9,569 research outputs found
De Novo Assembly of Nucleotide Sequences in a Compressed Feature Space
Sequencing technologies allow for an in-depth analysis
of biological species but the size of the generated datasets
introduce a number of analytical challenges. Recently, we
demonstrated the application of numerical sequence representations
and data transformations for the alignment of short
reads to a reference genome. Here, we expand out approach
for de novo assembly of short reads. Our results demonstrate
that highly compressed data can encapsulate the signal suffi-
ciently to accurately assemble reads to big contigs or complete
genomes
Performance and scalability of indexed subgraph query processing methods
Graph data management systems have become very popular
as graphs are the natural data model for many applications.
One of the main problems addressed by these systems is subgraph
query processing; i.e., given a query graph, return all
graphs that contain the query. The naive method for processing
such queries is to perform a subgraph isomorphism
test against each graph in the dataset. This obviously does
not scale, as subgraph isomorphism is NP-Complete. Thus,
many indexing methods have been proposed to reduce the
number of candidate graphs that have to underpass the subgraph
isomorphism test. In this paper, we identify a set of
key factors-parameters, that influence the performance of
related methods: namely, the number of nodes per graph,
the graph density, the number of distinct labels, the number
of graphs in the dataset, and the query graph size. We then
conduct comprehensive and systematic experiments that analyze
the sensitivity of the various methods on the values of
the key parameters. Our aims are twofold: first to derive
conclusions about the algorithms’ relative performance, and,
second, to stress-test all algorithms, deriving insights as to
their scalability, and highlight how both performance and
scalability depend on the above factors. We choose six wellestablished
indexing methods, namely Grapes, CT-Index,
GraphGrepSX, gIndex, Tree+∆, and gCode, as representative
approaches of the overall design space, including the
most recent and best performing methods. We report on
their index construction time and index size, and on query
processing performance in terms of time and false positive
ratio. We employ both real and synthetic datasets. Specifi-
cally, four real datasets of different characteristics are used:
AIDS, PDBS, PCM, and PPI. In addition, we generate a
large number of synthetic graph datasets, empowering us to
systematically study the algorithms’ performance and scalability
versus the aforementioned key parameters
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