Computerized Analysis of Magnetic Resonance Images to Study Cerebral Anatomy in Developing Neonates

The study of cerebral anatomy in developing neonates is of great importance for the understanding of brain development during the early period of life. This dissertation therefore focuses on three challenges in the modelling of cerebral anatomy in neonates during brain development. The methods that have been developed all use Magnetic Resonance Images (MRI) as source data. To facilitate study of vascular development in the neonatal period, a set of image analysis algorithms are developed to automatically extract and model cerebral vessel trees. The whole process consists of cerebral vessel tracking from automatically placed seed points, vessel tree generation, and vasculature registration and matching. These algorithms have been tested on clinical Time-of- Flight (TOF) MR angiographic datasets. To facilitate study of the neonatal cortex a complete cerebral cortex segmentation and reconstruction pipeline has been developed. Segmentation of the neonatal cortex is not effectively done by existing algorithms designed for the adult brain because the contrast between grey and white matter is reversed. This causes pixels containing tissue mixtures to be incorrectly labelled by conventional methods. The neonatal cortical segmentation method that has been developed is based on a novel expectation-maximization (EM) method with explicit correction for mislabelled partial volume voxels. Based on the resulting cortical segmentation, an implicit surface evolution technique is adopted for the reconstruction of the cortex in neonates. The performance of the method is investigated by performing a detailed landmark study. To facilitate study of cortical development, a cortical surface registration algorithm for aligning the cortical surface is developed. The method first inflates extracted cortical surfaces and then performs a non-rigid surface registration using free-form deformations (FFDs) to remove residual alignment. Validation experiments using data labelled by an expert observer demonstrate that the method can capture local changes and follow the growth of specific sulcus

A Review of Codebook Models in Patch-Based Visual Object Recognition

The codebook model-based approach, while ignoring any structural aspect in vision, nonetheless provides state-of-the-art performances on current datasets. The key role of a visual codebook is to provide a way to map the low-level features into a fixed-length vector in histogram space to which standard classifiers can be directly applied. The discriminative power of such a visual codebook determines the quality of the codebook model, whereas the size of the codebook controls the complexity of the model. Thus, the construction of a codebook is an important step which is usually done by cluster analysis. However, clustering is a process that retains regions of high density in a distribution and it follows that the resulting codebook need not have discriminant properties. This is also recognised as a computational bottleneck of such systems. In our recent work, we proposed a resource-allocating codebook, to constructing a discriminant codebook in a one-pass design procedure that slightly outperforms more traditional approaches at drastically reduced computing times. In this review we survey several approaches that have been proposed over the last decade with their use of feature detectors, descriptors, codebook construction schemes, choice of classifiers in recognising objects, and datasets that were used in evaluating the proposed methods

Image processing for plastic surgery planning

This thesis presents some image processing tools for plastic surgery planning. In particular, it presents a novel method that combines local and global context in a probabilistic relaxation framework to identify cephalometric landmarks used in Maxillofacial plastic surgery. It also uses a method that utilises global and local symmetry to identify abnormalities in CT frontal images of the human body. The proposed methodologies are evaluated with the help of several clinical data supplied by collaborating plastic surgeons