Proton imaging of stochastic magnetic fields

Recent laser-plasma experiments report the existence of dynamically significant magnetic fields, whose statistical characterisation is essential for understanding the physical processes these experiments are attempting to investigate. In this paper, we show how a proton imaging diagnostic can be used to determine a range of relevant magnetic field statistics, including the magnetic-energy spectrum. To achieve this goal, we explore the properties of an analytic relation between a stochastic magnetic field and the image-flux distribution created upon imaging that field. We conclude that features of the beam's final image-flux distribution often display a universal character determined by a single, field-scale dependent parameter - the contrast parameter - which quantifies the relative size of the correlation length of the stochastic field, proton displacements due to magnetic deflections, and the image magnification. For stochastic magnetic fields, we establish the existence of four contrast regimes - linear, nonlinear injective, caustic and diffusive - under which proton-flux images relate to their parent fields in a qualitatively distinct manner. As a consequence, it is demonstrated that in the linear or nonlinear injective regimes, the path-integrated magnetic field experienced by the beam can be extracted uniquely, as can the magnetic-energy spectrum under a further statistical assumption of isotropy. This is no longer the case in the caustic or diffusive regimes. We also discuss complications to the contrast-regime characterisation arising for inhomogeneous, multi-scale stochastic fields, as well as limitations currently placed by experimental capabilities on extracting magnetic field statistics. The results presented in this paper provide a comprehensive description of proton images of stochastic magnetic fields, with applications for improved analysis of given proton-flux images.Comment: Main paper pp. 1-29; appendices pp. 30-84. 24 figures, 2 table

Nuclei/Cell Detection in Microscopic Skeletal Muscle Fiber Images and Histopathological Brain Tumor Images Using Sparse Optimizations

Nuclei/Cell detection is usually a prerequisite procedure in many computer-aided biomedical image analysis tasks. In this thesis we propose two automatic nuclei/cell detection frameworks. One is for nuclei detection in skeletal muscle fiber images and the other is for brain tumor histopathological images. For skeletal muscle fiber images, the major challenges include: i) shape and size variations of the nuclei, ii) overlapping nuclear clumps, and iii) a series of z-stack images with out-of-focus regions. We propose a novel automatic detection algorithm consisting of the following components: 1) The original z-stack images are first converted into one all-in-focus image. 2) A sufficient number of hypothetical ellipses are then generated for each nuclei contour. 3) Next, a set of representative training samples and discriminative features are selected by a two-stage sparse model. 4) A classifier is trained using the refined training data. 5) Final nuclei detection is obtained by mean-shift clustering based on inner distance. The proposed method was tested on a set of images containing over 1500 nuclei. The results outperform the current state-of-the-art approaches. For brain tumor histopathological images, the major challenges are to handle significant variations in cell appearance and to split touching cells. The proposed novel automatic cell detection consists of: 1) Sparse reconstruction for splitting touching cells. 2) Adaptive dictionary learning for handling cell appearance variations. The proposed method was extensively tested on a data set with over 2000 cells. The result outperforms other state-of-the-art algorithms with F1 score = 0.96

Pattern classification approaches for breast cancer identification via MRI: state‐of‐the‐art and vision for the future

Mining algorithms for Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCEMRI) of breast tissue are discussed. The algorithms are based on recent advances in multidimensional signal processing and aim to advance current state‐of‐the‐art computer‐aided detection and analysis of breast tumours when these are observed at various states of development. The topics discussed include image feature extraction, information fusion using radiomics, multi‐parametric computer‐aided classification and diagnosis using information fusion of tensorial datasets as well as Clifford algebra based classification approaches and convolutional neural network deep learning methodologies. The discussion also extends to semi‐supervised deep learning and self‐supervised strategies as well as generative adversarial networks and algorithms using generated confrontational learning approaches. In order to address the problem of weakly labelled tumour images, generative adversarial deep learning strategies are considered for the classification of different tumour types. The proposed data fusion approaches provide a novel Artificial Intelligence (AI) based framework for more robust image registration that can potentially advance the early identification of heterogeneous tumour types, even when the associated imaged organs are registered as separate entities embedded in more complex geometric spaces. Finally, the general structure of a high‐dimensional medical imaging analysis platform that is based on multi‐task detection and learning is proposed as a way forward. The proposed algorithm makes use of novel loss functions that form the building blocks for a generated confrontation learning methodology that can be used for tensorial DCE‐MRI. Since some of the approaches discussed are also based on time‐lapse imaging, conclusions on the rate of proliferation of the disease can be made possible. The proposed framework can potentially reduce the costs associated with the interpretation of medical images by providing automated, faster and more consistent diagnosis

Proceedings of the second "international Traveling Workshop on Interactions between Sparse models and Technology" (iTWIST'14)

The implicit objective of the biennial "international - Traveling Workshop on Interactions between Sparse models and Technology" (iTWIST) is to foster collaboration between international scientific teams by disseminating ideas through both specific oral/poster presentations and free discussions. For its second edition, the iTWIST workshop took place in the medieval and picturesque town of Namur in Belgium, from Wednesday August 27th till Friday August 29th, 2014. The workshop was conveniently located in "The Arsenal" building within walking distance of both hotels and town center. iTWIST'14 has gathered about 70 international participants and has featured 9 invited talks, 10 oral presentations, and 14 posters on the following themes, all related to the theory, application and generalization of the "sparsity paradigm": Sparsity-driven data sensing and processing; Union of low dimensional subspaces; Beyond linear and convex inverse problem; Matrix/manifold/graph sensing/processing; Blind inverse problems and dictionary learning; Sparsity and computational neuroscience; Information theory, geometry and randomness; Complexity/accuracy tradeoffs in numerical methods; Sparsity? What's next?; Sparse machine learning and inference.Comment: 69 pages, 24 extended abstracts, iTWIST'14 website: http://sites.google.com/site/itwist1

Spatial Stimuli Gradient Based Multifocus Image Fusion Using Multiple Sized Kernels

Multi-focus image fusion technique extracts the focused areas from all the source images and combines them into a new image which contains all focused objects. This paper proposes a spatial domain fusion scheme for multi-focus images by using multiple size kernels. Firstly, source images are pre-processed with a contrast enhancement step and then the soft and hard decision maps are generated by employing a sliding window technique using multiple sized kernels on the gradient images. Hard decision map selects the accurate focus information from the source images, whereas, the soft decision map selects the basic focus information and contains minimum falsely detected focused/unfocused regions. These decision maps are further processed to compute the final focus map. Gradient images are constructed through state-ofthe-art edge detection technique, spatial stimuli gradient sketch model, which computes the local stimuli from perceived brightness and hence enhances the essential structural and edge information. Detailed experiment results demonstrate that the proposed multi-focus image fusion algorithm performs better than the other well known state-of-the-art multifocus image fusion methods, in terms of subjective visual perception and objective quality evaluation metrics