A blind deconvolution approach to recover effective connectivity brain networks from resting state fMRI data

A great improvement to the insight on brain function that we can get from fMRI data can come from effective connectivity analysis, in which the flow of information between even remote brain regions is inferred by the parameters of a predictive dynamical model. As opposed to biologically inspired models, some techniques as Granger causality (GC) are purely data-driven and rely on statistical prediction and temporal precedence. While powerful and widely applicable, this approach could suffer from two main limitations when applied to BOLD fMRI data: confounding effect of hemodynamic response function (HRF) and conditioning to a large number of variables in presence of short time series. For task-related fMRI, neural population dynamics can be captured by modeling signal dynamics with explicit exogenous inputs; for resting-state fMRI on the other hand, the absence of explicit inputs makes this task more difficult, unless relying on some specific prior physiological hypothesis. In order to overcome these issues and to allow a more general approach, here we present a simple and novel blind-deconvolution technique for BOLD-fMRI signal. Coming to the second limitation, a fully multivariate conditioning with short and noisy data leads to computational problems due to overfitting. Furthermore, conceptual issues arise in presence of redundancy. We thus apply partial conditioning to a limited subset of variables in the framework of information theory, as recently proposed. Mixing these two improvements we compare the differences between BOLD and deconvolved BOLD level effective networks and draw some conclusions

Discrete scale invariance and complex dimensions

We discuss the concept of discrete scale invariance and how it leads to complex critical exponents (or dimensions), i.e. to the log-periodic corrections to scaling. After their initial suggestion as formal solutions of renormalization group equations in the seventies, complex exponents have been studied in the eighties in relation to various problems of physics embedded in hierarchical systems. Only recently has it been realized that discrete scale invariance and its associated complex exponents may appear ``spontaneously'' in euclidean systems, i.e. without the need for a pre-existing hierarchy. Examples are diffusion-limited-aggregation clusters, rupture in heterogeneous systems, earthquakes, animals (a generalization of percolation) among many other systems. We review the known mechanisms for the spontaneous generation of discrete scale invariance and provide an extensive list of situations where complex exponents have been found. This is done in order to provide a basis for a better fundamental understanding of discrete scale invariance. The main motivation to study discrete scale invariance and its signatures is that it provides new insights in the underlying mechanisms of scale invariance. It may also be very interesting for prediction purposes.Comment: significantly extended version (Oct. 27, 1998) with new examples in several domains of the review paper with the same title published in Physics Reports 297, 239-270 (1998

CMOS design of chaotic oscillators using state variables: a monolithic Chua's circuit

This paper presents design considerations for monolithic implementation of piecewise-linear (PWL) dynamic systems in CMOS technology. Starting from a review of available CMOS circuit primitives and their respective merits and drawbacks, the paper proposes a synthesis approach for PWL dynamic systems, based on state-variable methods, and identifies the associated analog operators. The GmC approach, combining quasi-linear VCCS's, PWL VCCS's, and capacitors is then explored regarding the implementation of these operators. CMOS basic building blocks for the realization of the quasi-linear VCCS's and PWL VCCS's are presented and applied to design a Chua's circuit IC. The influence of GmC parasitics on the performance of dynamic PWL systems is illustrated through this example. Measured chaotic attractors from a Chua's circuit prototype are given. The prototype has been fabricated in a 2.4- mu m double-poly n-well CMOS technology, and occupies 0.35 mm/sup 2/, with a power consumption of 1.6 mW for a +or-2.5-V symmetric supply. Measurements show bifurcation toward a double-scroll Chua's attractor by changing a bias current

Historical forest biomass dynamics modelled with Landsat spectral trajectories

Acknowledgements National Forest Inventory data are available online, provided by Ministerio de Agricultura, Alimentación y Medio Ambiente (España). Landsat images are available online, provided by the USGS.Peer reviewedPostprin