50,997 research outputs found
The Hopfield model and its role in the development of synthetic biology
Neural network models make extensive use of
concepts coming from physics and engineering. How do scientists
justify the use of these concepts in the representation of
biological systems? How is evidence for or against the use of
these concepts produced in the application and manipulation
of the models? It will be shown in this article that neural
network models are evaluated differently depending on the
scientific context and its modeling practice. In the case of
the Hopfield model, the different modeling practices related to
theoretical physics and neurobiology played a central role for
how the model was received and used in the different scientific
communities. In theoretical physics, where the Hopfield model
has its roots, mathematical modeling is much more common and
established than in neurobiology which is strongly experiment
driven. These differences in modeling practice contributed to
the development of the new field of synthetic biology which
introduced a third type of model which combines mathematical
modeling and experimenting on biological systems and by doing
so mediates between the different modeling practices
Computational physics of the mind
In the XIX century and earlier such physicists as Newton, Mayer, Hooke, Helmholtz and Mach were actively engaged in the research on psychophysics, trying to relate psychological sensations to intensities of physical stimuli. Computational physics allows to simulate complex neural processes giving a chance to answer not only the original psychophysical questions but also to create models of mind. In this paper several approaches relevant to modeling of mind are outlined. Since direct modeling of the brain functions is rather limited due to the complexity of such models a number of approximations is introduced. The path from the brain, or computational neurosciences, to the mind, or cognitive sciences, is sketched, with emphasis on higher cognitive functions such as memory and consciousness. No fundamental problems in understanding of the mind seem to arise. From computational point of view realistic models require massively parallel architectures
SIRENA: A CAD environment for behavioural modelling and simulation of VLSI cellular neural network chips
This paper presents SIRENA, a CAD environment for the simulation and modelling of mixed-signal VLSI parallel processing chips based on cellular neural networks. SIRENA includes capabilities for: (a) the description of nominal and non-ideal operation of CNN analogue circuitry at the behavioural level; (b) performing realistic simulations of the transient evolution of physical CNNs including deviations due to second-order effects of the hardware; and, (c) evaluating sensitivity figures, and realize noise and Monte Carlo simulations in the time domain. These capabilities portray SIRENA as better suited for CNN chip development than algorithmic simulation packages (such as OpenSimulator, Sesame) or conventional neural networks simulators (RCS, GENESIS, SFINX), which are not oriented to the evaluation of hardware non-idealities. As compared to conventional electrical simulators (such as HSPICE or ELDO-FAS), SIRENA provides easier modelling of the hardware parasitics, a significant reduction in computation time, and similar accuracy levels. Consequently, iteration during the design procedure becomes possible, supporting decision making regarding design strategies and dimensioning. SIRENA has been developed using object-oriented programming techniques in C, and currently runs under the UNIX operating system and X-Windows framework. It employs a dedicated high-level hardware description language: DECEL, fitted to the description of non-idealities arising in CNN hardware. This language has been developed aiming generality, in the sense of making no restrictions on the network models that can be implemented. SIRENA is highly modular and composed of independent tools. This simplifies future expansions and improvements.Comisión Interministerial de Ciencia y Tecnología TIC96-1392-C02-0
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