nature of the phosphodiester linkage (3'-5' or 2'-5' orientation) have been a challenge for genetic information transfer from the very beginning of evolution. RNA polymerase II (pol II) governs the transcription of DNA into precursor mRNA in all eukaryotic cells. How pol II recognizes DNA template backbone (phosphodiester linkage and sugar) and whether it tolerates the backbone heterogeneity remain elusive. Such knowledge is not only important for elucidating the chemical basis of transcriptional fidelity but also provides new insights into molecular evolution. In this study, we systematically and quantitatively investigated pol II transcriptional behaviors through different template backbone variants. We revealed that pol II can well tolerate and bypass sugar heterogeneity sites at the template but stalls at phosphodiester linkage heterogeneity sites. The distinct impacts of these two backbone components on pol II transcription reveal the molecular basis of template recognition during pol II transcription and provide the evolutionary insight from the RNA world to the contemporary 'imperfect' DNA world. In addition, our results also reveal the transcriptional consequences from ribose-containing genomic DNA

Multi-Tenant C-RAN With Spectrum Pooling: Downlink Optimization Under Privacy Constraints

IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY, VOL. 67, NO. 11, NOVEMBER 201

A Possible Crypto-Superconducting Structure in a Superconducting Ferromagnet

We have measured the dc and ac electrical and magnetic properties in various magnetic fields of the recently reported superconducting ferromagnet RuSr2GdCu2O8. Our reversible magnetization measurements demonstrate the absence of a bulk Meissner state in the compound below the superconducting transition temperature. Several scenarios that might account for the absence of a bulk Meissner state, including the possible presence of a sponge-like non-uniform superconducting or a crypto-superconducting structure in the chemically uniform Ru-1212, have been proposed and discussed.Comment: 8 pages, 5 PNG figures, submitted to Proceedings of the 9th Japan-US Workshop on High-Tc Superconductors, Yamanashi, Japan, October 13-15, 1999; accepted for publication in Physica C (December 24, 1999