Moving forward with combinatorial interaction testing

Combinatorial interaction testing (CIT) is an efficient and effective method of detecting failures that are caused by the interactions of various system input parameters. In this paper, we discuss CIT, point out some of the difficulties of applying it in practice, and highlight some recent advances that have improved CIT’s applicability to modern systems. We also provide a roadmap for future research and directions; one that we hope will lead to new CIT research and to higher quality testing of industrial systems

An Efficient Bandit Algorithm for Realtime Multivariate Optimization

Optimization is commonly employed to determine the content of web pages, such as to maximize conversions on landing pages or click-through rates on search engine result pages. Often the layout of these pages can be decoupled into several separate decisions. For example, the composition of a landing page may involve deciding which image to show, which wording to use, what color background to display, etc. Such optimization is a combinatorial problem over an exponentially large decision space. Randomized experiments do not scale well to this setting, and therefore, in practice, one is typically limited to optimizing a single aspect of a web page at a time. This represents a missed opportunity in both the speed of experimentation and the exploitation of possible interactions between layout decisions. Here we focus on multivariate optimization of interactive web pages. We formulate an approach where the possible interactions between different components of the page are modeled explicitly. We apply bandit methodology to explore the layout space efficiently and use hill-climbing to select optimal content in realtime. Our algorithm also extends to contextualization and personalization of layout selection. Simulation results show the suitability of our approach to large decision spaces with strong interactions between content. We further apply our algorithm to optimize a message that promotes adoption of an Amazon service. After only a single week of online optimization, we saw a 21% conversion increase compared to the median layout. Our technique is currently being deployed to optimize content across several locations at Amazon.com.Comment: KDD'17 Audience Appreciation Awar

Fuzzy Adaptive Tuning of a Particle Swarm Optimization Algorithm for Variable-Strength Combinatorial Test Suite Generation

Combinatorial interaction testing is an important software testing technique that has seen lots of recent interest. It can reduce the number of test cases needed by considering interactions between combinations of input parameters. Empirical evidence shows that it effectively detects faults, in particular, for highly configurable software systems. In real-world software testing, the input variables may vary in how strongly they interact, variable strength combinatorial interaction testing (VS-CIT) can exploit this for higher effectiveness. The generation of variable strength test suites is a non-deterministic polynomial-time (NP) hard computational problem \cite{BestounKamalFuzzy2017}. Research has shown that stochastic population-based algorithms such as particle swarm optimization (PSO) can be efficient compared to alternatives for VS-CIT problems. Nevertheless, they require detailed control for the exploitation and exploration trade-off to avoid premature convergence (i.e. being trapped in local optima) as well as to enhance the solution diversity. Here, we present a new variant of PSO based on Mamdani fuzzy inference system \cite{Camastra2015,TSAKIRIDIS2017257,KHOSRAVANIAN2016280}, to permit adaptive selection of its global and local search operations. We detail the design of this combined algorithm and evaluate it through experiments on multiple synthetic and benchmark problems. We conclude that fuzzy adaptive selection of global and local search operations is, at least, feasible as it performs only second-best to a discrete variant of PSO, called DPSO. Concerning obtaining the best mean test suite size, the fuzzy adaptation even outperforms DPSO occasionally. We discuss the reasons behind this performance and outline relevant areas of future work.Comment: 21 page

Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.

We developed a systematic approach to map human genetic networks by combinatorial CRISPR-Cas9 perturbations coupled to robust analysis of growth kinetics. We targeted all pairs of 73 cancer genes with dual guide RNAs in three cell lines, comprising 141,912 tests of interaction. Numerous therapeutically relevant interactions were identified, and these patterns replicated with combinatorial drugs at 75% precision. From these results, we anticipate that cellular context will be critical to synthetic-lethal therapies

Planar Drawings of Fixed-Mobile Bigraphs

A fixed-mobile bigraph G is a bipartite graph such that the vertices of one partition set are given with fixed positions in the plane and the mobile vertices of the other part, together with the edges, must be added to the drawing. We assume that G is planar and study the problem of finding, for a given k >= 0, a planar poly-line drawing of G with at most k bends per edge. In the most general case, we show NP-hardness. For k=0 and under additional constraints on the positions of the fixed or mobile vertices, we either prove that the problem is polynomial-time solvable or prove that it belongs to NP. Finally, we present a polynomial-time testing algorithm for a certain type of "layered" 1-bend drawings